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Design and synthesis of potential inhibitors of enzymes involved in the biosynthesis and utilisation of mycothiol
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Synthesis of side-chain-modified mycothiol analogues incorporating carbazole quinones, and evaluation as inhibitors of enzymes in the Mycobacteria
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New synthetic routes to functionalized 2-C-alkylglucosides, precursors of potential inhibitors of mycothiol biosynthesis in the Mycobacteria
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Engineering and application of glycosidase derived biocatalysts in the study of mycothiol pathway enzymes
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Development of a drug discovery protocol through the expression of key mycothiol biosynthetic enzymes for Mycobacterium tuberculosis
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Inhibition of a Mycothiol biosynthetic enzyme and a detoxification enzyme as anti-tubercular drug targets
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Mycothiol disulfide reductase as a drug target
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Biocatalytic preparation and characterization of alternative substrate of MshB, a mycothiol pathway enzyme
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Helical reconstruction of Mycobacterium smegmatis Mycothiol S-conjugate amidase filaments
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Attempted routes towards the synthesis of fluorinated analogues of ornithine as potential inhibitors of ornithine decarboxylase
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The synthesis of analogues and bioisosteres of the acetylcholinesterase inhibitor donepezil in an attempt to identify novel anti-Alzheimer’s agents
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Strategies towards the synthesis of prostaglandin analogues
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Design and synthesis of rotational analogues of estradiol
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Substrate binding to MshB, a zinc-dependent deacetylase in the mycothiol biosynthetic pathway of Mycobacterium tuberculosis
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Synthesis of delta-1(9)-octalinols and their analogues
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Antibiofilm activity of South African plant extracts against Mycobacterium spp. and their mechanism of action using Mycothiol reductase
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Stereoselective synthesis 2-C-alkylglucosides, potential inhibitors of mycobacterial MshB and related enzymes
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Synthesis and structure-activity studies of skeletally modified estradiol analogues
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Synthesis and evaluation of D-cycloserine analogues against mycobacterium tuberculosis
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Small molecule inhibitors of parasitic enzymes
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Design, synthesis and biological evaluation of verapamil analogues, reversed isoniazids and hybrid efflux pump inhibitors against Mycobacterium tuberculosis
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Antiplasmodial neolignans from Trema orientalis : identification, synthesis and analogue generation.
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Synthesis of novel staurosporine analogues as potential kinase inhibitors
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Development of new methodologies for functionalizing glycals and 1,2-cyclopropanated sugars, and applications in the synthesis of inhibitors of enzymes in the Mycobacteria
