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Investigating the relationship between plasma and intracellular concentrations of bedaquiline and its metabolite N-desmethyl bedaquiline (M2) in drug resistant-TB patients with and...
Published 2026“…This first-time investigation into intracellular bedaquiline and M2 concentrations gives insight into bedaquiline pharmacokinetics, particularly in the context of RR-TB treatment. Our method for quantifying unbound bedaquiline and M2 in human plasma provides a foundation for further research into similar highly protein-bound and lipophilic drugs.…”
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UNDERDEVELOPMENT AND COLLECTIVE SELF-RELIANCE IN THE ECONOMIC COMMUNITY OF WEST AFRICAN STATES
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The traumatic experience of divorce and its impact on women
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Liability regimes for environmental damage in South African law
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Principals’ understanding of their readiness to implement the policy on the South African Standard for Principalship
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Exploring escape rooms as a game-based learning approach to promote student motivation
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Assignment of regional and divisional managers to stores
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Eliciting pedagogical learning among teachers in a professional learning community
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Entrepreneurship and the integration of refugees and migrants: A case study of Syrian refugees in Egypt
Published 2018“…At the same time, their individual contexts are neglected due to weak and fragmented policies enforcement, dwindling living conditions, legal restrictions and social and economic limitations for their livelihoods. …”
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Reliability and validity of the South African Triage Scale in low-resource settings
Published 2018“…The SATS was designed for use in the South African context to mitigate the limited numbers of doctors and professional nurses. …”
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Health technology assessment for levetiracetam in the treatment of newly diagnosed epilepsy in the South African Public Health Sector
Published 2020“…No cost-effectiveness studies on the first-line treatment of epilepsy have been conducted in the South African context or in similar contexts using the combination of drugs in this analysis which are levetiracetam, lamotrigine, carbamazepine, phenytoin and valproate. …”
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The chromatin landscape of colorectal cancer cells
Published 2021“…Promoter-resident CBSs can also function as "docking sites” for tissue- and context-specific enhancers. The dysregulation of CTCF binding has been repeatedly demonstrated to directly alter chromatin contacts in a vast array of cellular contexts including cancer. …”
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Expectations and Preferences of Parents and Adolescents Regarding Feedback of Individual Genetic Findings in an HIV-TB Genomic Research Project in Botswana
Published 2023“…Decisions on practicalities for feedback of results should take into account participants' context and considerations of participants' preferences. …”
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A study of urban form; its analysis and its implications for sustainable settlements in desert environments, with Walvis Bay as a case study
Published 2023“…Much research has been done on urban sustainability and urban form in the European context and is still developing. However, little research has been undertaken on the issues of urban sustainability in arid zones. …”
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