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Synthesis and investigation of benzimidazole and carbazole ß-haematin inhibiting scaffolds with antimalarial activity
Published 2018“…Cellular haem fractionation studies revealed an increase in free haem and decrease in haemozoin confirming that haemozoin inhibition is the mode of action for the benzimidazole compounds. QSAR analysis of these compounds revealed a correlation between the -Log(P. falciparum IC50) which is also known as pLog(P. falciparum IC50) and 1/βhaematin IC50, number of hydrogen bond donors and molecular depth with 1/β-haematin IC50 the most dominant term. iv The first four carbazole indole compounds were synthesized using a two-step synthesis via deprotonation of carbazole and reaction with epichlorohydrin or 1,3-dibromopropane to furnish the epoxide or alkylbromine intermediates. …”
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Fatigue Behaviour of CFRP Strengthened Reinforced Concrete Beams
Published 2020“…Information was acquired on key performance indicators that included fatigue life, crack development, failure mode and stiffness degradation, where stiffness was assessed in terms of midspan deflection, composite material strains and neutral axis shift. …”
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Cultural predictions of entrepreneurial orientation and the moderating role of entrepreneurial competencies on graduate entrepreneurial intentions: A cross-sectional survey of East...
Published 2021“…The study calls for a revision of the curriculum to include tolerance for ambiguity, proactiveness and autonomy courses in entrepreneurship education as well as a change in the mode of delivery of this subject. A transformation in the education systems of the three countries is needed to produce critical thinkers and to introduce entrepreneurship early in the education system to make everyone appreciate entrepreneurship, thus nurturing an entrepreneurial culture.…”
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Towards Sustainable Freight Energy Management - Development of a Strategic Decision Support Tool
Published 2021“…A unique and independent decision needs to be made on the application of a measure for each of these network components (for example for each mode). Decisions on freight transportation impact all three traditional pillars of sustainability: social, environmental and economic. …”
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Performance of the vertical roller mill in a mineral processing application when coupled with internal and external classifiers
Published 2022“…Vertical roller mill products of three target grinds, typical to primary, secondary and tertiary grinds in PGM circuit, were generated with the VRM operated in the standard airflow mode, with the internal dynamic air classifier, for a variety of grinding pressures (an online control used for maintaining product quality), and dam ring heights (a design variable affecting residence time on the grinding table). …”
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Developing a 'Road Safety Desert' Methodology for South Africa
Published 2024“…The supply quality data should be improved and be specific to the mode being analysed. For example, when analysing NMT ‘safety deserts', the infrastructure-related attributes should be NMT specific. …”
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Combined use of environmental and artificial tracers to characterise the anthropogenically altered vadose zone and groundwater system
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Proteolytic and amylolytic enzymes for bacterial biofilm control
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A Rutherford backscattering study on radiation damage and the diffusion of krypton implanted into 6H-SiC
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In vitro hepatotoxicity and herb-drug interactions of selected African plant extracts
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Development of novel methods for tannin quantification in grapes and wine
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Investigation into flow-induced vibrations of piano key weirs
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Thermal field-flow fractionation and the advanced analysis of complex polymers
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Flexible Co(II) metal-organic frameworks with mixed ligands under controlled pressure
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Evaluation of the influence of aeration on the discharge capacity and flow induced vibrations of Piano Key Weir spillways
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Is life to be taken seriously?
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Vinnige identifikasie van botaniese- en geografiese oorsprong van Suid-Afrikaanse heuning
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The effect of biostimulants on the performance of newly planted apple trees in fumigated soil
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