Biological activity of Sinularia notanda

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Exploiting drug synergism to extend the application of oestrone analogues

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Investigation of non-prostatic in vitro prostate-specific membrane antigen expression in MCF-7 and MDA-MB-231 breast tumour cells

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Angiogenic, apoptotic and autophagic profiling of chronic myeloid leukaemia patients’ platelets ex vivo before and after treatment with Imatinib

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Evaluating the anticancer and antioxidant activity of Southern African plants and their mechanism of action

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Establishment of recombinant antibody technologies allowing for the generation of SNAP-tag fusion proteins by Nundalall, Trishana

“…Triple negative breast cancer (TNBC's) is a highly aggressive and invasive subtype of breast cancer, typically characterised by the lack of estrogen receptor (ER), progesterone receptor (PR) and Human epidermal growth factor receptor 2 (HER2) with an inexplicable partiality towards African women. …”
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Synthesis, characterization, and anticancer activity of arene mono-ruthenium and heteroleptic mixed-valent diruthenium complexes by Medupe, Thato Tshwaro

“…To contribute towards the good health and well-being sustainable development goal, this project aims to synthesize and characterize organometallic arene mono-ruthenium and diruthenium complexes that have anti-neoplastic properties against the oestrogen receptor positive MCF-7, and the triple negative aggressive and invasive MDA-MB-231 human breast cancer cell lines. …”
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Identification of biomarkers of tumour blood vessels for therapeutic targeting

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Detecting and quantifying plasmodium falciparum in blood and tonsils: towards an understanding of malaria-related oncogenesis by Kusi, Stephen

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In vitro signal transduction mechanism exerted by 2-ethyl-3-O-sulphamoyl-estra-1,3,5(10),15-tetraen-3-ol-17-one in combination with dichloroacetic acid on breast adenocarcinoma (MC...

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Systematics of Hypoxis (Hypoxidaceae) in southern Africa

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Fumonisin exposure biomarkers in humans consuming maize staple diets by Van der Westhuizen, Liana

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The role of Lymphoblastic leukemia 1 (Lyl1) in Mycobacterium tuberculosis (Mtb) infection by Jones, Shelby-Sara Ann

“…Since its discovery in 1989, many reports have been published describing its relationship with cancer as well as demonstrating its function during hematopoiesis. …”
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Phenotypic, physico-chemical and genetic responses of maize associated with resistance to Fusarium verticillioides by Links, Stefan

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Antimicrobial and antimalarial activity of Tabernaemontana elegans Stapf. (Apocynaceae)

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An investigation into the potential cardioprotective effects of ghrelin in a rat model of chronic Doxorubicin-induced cardiotoxicity by Goldswain, Toni Leigh

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Development of a novel bioreactor and systems for suspension cell culture in biopharmaceutical production by Sharma, Rajesh

“…The second approach is to test the adaptation of adherent Vero cells into single-cell suspension culture in serum-free media by treating them with an anti-cancer drug, Puromycin amino nucleoside (PAN). The absence of a supporting surface for cell growth (e.g. microcarriers) and serum-free conditions are expected to reduce the cost of manufacturing and to achieve higher productivity of biological production per unit volume of bioreactor. …”
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Investigating the role of a FAM111B mutation in hereditary fibrosing poikiloderma (POIKTMP) using induced pluripotent stem cell (iPSC) model by Gumede, Dimakatso B

“…Future work will also explore the gain-of-function hypothesis to further understand the role of FAM111B in fibrosis and cancer phenotype in POIKTMP.…”
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Characterization of antifungal compounds isolated from Combretum and Terminalia species (Combretaceae)

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A comparative analysis of the G1/S transition control in kinetic models of the eukaryotic cell cycle by Conradie, Riaan

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