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PROTECTIVE EFFECT OF Pterocarpus mildbraedii HARMS EXTRACT ON PROPANIL-INDUCED HEPATOTOXICITY AND ALTERATIONS IN APOPTOTIC-RELATED PROTEINS IN WISTAR RATS
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Page will reload when a filter is selected or excluded.- Community pharmacists 2 results 2
- Light microscopy 2 results 2
- Malaria in pregnancy 2 results 2
- Rapid diagnostic test 2 results 2
- Technology & Engineering 2 results 2
- 6-Gingerol-rich fraction 1 results 1
- Alchornea 1 results 1
- Anti-inflammatory 1 results 1
- Apoptosis 1 results 1
- Arylsulfatase A 1 results 1
- Benzo[a]pyrene 1 results 1
- Bioengineering 1 results 1
- Biology 1 results 1
- Bladder pathology 1 results 1
- Brain 1 results 1
- Computer Programming 1 results 1
- Drying 1 results 1
- Epidermal morphology of adaxial and abaxial leaflet surfaces of the five species in the genus Dialium (Fabaceae : Caesalpinoideae) were studied by light microscopy. The epidermises are composed of cells which are isodiametric, irregular or both types in outline. Anticlinal walls are either straight, curved or undulate. Leaflets of all taxa are hypostomatic. Paracytic stomata occur in all species except D. guineense that posses both paracytic and staurocytic stomata. Other features of the epidermis that show variation include stomatal size and density, size and density of epidermal cells, and type, size, shape, frequency and basal cells of the trichomes. An indented, dichotomous key for identifying the species is presented. 1 results 1
- Exposure to benzo[a]pyrene (B[a]P) is well reported to be associated with neurological and reproductive dysfunctions. The present study investigated the influence of kolaviron, an isolated biflavonoid from the seed of Garcinia kola, on functional alterations along the brain-pituitary-gonadal axis in male rats exposed to B[a] P. Benzo[a]pyrene was orally administered at a dose of 10 mg/kg alone or orally co-administered with kolaviron at 100 and 200 mg/kg for 15 consecutive days. Administration of B[a]P significantly (p < 0.05) decreased plasma levels of pituitary hormones namely follicle-stimulating hormone (FSH) and prolactin but increased luteinizing hormone (LH) by 47%, 55% and 20.9%, respectively, when compared with the control. The significant decrease in gonadosomatic index (GSI) was accompanied by significant decrease in testosterone production and sperm functional parameters in the B[a]P- treated rats. Moreover, B[a]P - treated rats showed significant elevation in the circulatory concentrations of pro-inflammatory cytokines and oxidative stress indices in the brain, testes and sperm of B[a]P-treated rats. Light microscopy revealed severe necrosis of the Purkinje cells in the cerebellum, neuronal degeneration of the cerebral cortex, neuronal necrosis of the hippocampus and testicular atrophy in B[a]P-treated rats. Kolaviron co-treatment significantly ameliorated B[a]P mediated damages by suppressing pro-inflammatory mediators and enhancing the antioxidant status, neuroendocrine function, sperm characteristics and improving the architecture of the brain and testes in B[a]P-treated rats. The findings in the present investigation highlight that kolaviron may be developed to novel therapeutic agent against toxicity resulting from B[a]P exposure. 1 results 1
- Gastrointestinal 1 results 1
- Ginger (Zingiber officinale) is a globally marketed flavoring agent and cooking spice with a long history of human health benefits. The fungicide carbendazim (CBZ) is often detected in fruits and vegetables for human nutrition and has been reported to elicit toxic effects in different experimental animal models. The present study investigated the protective effects of 6-Gingerol-rich fraction (6-GRF) from ginger on hematotoxicity and hepatorenal damage in rats exposed to CBZ. CBZ was administered at a dose of 50 mg/kg alone or simultaneously administered with 6-GRF at 50, 100, and 200 mg/kg, whereas control rats received corn oil alone at 2 mL/kg for 14 days. Hematological examination showed that CBZ-mediated toxicity to the total white blood cell (WBC), neutrophils, lymphocytes, and platelets counts were normalized to the control values in rats co-treated with 6-GRF. Moreover, administration of CBZ significantly decreased the activities of superoxide dismutase, catalase, glutathione peroxidase, and glutathione S-transferase as well as glutathione level in the livers and kidneys of rats compared with control. However, the levels of hydrogen peroxide (H2O2) and malondialdehyde were markedly elevated in kidneys and livers of CBZ-treated rats compared with control. The significant elevation in the plasma indices of renal and hepatic dysfunction in CBZ-treated rats was confirmed by light microscopy. Coadministration of 6-GRF exhibited chemoprotection against CBZ-mediated hematotoxicity, augmented antioxidant status, and prevented oxidative damage in the kidney and liver of rats. 1 results 1
- Glutathione-S-transferase Polymorphism 1 results 1
- Graves’ disease 1 results 1
- Growth factor 15 1 results 1
- Hepatotoxicity 1 results 1
- Histopathology 1 results 1
- Kilishi 1 results 1
- Kilishi processing is time consuming, rigorous and location specific — the focus of this study was therefore to assess if the effects of using a mechanical slicer (rather than hand slicing) and oven drying (instead of sun drying) would significantly affect the product yield of Kilishi. Two kilogram each of choice trimmed beef was used in two replicates of four treatments in a completely randomized design. Treatments A, B, C, and D represents hand sliced, sun dried samples; mechanically sliced, sun dried samples; hand sliced, oven dried samples and mechanically sliced oven dried samples respectively. Meat used were chilled overnight and processed the following morning. The histological characteristics of muscle tissue used for Kilishi production as affected by drying were studied. For slice thickness, there were no significant differences between the mechanically sliced and hand sliced, sun dried products, but the oven dried products were significantly different (P<0.05). It was observed that the mechanical slicing and oven drying gave the highest yield of 65.21 %, compared to 58.66% yield from the traditional processing method. Light microscopy showed that both intracellular and extra cellular components were affected by the conditions of processing. Mechanical slicing and oven drying in Kilishi production holds an economic advantage to producers who desire higher product yield and a safer product from oven drying for consumers who relish the snack. 1 results 1
- Kolaviron 1 results 1
- Leaf epidermal morphology of the five species of Hyptis (Labiatae) in West Africa has been studied using Light and Scanning Electron Microscopy. Epidermal cells are irregular with undulate or wavy anticlinal walls or rarely polygonal with straight to curved anticlinal walls, In H. peclimilu and H. lanceolate/, the adaxial epidermal cells are either irregular or polygonal, an observation which may be accounted for by eco-geographical differences. The periclinal walls consist of irregular ridges and cuticular folds on both abaxial and adaxial surfaces. The adaxial epidermal cells are generally larger than those on the abaxial surface. All taxa have diacytic stomata and are amphistomatic with more stomata on the abaxial surfaces. Stomata may be slightly raised, level with the surface or slightly sunken. The stomata are characterised by the presence of pronounced, overarching cuticular rims. Trichomes are multicellular or rarely unicelular, uniseriate, non-glandular or glandular, unbranched and thin walled. They are usually densely or rarely sparsely distributed on both surfaces of the leaves and are covered with numerous tubercules. Trichomes vary in size and form even on the same epidermal surface of every taxon. The glands are usually globose in shape. Some characters which are of taxonomic value include the adaxial epidermal cell shape, anticlinal wall pattern, size of stomata, epidermal cell and trichome type. A key is presented for the identification of the species. 1 results 1
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