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Author: Avgenikos, Moscos

  • Author: Gould, Khaya TImothy
  • Author: Hodson, Luke
  • Author: Janse van Rensburg, Mari
  • Author: Mabank, Tanya
  • Author: Steyn, Kim
  • Author: Van der Westhuizen, Leandi
  • Author: Van der Westhuyzen, Alet E.
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    Synthesis of small molecule bioactive compounds with potential anti–cancer activity

Author: Botes, Marthinus Gerhardus

  • Author: Gould, Khaya TImothy
  • Author: Hodson, Luke
  • Author: Janse van Rensburg, Mari
  • Author: Mabank, Tanya
  • Author: Steyn, Kim
  • Author: Van der Westhuizen, Leandi
  • Author: Van der Westhuyzen, Alet E.
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    Towards the synthesis of makaluvamine-analogues

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    Crosstalk between the androgen and estrogen receptors in breast cancer
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    Investigating progestin-mediated crosstalk between the androgen receptor and estrogen receptor subtypes in breast cancer cell lines
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    The role of estrogen receptors in anxiety disorders: an investigation in zebrafish
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    Investigating progesterone and estrogen receptor crosstalk in breast cancer
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    Combinatorial treatments of tamoxifen with SM6Met, a selective estrogen receptor subtype modulator (SERSM), from Cyclopia subternata are superior to current endocrine treatments in breast cancer cell models.
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    Investigating the influence of the progesterone receptor isoforms on androgen receptor activity in breast and prostate cancer cell lines
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    Phytoestrogenic extracts of Cyclopia modulate molecular targets involved in the prevention and treatment of breast cancer
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    In vitro modulation of androgen and estrogen receptors in human prostate cells by essential fatty acids
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    An investigation into the biosynthesis, metabolism and activity of 11-oxygenated estrogens
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    Hormone-receptor expression status of epithelial ovarian cancer in Ibadan, South-western Nigeria
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    Hormone–receptor expression status of epithelial ovarian cancer in Ibadan, South-western Nigeria
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    Hormone–receptor expression status of epithelial ovarian cancer in Ibadan, South-Western Nigeria
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    Isolation and identification of compounds conferring phytoestrogenic activity to Cyclopia extracts
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    An operational model for estrogenic action in the presence of sex hormone binding globulin (SHBG)
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    The role of estrogen receptors in fibrosis: in search of therapeutics
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    Crosstalk between the androgen receptor and progesterone receptor isoforms in breast and prostate cancer
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    Hormonal receptor expression in endometrial carcinoma: a retrospective immunohistochemical study in a Nigerian tertiary hospital
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    Hormonal Receptor Expression in Endometrial Carcinoma: A Retrospective Immunohistochemical Study in a Nigerian Tertiary Hospital
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    Strategies for the detection of endocrine disrupting compounds utilising recombinant oestrogen receptor ligand-binding domains and high specificity monoclonal antibodies
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    Investigating the mechanism of action of hormones used in hormone replacement therapy via estrogen receptor subtypes and the influence of the progesterone receptor
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    Chemotherapy naive breast cancer: a correlation study between BD Cytorich™ Red cell blocks and formalin- fixed paraffinembedded tissue blocks
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    Melatonin incorporation into hormone replacement therapy: a potential strategy to decrease breast cancer risk?
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    The paracrine effects of fibroblasts on Doxorubicin-treated breast cancer cells
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    Characterization of candidate genes related to estrogenic activity in Oreochromis mossambicus

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    Design and synthesis of Covalent Kinase Inhibitors Utilising Novel Electrophiles
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    Design, synthesis and biological activity studies of 1-aryl-3-(4-methoxybenzyl)ureas as proposed irreversible GSK-3 inhibitors in Alzheimer’s disease therapeutic development
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    The synthesis of novel kinase inhibitors using click chemistry
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    Synthesis of novel staurosporine analogues as potential kinase inhibitors
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    Expanding the scope of bacterial pantothenate kinase inhibitors for application in antibacterial drug development
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    Engineering reaction chemistry with flow technology : a discussion on method development and multi-step organic synthesis
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    Investigating the effects of progestins and adiposity on c-Jun N terminal kinase (JNK) signalling in breast cancer
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    Synthesis of polymer-bound small-molecule kinase inhibitors as anti-tumour agents
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    Machine learning approaches towards identifying inhibitors for plasmodium falciparum cGMP-dependent protein kinase.
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    Design and synthesis of dual-heterocyclic hybrid inhibitors for malaria and cancer
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    Investigation and characterisation of dephospho-coenzyme A kinase: a potential drug target
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    4-Aza-Podophyllotoxins: synthesis and use as anti-cancer agents
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    The rational design and synthesis of novel HIV non-nucleoside reverse transcriptase inhibitors
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    Synthesis and optical resolution of 4,5-diaminohomoadamantane: a promising scaffold for chiral ligands and bioactive compounds
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    Nanostructured scaffold for neural tissue regeneration
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    An efficient heterogeneous catalyst (CuO@ARF) for on-water C-S coupling reaction: an application to the synthesis of phenothiazine structural scaffold
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    Erratum to: Design and synthesis of tetrahydrophthalimide derivatives as inhibitors of HIV-1 reverse transcriptase
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    Erratum to: Design and synthesis of tetrahydrophthalimide derivatives as inhibitors of HIV-1 reverse transcriptase
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    Design and synthesis of benzazole ureas as proposed irreversible GSK-3β inhibitors
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    The effect of MKP-1 inhibition on the cytotoxicity of chemotherapeutic drugs in breast cancer
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    Characterization of prokaryotic pantothenate kinase enzymes and the development of type-specific inhibitors
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    In vitro effect of a sirtuin inhibitor and its possible synergistic effect with a potential tubulin inhibitor on breast cancer cell lines
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    Design and development of novel irreversible GSK-3β inhibitors to address Alzheimer's disease
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    In-silico guided design, synthesis and bio-evaluation of potential chemotherapeutic agents against malaria, cancer and disease-causing pathogens

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