The effect of hypoxia on protein phosphatase 2A (PP2A) in MDA-MB-231 cells, and, a pilot study to establish a primary breast cancer cell model from Fine Needle Aspirations. by Patten, Victoria Alexandra

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Cancer modulating properties of unique South African herbal teas (rooibos and honeybush) in short term in vitro and in vivo carcinogenesis assays by Marnewick, Jeanine Lucasta

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Synthesis of novel Tetrahydroisoquinoline-related estrogen receptor modulators by Mabank, Tanya

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A description of the profile of paediatric brain tumours in a tertiary neurosurgery service

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Analysis of the clinical utility of gene expression profiling in relation to conventional prognostic markers in South African patients with breast carcinoma by Grant, Kathleen Ann

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The functional impact of a rare germline TP53β N340D variant identified in breast cancer patients with the Li-Fraumeni-like syndrome by Christowitz, Claudia

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Proteomic characterisation of primary breast tumour extracellular matrix

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Synergistic cytotoxicity of Solanum aculeastrum with 4-hydroxytamoxifen in the MCF-7/TAMR-1 breast adenocarcinoma cell line

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Investigating the effects of progestins used in contraception and menopausal hormone therapy on aromatase expression and activity by Janse van Vuuren, Melani

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Characterising the anticancer effects of a small molecule with potential to inhibit nuclear import via karyopherin beta1 by Mkwanazi, Nonkululeko

“…C53 treatment significantly inhibited proliferation in cancer cell lines. The reduction in proliferation in cancer cells was associated with a block in the G1 phase of the cell cycle and a change in the expression of cell cycle related proteins such as CyclinD1 and CDK4. …”
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Aqueous extracts of Dodonaea viscosa induce potent and selective cytotoxicity in DLBCL cells by Yekelo, Babalwa

“…The effect of proliferation was further confirmed through a colony-forming assay, which showed potent inhibition of colony formation over 7 days, by DVE, for both cancer cell lines. …”
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The role of BCLFA1 in cellular transformation by Shipanga, Hendrina

“…Although the role of BCLAF1 is not well defined, some studies have shown BCLAF1 to have functional connections linked to some of the known hallmarks of cancer such as cell proliferation, apoptosis and genome stability, thus linking BCLAF1 to cellular transformation. …”
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The biological effects of HIV-1 Nef on the development of B-cell Lymphoma by Ahmed, Riyaadh

“…Future studies will focus on further defining the oncogenic potential of Nef in aggressive B-cell lymphomas by examining its effect on other oncogenic processes/pathways which define hallmarks of cancer, including cell migration and invasion, autophagy and angiogenesis, as well as its effect on oncogenic signalling pathways. …”
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An investigation into the role of TBX3 in breast carcinogenesis and its regulation by the TGF-?1 signalling pathway by Li, Jarod Ang

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Overexpression of cofactor of BRCA1 in HepG2 cells: A step towards understanding the role of COBRA1 in hepatocellular carcinoma by Masad, Razan Jamil

“…The transfection efficiency was determined by the percentage of EGFP positive cells (pEGFP-N1+) via fluorescent microscope, semi-quantitative RT-PCR as well as western blot analysis. The cells proliferation and migration following COBRA1 overexpression were assessed using the trypan blue dye exclusion method and the wound-healing assays respectively. …”
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Cofactor of BRCA1 as a modulator of hepatocellular carcinoma growth and migration by El Zeneini, Eman Mahmoud

“…As such, COBRA1 is able to regulate a substantial number of genes involved in a number of pathways, including cell cycle control, metabolism, cell proliferation and DNA repair. In the field of cancer, the role of COBRA1 is not yet fully understood. …”
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Investigation of vasculogenic mimicry in melanoma tissue

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Exploiting drug synergism to extend the application of oestrone analogues

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Characterizing the role of p21-Activated Kinase 3 (PAK3) in AP-1-induced transformation by Holderness-Parker, Nina Alison Victoria

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Analysis of the bacterial microbiome from prostate tissue of South African men

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