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Beyond bottlenecks: expression of complementary enzymes and permeabilization of cell membranes to improve performance of CYP153A6 in Escherichia coli whole cell biocatalysis by White, Bronwyn Elizabeth
Published 2023“…This study has served to shed light on the links between cells, enzymes, and reactants – and on how much there still is to understand when it comes to whole cell performance.…”
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Differential proteomic profiling towards elucidation of TB-IRIS pathogenesis by Peyper, Janique Michelle
Published 2022“…Diagnosis is one of exclusion, no reliable laboratory markers exist, corticosteroid-mediated prophylaxis and therapy are only partially effective, and no treatment targets tissue damage. …”
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Page will reload when a filter is selected or excluded.- Environmental safety 2 results 2
- Female undergraduates 2 results 2
- Health 2 results 2
- Overcrowding 2 results 2
- Wellbeing 2 results 2
- "All over the world, there is an increasing enrolment level for university admissions in view of the ever-increasing benefits of earning university degrees. Thus, the high population of students in many universities, coupled with a high number of vehicles has made traffic control a challenge to University traffic managers. In this paper, the method of Resca1e Range Analysis (RRA) was used to estimate the Hurst Exponent Value (HEV) for the traffic inflow through the main entrance gate of a university as a control measure. Data from a university in the developing countries was collected and analysed. The number of vehicles that entered consecutively per five minutes was observed between 07:00 and 19:00 over a 144 count and 17 independent cases constructed between adjacent cases. Rescale Range Algorithm platform is then used for the data, and coded in FORTRAN Language. With a case made up of 128 consecutive five-minute dependent traffic inflow records, a total of 3348 vehicles entered the university community within the studied period while the average number of vehicles inflow per hour was 279. Average number of vehicles that entered per five minutes was 24. No vehicle entered between 13:25 and 13:30. For all cases, the estimated HEV range between 0.5742 and 0.6955. The computed average HEV was 0.6303, the coefficient of fitness (R2) for all cases range between 0.9552 and 0.9787, while the computed average value was 0.9680. The HEV greater than 0.5 estimated for all cases is an indication of positive con-elation called Persistent. It expresses the fact that there are extended periods in which the traffic inflow to the university community deviated from the long term mean. This information is useful for vehicle garage design. For reliable estimates of the average HEV for design purposes, the study period should be extended to a whole week or an academic session. " 1 results 1
- "Mathematics has diverse applications as decision making tool. This study investigated the use of a proposed pure mathematical formulation (i.e. excluding human factor) for citing appropriately the location of political capital ci of an inhabited designated area. Digitized data of Scale map of Nigeria as a case study was used as input to a FORTRAN 90 programme codes of an equivalent least squares method mathematical formulation. The resulting simultaneous equations involving the political capital city coordinates as unknown variables were solved using Gauss Elimination Algorithm. The political capital city Cartesian coordinate prescribed as (26, 24) in grids unit for the studied case of scale map of Nigeria compared visually satisfactorily with Abuja location on the Map. The Nigeria land area cover was under-estimated by 2.3% referencing 923,768 sq km obtained from Microsoft Encarta Premium (2009). Similarly the Nigeria coastline was estimated. as 25.3% of the country's estimated perimeter (3369 krn). This mathematical tool can be used to cite the centrally located capital city or capital city relocations economically, timely, accurately and reliably. This programme can also be used for citing of capital cities for other countries and center of any irregular shapes on two dimensional plane. " 1 results 1
- Abstract: The demand for University education in Nigeria has led to an increase in undergraduate population and this comes with various problematic conditions with regards to university accommodation, available basic infrastructure and facilities. The resultant effect is manifested in overcrowded residential halls and rooms. Against this backdrop, this study investigated the correlation between overcrowding and environmental safety and wellbeing in female undergraduate halls of residents in the University of Ibadan, Nigeria. Four research questions and two hypotheses guided the study. Descriptive survey research design was adopted and a sample of six hundred and fifty five (655) was proportionately drawn from the residential female undergraduate population of 3274. A questionnaire with reliability coefficient of 0.87 was used for data collection. The results showed that 87.7% of the female undergraduates perceived their rooms to be overcrowded. Findings on environmental safety showed that apart from fire extinguisher, other safety facilities and equipment are either not readily available or are not adequate in all the halls of residence. The result of the hypothesis showed a strong negative relationship between overpopulation and environmental safety and wellbeing. In recommendation, more halls of residents should be built to meet up with the increase in female undergraduate enrolments to Nigerian universities. Environmental safety issues of residential undergraduates must be taken seriously by providing functional safety facilities and equipment to make the halls more secure. 1 results 1
- Acoupedic Therapy 1 results 1
- Age 1 results 1
- Auditory perception 1 results 1
