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Spermatozoal, seminal plasma and blood sperm antibodies in Nigerian males
Published 2001Subjects: “…Male infertility…”
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Spermatozoal, seminal plasma and blood sperm antibodies in Nigerian males
Published 2001Subjects: “…Male infertility…”
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Page will reload when a filter is selected or excluded.- Infertility 8 results 8
- Male infertility 5 results 5
- Sexually transmitted diseases 5 results 5
- Blood 2 results 2
- Chlamydia trachomatis 2 results 2
- Hormones 2 results 2
- Infertility is common in Nigeria and the male role is now well recognized. Sperm antibodies (SA) have been observed as a cause of infertility and their production have in some circumstances been attributed to chronic infection of the genital tract. Sexually transmitted diseases (STDs) and infection-related infertility are reportedly highly prevalent in Nigeria. This study was therefore designed to evaluate the role of sperm antibodies and determine the involvement of STDs in the production of such SA among Nigerians. 122 adult males aged 18-56 years were investigated. 25 were normospermic, fertile males with no evidence of STDs and served as controls. 50 were infertile without STDs while 47 had proven STDs Immunobead binding technique was used for the detection of SA directly on the sperm cell, in seminal and blood plasma. Student’s t-test and anova (one-way) were used for statistical analysis of data obtained. Results showed that SA- IgG, IgA and IgM were present in blood and semen. However, mean percentage binding of these SA on motile sperm was low (<4%). Comparisons of SA in blood and semen between infertile/STDs groups and. fertile controls were not significantly different (p>0.05) The findings suggest that sperm antibodies are present but may not be associated with STDs or infertility in Nigeria males. 2 results 2
- Oxidative stress 2 results 2
- Seminal plasma 2 results 2
- Sperm antibodies 2 results 2
- Spermatozoa 2 results 2
- Tubal obstruction 2 results 2
- Zinc 2 results 2
- "Infertility 1 results 1
- A 30 year-old P0+1 lady who was referred to the gynaecology clinic on account of inability to conceive for 8 years duration and progressive abdominal distension of 2 years duration. She had a history of severe cyclical dysmenorrhoea warranting occasional hospitalization. An abdomino-pelvic ultrasound revealed marked intra-abdominal collection. The uterus and ovaries appeared normal. She subsequently had laparoscopy and drainage of 6 litres of endometriotic ascites. Both fallopian tubes were diseased. She was followed up on an out-patient basis with sub-cutaneous goserelin injections and referred for assisted reproduction. 1 results 1
- Acceptability 1 results 1
- Anxiety 1 results 1
- Artificial Insemination by Donor (AID) 1 results 1
- Ascites 1 results 1
- Assisted Reproductive Technology 1 results 1
- Assisted reproductive technology 1 results 1
- Baby Factory 1 results 1
- Background and Objectiver Infertility is a socially destabilising health problem, which remains a cause of stigma and threat to couples desirous of conception in Nigeria. This sludy aimed to ecxamine the pattern of presentation and management outcome of infertility at LAUTECH Teaching Hospital (LTH), Ogbomoso. Methods A descriptive retrospective study of infertile couples attending the gynaecological clinicovera 3-yearpe-riod was conducted. Intonation on sociodemographic and gynaccological characteristics, medical history and management outcome was obtained from the medical reconls of the patients using a stctured proforma Data was analysed using SPSS version 20.0. Results The incidence of infertility was 34.30ol The mean age of the infertile women was 6.44 4.7 ycars. Secondary infertility/ accounted for the majority of the cases (73.0") with the_ mean duration of infertility being3,92 1 years. Male factor was identified in 10.4 of cases while female factor wasscen in 4L6"ot cases Both partners contributed to infertility in 34% while there was no identifiable cause in 14%. The commonest causes of infertility in the women were inadequate coital exposure, previous abnormal vaginal discharge and previous induced abortion representing 39.5%, 37.1%, and 33.7% respectively. Pregnancy was achieved in 3.0% of the women following treatment Conclusion The institutional incidence of infertility was high with a preponderance of secondary infertility. Pregnancy rate following conventional treatment was poor 1 results 1
- Background: Artificial insemination by donor (AID) is specifically indicated in cases of incurable male infertility. Acceptability depends on perceptions largely influenced by religious and sociocultural perspectives. Male factor accounts for 20-50% of the causes of infertility and shows geographic variation in Nigeria. Method: A descriptive cross-sectional survey of all infertile women attending the gynecology clinic of the University College Hospital, Ibadan, between January and June 2014. 181 self-administered questionnaires were distributed to all consenting infertile women, however only 163 were suitable for analysis. Data analysis was descriptive and inferential at 95% confidence interval and a P value of less than 0.05 was considered statistically significant. Result: The mean duration of infertility was 5.7 ± 4.33 years. Fifty seven (35.0%) respondents were willing to accept artificial insemination by donor, while ninety three (57.1%) were unwilling to accept artificial insemination. Socio-cultural factor (48.1%) was the major reason for non-acceptability of artificial insemination by donor. Acceptability of AID was influenced by adequate knowledge about the procedure (P < 0.01). Sixty percent of the respondents had good knowledge and over half of them obtained the information from the news/print media. In this Study, acceptability of AID was not influenced by the age of the respondents, family structure, duration or type of infertility or educational status. (P > 0.05). Conclusion: This study revealed a low acceptance rate for Artificial insemination by donor. Providing information on AID as a treatment option during counseling and routine infertility management may be the needed drive to improve awareness and promote uptake when necessary. 1 results 1
