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Serum protein binding and the antimicrobial activities of garcinia kola, kola acuminata and kola nitida seed extracts on the agents of respiratory tract infections
Published 2009Subjects: “…Serum proteins…”
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Page will reload when a filter is selected or excluded.- Protein 4 results 4
- Protein quality 3 results 3
- Quality protein maize 3 results 3
- Acute phase proteins 2 results 2
- Biodiversity conservation 2 results 2
- Biotechnology 2 results 2
- Brain 2 results 2
- Cholinergic System 2 results 2
- Clarias gariepinus 2 results 2
- Cobalt (Co) toxicity has been reported to produce central nervous system and gastrointestinal abnormalities. This study assessed the therapeutic effect of cholecalciferol (Cho) supplementation against damages caused by sub-acute (14-day) cobalt chloride (CoCl2) exposure in the brain and intestines. Thirty-five male Wistar rats were divided equally into five groups: Group I (control) received no treatment; Group II received oral CoCl2 (100 mg/kg) only; Groups III, IV, and V received 1000, 3000 and 6000 IU/kg of cholecalciferol, respectively by oral gavage, and concurrently with CoCl2. Cobalt-treated rats showed neuronal vacuolation and presence of pyknotic nuclei in the cerebral cortex and hippocampus, depletion of Purkinje cells in the cerebellum, as well as inflammation and congestion in the intestinal mucosa. Cobalt also increased brain and intestinal hydrogen peroxide (H2O2) and malondialdehyde (MDA) concentrations, while simultaneously reducing glutathione (GSH) content, superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione S-transferase (GST) activities. Further, CoCl2 induced increases in brain acetylcholinesterase (AchE) activity and serum zonulin (ZO-1) levels. Conversely, Cho administration suppressed CoCl2-induced damages in the brain and intestines by reducing lipid peroxidation and increasing the activities of antioxidant enzymes. Remarkably, Cho produced stimulation of brain choline acetyltransferase (ChAT) and suppression of AchE activity, along with dose-dependent reduction in serum levels of ZO-1, intestinal fatty acid-binding protein (iFABP) and nitric oxide. In conclusion, the protective role of cholecalciferol against cobalt-induced toxicity occurred via modulation of cholinergic, intestinal permeability and antioxidant pathways. The results may prove significant in the context of the role of gut-brain connections in neuroprotection. 2 results 2
- Cobalt chloride 2 results 2
- Crude protein 2 results 2
- Crude protein digestibility 2 results 2
- Fluorescent protein 2 results 2
- Funisciurus anerythrus 2 results 2
- Grain yield 2 results 2
- Heliosciurus gambianus 2 results 2
- Heterozygosity 2 results 2
- Immunoglobulins 2 results 2
- In a bid to achieve microbial diagnostic precision and reduce diagnostic turn-around time, the development of technologically advanced,novel techniques has been on the rise. There is a gradual phasing out of traditional diagnostic methods by more specific and highly sensitive molecular techniques. Asides from being technically demanding and cost-ineffective, these molecular methods have themselves not fulfilled perhaps the most essential diagnostic criterion of distinguishing between viable and dead bacterial cells. The use of bacteriophages as biorecognition elements for bacterial detectors offers numerous advantages in terms of cost, ease of accessibility, and high specificity binding of bacteriophages to their bacterial host. Biotechnological advancements further give bacteriophage use the leading edge as genetic modification of bacteriophage genome through the fluorescent gene insertion produces reporter bacteriophages. These recombinants can produce detectable fluorescent signals through intracellular lytic action, strictly in metabolically active bacteria cells. Fluorescent labelled enzyme-active and cell wall binding domains of bacteriophages also offer better alternatives to the use of antibodies as diagnostic markers because they are resistant to pH and temperature sensitivities. Overall, bacteriophage-based detection systems are less prone to detection errors and significantly reduce diagnostic time while also attaining high test sensitivity. 2 results 2
- Intestinal Fatty Acid-Binding Protein 2 results 2
- Intestines 2 results 2
- Phage-based sensors. 2 results 2
- Polymorphism 2 results 2
- Reporter bacteriophage 2 results 2
- Soybean meal 2 results 2
- Terminalia catappa 2 results 2
- Zonulin 2 results 2
- kolaviron 2 results 2
- rats 2 results 2
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