- Code alternation has become a common feature of oral conversation among bilinguals. However, scholars do not agree on the reasons for this. While some see it as a sign of linguistic deficiency, some see it as a welcome development and a normal feature of bilinguals. Several studies have been carried out on incidence of code alternation both locally and internationally. But very few of such studies examined reasons and implications for code alternation among Yoruba/English bilingual students. This study examines the variables that may influence bilingual —pre-service teachers in colleges of education to alternate codes in their verbal communication. Descriptive survey design was adopted in the study and all pre-service teachers at Emmanuel Alcyande College of Education, Oyo, Oyo state and Federal College of Education, Abeokuta, Ogun State constituted the population. Four hundred students were randomly selected for this study while a self constructed questionnaire titled “Code Alternation in Pre-service Teacher Communication; Reasons and Implications” which had a reliability coefficient index of 0.68 was used to elicit responses from the subjects. Chi square was used to analyse the data generated in the study. Findings revealed that participants' roles and relationship have significant influence on code alternation. Also, there is significant influence of situational factors on code alternation among the pre-service teachers in colleges of education. Based on the findings of the study, appropriate recommendations were made. 1 results 1
- Digital skills 1 results 1
- Digital technologies 1 results 1
- Earlier studies by this author in 1976 provided evidence of an association between an infective, sexually transmitted agent, the Herpes Simplex Virus Type-2 (HSV—2) and human carcinoma of the cervix, irrespective of geographic location or ethnic origin of the individuals. Similarly, HSV-2 related antigens were demonstrated by the indirect immuno-fluorescent technique in desquamated cells of carcinoma of the cervix tissues from tumour bearing patients. To highlight the Potentials of the detection of tumour antigens in tumour-faearing patients as aid to early diagnosis of the cancer, Isolation and purification of the Tumour Associated Antigens (TAA) of human cancer of the cervix were attempted by immunological and physicochemical procedures in this study. Two antigen preparations, one the Soluble Antigens (SA), and the other, the Membrane Bound Antigens (MBA) were prepared from a pool of cancer of the cervix (CaCx) tissues. The soluble antigens were extracted by homogenization in Earle’s Balanced Salt Solution (EBSS) containing antibiotics, and the membrane-bound antigens were solublised by 3-molar potassiurn Chloride (3 Molar KCl). For isolation and purification of TAA, procedures for the purification of proteins were explored. These include physicochemical stepwise ammonium sulphate fractionation, sephadex ion exchange chromatography, sephacryl S-200 gel filtration, and affinity chromatography to eliminate the normal tissue components of the antigen fractions. Hyperimmune rabbit sera were then prepared against the partially purified TAA. Immunodiffusion studies, employing hyperimmune rabbit sera prepared against the partially purified TAA were used to demonstrate tumour associated antigens in the various cancer antigen preparations, and Circulating Tumour Associated Antigens (C-TAA) in the sera of tumour- bearing patients. The TAA in the cancer tissues showed lines of identity with the C-TAA in patients sera. Techniques involving adsorption by immuno-precipitation-in-gel with Normal Cervix (NCx) tissue antigen preparations, and pooled Normal Human Sera (NHuS) were utilized for the removal of antibodies to NCx and NHuS in the rabbit sera, after which there were no reactions with NCx indicating the specificity of TAA for CaCx. A comparison of the soluble and 3 Molar KCl extracts of the cancer antigens by immuno-precipitation reaction, using adsorbed hyperimmune rabbit sera prepared against the partially purified CaCx TAA, demonstrated three TAA (TAA-1, close to the central antisera well, TAA-2, intermediate and TAA-3, close to and curving towards the peripheral antigen well) in the soluble antigen preparation. Only one TAA (probably identical to the TAA-3 of the soluble antigen) was demonstrated in the 3 Molar KCl extract. Using the rabbit antisera against the partially purified CaCx TAA, adsorbed with NCx and NHuS, results of coded sera showed that immunodiffusion reaction was able to detect circulating TAA in 75.0 per cent of patients with cancer as compared with 5.6% in women with benign gynecological diseases, 1.4% in pregnant women and 0.0% in healthy control women. The result indicates that the test has great potential for immunodiagnosis of cancer of cervix. Although the sensitivity of the test method was low, the specificity was high, and could provide a means of early diagnosis of neoplastic changes in the cervix. The detection of Circulating-TAA as tumour markers in sera of patients, may someday become routine, and thus make earlier diagnosis of cancer possible. Indications are that immuno-diagnostic procedures can be designed in ways that are reproducible, simple and reliable. Such serological tests would extend our present ability for detection and monitoring of malignancies. 1 results 1
- Economic challenges in Nigeria have prompted many undergraduate students to engage in social media entrepreneurship for financial sustainability. Platforms like Facebook and Instagram provide cost-effective business opportunities. While this entrepreneurship offers benefits, it raises concerns about its impact on academic performance, especially as students often multitask between business and studies. Grounded in the Uses and Gratifications Theory, this study investigated the relationship between social media entrepreneurship and the academic performance of undergraduates. A descriptive survey research design was employed, using a randomly selected sample of 200 students from five faculties: Education, Arts, Sciences, Law, and Social Sciences at the University of Ibadan. The instrument used for data collection was the Social Media Entrepreneurship and Academic Performance Questionnaire (SMEAPQ), which included structured items eliciting responses on the social media platforms used for entrepreneurial activities, the types of social media businesses engaged in, the influence of motivation on