Proteolysis-targeting chimeras as a novel strategy for targeting epigenetic mechanisms in Plasmodium falciparum parasites

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Genetically diverse Plasmodium falciparum Southern Africa isolates provides insights into antimalarial drug sensitivity and gametocyte biology

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Repositioning the antitubercular candidate SQ109 as potent antimalarial with polypharmacology

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In vitro validation of chemo-transcriptomic fingerprints for the classification of the mode of action of antimalarial drugs

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Evaluation of the in vitro antiplasmodial and toxicity profiles of novel drug delivery formulations for combination therapies

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Unravelling the role of Aurora kinases in cell cycle regulation of malaria parasites

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Mass spectrometry-based proteomics to delineate the complete histone code in both asexual and gametocyte stages of Plasmodium falciparum

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Radiolabelled antibodies as a detection tool for malaria parasite (Plasmodium falciparum 3D7)- infected human erythrocytes

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Deconvoluting drug mode-of-action : transcriptomic evaluation of novel clinical lead antimalarials

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Biochemical characterisation of putrescine and spermidine uptake as a potential therapeutic target against the human malaria parasite, Plasmodium falciparum

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Biochemical and structural characterization of novel drug targets regulating polyamine biosynthesis in the human malaria parasite, Plasmodium falciparum

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Structure-based drug discovery against a novel antimalarial drug target, S-adenosylmethionine decarboxylase/ornithine decarboxylase

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Metabolomic analyses of the malaria parasite after inhibition of polyamine biosynthesis

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Transcriptional and post-transcriptional gene regulatory mechanisms in the malaria parasite, Plasmodium falciparum

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Transcriptome- and proteome-wide responses to putrescine depletion in the human malaria parasite, Plasmodium falciparum

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The effect of herbicides as novel antimalarial drugs on the transcriptome and proteome of Plasmodium falciparum

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Targeted inhibition of the Plasmodium falciparum Vitamin B6 producing enzyme Pdx1 and the biochemical and functional consequences thereof

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High-content and super-resolution microscopy reveals the dynamic nuclear architecture and mobile epigenetic marks in Plasmodium falciparum

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Targeted inhibition of the Plasmodium falciparum Vitamin B6 producing enzyme Pdx1 and the biochemical and functional consequences thereof

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In vitro antiplasmodial activity of an optimised series of alkylated (bis)urea and (bis)thiourea polyamine analogs

Other Authors: “…Birkholtz, Lyn-Marie…”
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