- Background: Chlamydia trachomatis (C. trachomatis), is the most common bacterial Sexually Transmitted Infection, a major cause of Pelvic Inflammatory Disease and female infertility. Since C. trachomatis infections are frequently asymptomatic with higher prevalence in developing countries, highly sensitive and affordable methods are desirable for routine screening and diagnosis. This study aimed to evaluate the performance of C. trachomatis-specific IgG antibody by ELISA as a screening tool for C. trachomatis infection, by comparing the performance of ELISA with the gold standard Polymerase Chain Reaction( PCR). Method: In this cross sectional study, we enrolled 150 women attending infertility clinic at Ibadan between January and November, 2015. ELISA for detection of IgG antibodies specific to C. trachomatis major outer membrane protein (MOMP) was performed on the blood samples using third generation indirect Enzyme Linked Immunosorbent Assay (ELISA) and endocervical samples were analyzed for presence of C. trachomatis nucleic acid using PCR. Socio demographic bio-data and gynaecological history were obtained with questionnaire; data was analyzed using SPSS version 20.0. Results: Overall, 58 (38.7%) were positive for C. trachomatis specific IgG antibody by ELISA and 11 (7.3%) for C. trachomatis nucleic acid by PCR. Using PCR as the gold standard, ELISA had a sensitivity of 81.8% specificity of 64.8%, positive predictive value of 15.5% negative predictive value of 97.8% and accuracy of 66%. Conclusion: The high sensitivity of the ELISA indicates that over 80% of patients identified as being positive in the screened population are truly infected. Also, the negative predictive value approaches 100% amongst those screened out as being negative. Thus its use as a screening tool for C. trachomatis infection is warranted particularly in developing countries where cheaper and easier to use alternatives to PCR are in dire need. 1 results 1
- Background: Genital Chlamydia infection (GCI) and the associated pathologies have been implicated in tubal infertility. Though the actual pathologic mechanisms are still uncertain, oxidative stress and other factors have been implicated. The purpose of the study was to determine the possible contribution of female reproductive hormones and biomarkers of oxidative stress in genital Chlamydial infection to tubal occlusion. Methods: This prospective case control study was carried out by recruiting 150 age matched women grouped into infertile Chlamydia positive women (n=50), fertile Chlamydia positive women (n=50) and fertile Chlamydia negative women as controls (n=50). High vaginal swabs and endocervical swabs were collected for screening Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis, Treponema pallidum, Staphylococcus aureus, and Candida albicans. Sera were collected for estimation of Chlamydia trachomatis antibody, female reproductive hormones [Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH), Oestradiol (E2), Progesterone (P4), Prolactin (PRL)] and biomarkers of oxidative stress [Total Antioxidant Capacity (TAC) and 8-hydroxyl-2-deoxyguanosine (8-OHdG)] by enzyme immunoassay (EIA). Data were analyzed using chi square, analysis of variance and LSD Post hoc to determine mean differences at p=0.05. Results: Among women with GCI, higher levels of LH and 8-OHdG were observed in infertile Chlamydia positive women compared to fertile Chlamydia positive women (p<0.05). Higher levels of LH and 8-OHdG and lower TAC levels were observed in infertile Chlamydia positive women compared to fertile Chlamydia negative controls (p<0.05). Conclusion: Mechanisms including oxidative DNA damage and reduced antioxidant capacity may be involved in the pathology of Chlamydia induced tubal damage. 1 results 1
- Background: Genital tract infections and obesity are both sources of oxidative stress. Alterations in immune and antioxidant parameters may arise from this or from an indeterminate autoimmune mechanism. Objective: This study aimed to investigate the association of Chlamydial infection, obesity and oxidative response with tubal infertility in Nigerian women. Methods: It was a case-control study of 40 women with tubal infertility and 32 fertile women, respectively, recruited from the Infertility and Family Planning Clinics respectively, of the University College Hospital, Ibadan, Nigeria. Anthropometric indices were measured in each subject and endocervical swabs were taken to screen for current genital tract infection. Antioxidant, hormonal and immunologic analysis were performed on serum. Results: None of the subjects had current genital tract infections. Chlamydia trachomatis IgG positivity was significantly higher in infertile than in fertile subjects [OR 4.33; 95%CI (0.078-0.681)]. No significant variations were observed in the anthropometric indices, antioxidant parameters and hormones between infertile and the fertile women. Body mass index correlated positively with oxidative stress in infertile subjects. Waist and hip circumferences correlated negatively with oestradiol in women with tubal infertility. Conclusion: Chlamydial infection is associated with tubal factor infertility, however, obesity seems to increase oxidative stress and reduce fertility potential in women with tubal factor infertility. 1 results 1