entrepreneurial engagement, and the impact on academic performance. The reliability of the questionnaire was established through a pilot test, yielding a coefficient of 0.75. Data were analysed using both descriptive and inferential statistics. Specifically, Pearson Product-Moment Correlation (PPMC), t-tests, and means were utilized. The findings revealed that undergraduates primarily use WhatsApp (X̄=3.59), Instagram (X̄=2.97), and Telegram (X̄=2.87) for entrepreneurial ventures, focusing on influencer marketing (X̄=3.31), web development/coding (X̄=3.24), affiliate marketing (X̄=3.19), and e-commerce (X̄=3.05). A significant positive relationship was found between undergraduate motivation and engagement in social media entrepreneurship (r=.222; p<0.05), aligning with the Uses and Gratifications Theory. Additionally, a significant positive association was observed between engagement in social media entrepreneurship and undergraduates’ academic performance (r=.236; p<0.05). The study revealed that female students had better engagement in social media businesses than male students (t(195) =-3.76; p<0.05). There is a need for targeted support to help students balance business and academics, in order to foster both financial independence and academic success. 1 results 1
- Environment 1 results 1
- Financial Independence 1 results 1
- Framing 1 results 1
- Hearing Impairment 1 results 1
- In recent time, plethora of events has shown mental health cases among undergraduates. Some of these include suicide Intention, anxiety, depression, and sleeplessness. The mental health of undergraduates calls for concern which requires an investigative consideration of personal-social factors underpinning variance in mental health status. That is, a comparative analysis of age, social media exposure and mental health: A curse or blessing. This study adopted casual comparative design. A sample of 250 undergraduate students was randomly selected from the University of Ibadan. Two reliable measuring scales (Social media exposure; a = 0.77, Mental health; a = 0.72) were used for collection. T-test, Analysis of Variance (ANOVA) used to analyse the data. The study discovered a significant difference in the mental health of undergraduates based on social media exposure (t(248)= 13.21, p<0.05, partial ɳ1 = 0.08). Participants with high social media exposure (ẋ- 48.3) had lower mental health than those with lower social media exposure (ẋ= 35.2). A significant difference in the mental health of undergraduates based on age; 44.43, p<0.05, partial ɳ2 = 0.35). It was further discovered that participants within the ages of 21 and 24 years (ẋ= 34.4) had higher mental health than those within the ages of 16 and 20 years (ẋ= 29.5). By implication, older undergraduates hove better mental health than the younger ones. Based on findings, it was recommended that university managements should adjust their policy for admission arriving at the exposure of psychological instrument that can determine the intelligent level of the candidates to know their mental age and determine eligibility for admission; in order to ascertain that the candidate is mature enough to handle academic pressure. Counselling psychology unit of the department are expected to champion this mental health screening and remediation within the university system. Also, undergraduate students are enjoined not to be committed to online friends so as to reduce negative feedbacks that come from online relationships. 1 results 1
- Mental Health 1 results 1
- Music playing function 1 results 1
- Newspapers 1 results 1
- Nigeria 1 results 1
- Nigerian association of social workers 1 results 1
- Noise 1 results 1
- Objective: The Ebola virus disease, formerly called the Ebola haemorrhagic fever, was first identified in rural Zaire (now the Democratic Republic of Congo) in 1976, where it killed 280 people. The disease had mostly been confined to relatively small outbreaks in rural settings, until the 2014 outbreak, which hit urban areas in Liberia, Sierra Leone, and Guinea. Today, the African countries affected by the outbreak of Ebola in 2014 have been able to curtail it and have even come out strong out of its devastating effect. However, this disease has a tricky way of sneaking back, as it has demonstrated in the time past. So to what extent is our stadium equipped to screen, detect, prevent and contain Ebola spread during football competitions. This has been the major focus of this research Methods: Descriptive survey research design was used for the study. It was correlational type which explores the relationships that exists among variables on which predictions are made based on the relationships. A total of 75 (Seventy five) respondents were selected from among the Sport medical personnel, coaches, athletes, sport managers/administrators and sport journalist from each stadium to make a total of 150 (one hundred and fifty) respondents. A self-developed questionnaire which has reliability coefficient of 0.87 was used to collect data while the data were analysed using inferential statistics of chi-square at 0.05 level of significance. Results: The findings of the study reveal that the selected stadia lack surveillance and detection capabilities for Ebola and other infectious diseases. It was also discovered that many personnel working in and around the stadia, athletes and spectators lack adequate knowledge about Ebola. The health facilities in around the complex too did not have functional diagnostic and containment capabilities for Ebola. Conclusions: It was concluded among others that adequate laboratory service and active surveillance capacity for Ebola detection during football competition should always be made available by the authority concern. 1 results 1
- Peer Influence 1 results 1
- Social Media Exposure 1 results 1
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- SUNScholar — Stellenbosch University Repository 109 results 109
- UPSpace — University of Pretoria Institutional Repository 89 results 89
- UCTD — University of Cape Town Open Access Repository 71 results 71
- AUC Knowledge Fountain — bepress 14 results 14
- KNUSTSpace — Kwame Nkrumah University of Science & Technology (Ghana) 4 results 4