Expression and regulation of N-Myc Downstream- Regulated gene 1 in squamous cell carcinoma of the oesphagus by Bracher, Jacqueline Claire

“…In this study, real-time RT-PCR and immunohistochemistry described the overexpression of N-Myc Downstream-Regulated Gene 1 (NDRG1) in oesophageal squamous cell carcinoma (OSCC) tissue compared to normal tissue in a cohort of South African cancer patients. Despite more than ten years of research into the role of NDRG1 in cancer, the precise function of this protein remains enigmatic. …”
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Biochemical characterisation of putrescine and spermidine uptake as a potential therapeutic target against the human malaria parasite, Plasmodium falciparum

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Radiosensitising efficacy of histone deacetylase inhibitors CUDC-101 and SAHA in breast cell lines

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Selective cytotoxicity of Crotalaria agatiflora subspecies agatiflora Schweinf

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Anti-HIV, anticancer and antioxidant activity of Fockea multiflora extracts

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Bioactivity of marine organism-derived natural products

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Angiogenic, apoptotic and autophagic profiling of chronic myeloid leukaemia patients’ platelets ex vivo before and after treatment with Imatinib

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Investigating the role of a FAM111B mutation in hereditary fibrosing poikiloderma (POIKTMP) using induced pluripotent stem cell (iPSC) model by Gumede, Dimakatso B

“…Growth curves were then carried out to investigate if the FAM111B mutation modulates cell proliferation and it was found that patient cells proliferated at a higher rate compared to controls. …”
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Generation of Glioblastoma specific SNAP based antibody fusion proteins for future radiolabelling application by Mayuni, Grace

“…Each year, Central Nervous System (CNS) cancers affect about 300,000 individuals globally, accounting for 1-2% of all adult cancer cases. …”
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Molecular Characterisation of Diffuse Large B-cell Lymphoma in South Africa by Ramorola, Beatrice Relebogile

“…This was further corroborated by gene set and pathway enrichment analyses, which highlighted factors involved in the enhancement of cancer-promoting processes such as proliferation, migration, invasion, and metastasis. …”
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In vitro signal transduction mechanism exerted by 2-ethyl-3-O-sulphamoyl-estra-1,3,5(10),15-tetraen-3-ol-17-one in combination with dichloroacetic acid on breast adenocarcinoma (MC...

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An investigation into the P13-K/AKT signalling pathway in TNF-a-induced muscle proeolysis in L6 myotubes by Sishi, Balindiwe J. N.

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Identification of biomarkers of tumour blood vessels for therapeutic targeting

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Human immunodeficiency virus (HIV) and Human papillomavirus (HPV) infection and cell cycle regulators in preinvasive lesions and invasive carcinomas of the anus by De Jager, Louis Johann

“…There was a significant difference in Bcl-2 expression among normal, dysplastic and cancerous tissue (p=0.02). There was no significant difference in the Ki-67 proliferation index amongst the different subtypes of squamous cell carcinoma and the degrees of differentiation. …”
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Structure-based drug discovery against a novel antimalarial drug target, S-adenosylmethionine decarboxylase/ornithine decarboxylase

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Anti-angiogenic effects of chemotherapeutic agents and their enhancement with OT-515 and S-NACH by Heikal, Shimaa Adel

“…Cisplatin and Doxorubicin are among the well-known chemotherapeutic drugs that showed efficacy against various types of cancers. …”
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An investigation into the potential cardioprotective effects of ghrelin in a rat model of chronic Doxorubicin-induced cardiotoxicity by Goldswain, Toni Leigh

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A tumour suppressor role for the T-box transcription factor TBX3 in fibroblasts by Cooper, Aretha

“…TBX3, a member of the developmentally important T-box transcription factor family, has been shown to be overexpressed and to behave as an oncogene in several cancers. Much of this work has, however, been performed in carcinomas of epithelial origin and little is known about the role ofTBX3 in sarcomas of mesenchymal origin. …”
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Fumonisin exposure biomarkers in humans consuming maize staple diets by Van der Westhuizen, Liana

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Investigation of the expression of pro-angiogenic markers in cutaneous tumours in vivo and in vitro

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