- Background: Immune response to genital Chlamydia trachomatis infection is involved in both immunity and pathology. The cytokine profile during infection has been implicated in the disease outcome, either resolution or severe sequelae. Serum cytokines of Chlamydia positive Nigerian women with tubal infertility were assessed to determine their possible relationship with tubal occlusion. Material and methods: One hundred and fifty age-matched consenting women (100 fertile and 50 with tubal infertility) were recruited based on C. trachomatis antibody positivity and grouped into infertile Chlamydia positive (CTpos) women (n = 50), fertile Chlamydia positive women (n = 50) and fertile Chlamydia negative (CTneg) women as controls (n = 50). High vaginal swabs and endo-cervical swabs were collected for microscopy, culture and gram staining. Cytokines [transforming growth factor β1 (TG F-β1), interferon γ (IFN-γ), tumor necrosis factor α (TNF-α), interleukin (IL )-4, IL -10 and IL-17A] were estimated by ELISA in sera. Data were analyzed using ANOVA, χ2 and Spearman’s correlation at p = 0.05. Results: Lower IFN-γ levels were observed in infertile women compared to fertile women. Fertile CTneg women had significantly higher TNF-α, and TGF-β1 compared to fertile and infertile CTpos women, respectively. Lower IL-10 levels were seen in fertile CTpos women compared to the infertile CTpos group. Vaginal discharge was negatively correlated with TNF-α and IFN-γ and positively with IL-4 in Chlamydia positive women. Conclusions: Chlamydia positive women with tubal infertility have higher IL -10 and lower IFN-γ levels than controls, which may contribute to their development of tubal pathology. 1 results 1
- Background: Infertility is a global public health issue affecting couples. Trace metals have been implicated in effective reproductive functions in males but less studied in females. Objective: To compare the serum levels of copper (Cu), zinc (Zn), selenium (Se) and copper/zinc ratio in women with unexplained infertility and fertile women. Subjects and Methods: This was a cross-sectional analytical study that compared 75 consenting women who had unexplained infertility with 74 fertile women that were controls. Both groups were seen within 1 year of delivery and were recruited from the family planning unit, at the University College Hospital, Ibadan. Data were obtained through a semi-structured questionnaire, after which 10 mL of venous blood was collected. Analysis of selected trace elements were done by atomic absorption spectrophotometry. IBM SPSS version 23 was utilized for data analysis and the levels of statistical significance was set at <0.05. Results: The mean (±SD) serum concentrations of Cu (93.11 ± 16.55 μg/dL), Zn (72.04 ± 15.03 μg/dL) and Se (28.28±8.33 μg/dL) amongst the women with unexplained infertility were lower when compared to the control group (all with P<0.001). The serum Cu/Zn ratio was higher among the fertile women, though not statistically significant (P<0.62). Age of <35 years was associated with normal serum levels of Cu (P<0.01), while women with normal body mass index had low serum concentrations of Cu (P=0.04), amongst the fertile group. Conclusion: Serum copper, zinc and selenium concentrations are significantly lower in women with unexplained infertility, therefore diets or supplements containing these trace elements may be helpful in their management. 1 results 1
- Background: Psychological consequences of infertility have been documented in both developed and less developed countries. Depression and anxiety disorders have been identified as important causative factors. The prevalence of psychiatric morbidity amongst infertile women has been shown to be quite high with values as high as 46.4%. A high premium is placed on childbirth in Nigeria and failure to conceive is associated with disastrous consequences. Failed In-Vitro Fertilization (IVF) cycles have been implicated in psychological distress. Objective: This study aimed to determine the prevalence of anxiety and depression amongst infertile women undergoing IVF and to examine the psychosocial stressors associated with the development of these morbidities. Materials and Methods: A descriptive cross sectional study of fifty-one infertile women attending an In-Vitro Fertilization clinic in Lagos, South Western, Nigeria. Participants were recruited consecutively at their first consultation visit and a self-administered questionnaire consisting of sociodemographic information along with the Hospital Anxiety and Depression Scale (HADS) was completed by the participants. Data obtained from the respondents was analyzed using the Statistical Package for Social Sciences (IBM SPSS, New York) version 21. The Chi-Square statistic was used in testing for associations between categorical variables. Results: The mean age of the respondents was 38.96 ± 5.91 years with a range of 23-49 years. 76.5% (39/51) of the women had infertility greater than 5 years, while 49 % (25/51) of the women were aged 40 years and above with 96% (24/25) of this group experiencing infertility greater than 5 years. Anxiety was recorded in 24 respondents (47.1%) while Eighteen respondents (35.3%) had evidence of depression. Marital disharmony was found to be associated with the development of anxiety (P<0.05) Conclusion: The impact of infertility on the Nigerian couple can be devastating. Lack of support coupled with the overbearing and intrusive nature of family members predisposes to the development of psychosocial distress. We therefore recommend that Physicians pay attention to the psychosocial stressors experienced by infertile women prior to In Vitro Fertilization with the aim of ensuring appropriate referral for psychiatric assessment and treatment. 1 results 1
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