Characterization of efflux pumps genes involved in second-line drug resistance of tuberculosis

Get full text

Selectively modifying the interaction of human Tuba SH3-6 domain with listerial InlC and N-WASP

Get full text

Evaluating the predictive performance of cytotoxic T lymphocyte epitope prediction tools using Elispot assay data by Meraba, Rebone Leboreng

“…Computational T-cell epitope prediction tools have been previously devised to predict potential human leukocyte antigen (HLA) binding peptides from protein sequences. …”
Get full text

Investigating nuclear transport proteins as secreted cancer biomarkers by Okpara, Michael Obinna

“…Venn Dis JavaFX-based Venn and Euler diagram software was used to identify common and unique Kpnβ1 binding partners. 38 proteins were identified as common binding partners of Kpnβ1 in normal and cancer cells and 56 common binding partners of Kpnβ1 in the three cancer cell lines. …”
Get full text

Development and Characterization of recombinant immunotoxins for cervical carcinoma by Henry, Marc

“…Immunotoxins are fusion proteins that consist of an antibody that binds specifically to the cancer cell connected to a protein toxin capable of killing the cell. …”
Get full text

Reducing fumonisin exposure in African fermented maize-based foods with lactic acid bacteria

Get full text

Comparison of the therapeutic efficacy of SNAP-tag fusion protein and the synergistic actions of chemotherapy and photodynamic therapy in killing resistant melanoma by Biteghe, Fleury Augustin Nsole

“…All scFv-SNAP-fusion proteins were specifically bound to their target cells, indicating that AURIF conjugation did not compromise the binding activity of scFv-SNAP fusions. …”
Get full text

Comparative study of the molecular mechanism of action of the synthetic progestins, Medroxyprogesterone acetate and Norethisterone acetate by Africander, Donita Jean

Get full text

Development and characterisation of a heparinised fibrin hydrogel as a delivery vehicle for regenerative medicine by Ngcobo, Silindile

“…Despite these differences, both FH and FPH were antithrombotic as determined by the attached heparin completely impeding clot formation for the duration of analysis (2 hours) with thromboelastography, as compared to whole blood, fibrinogen, and FP which formed clots within 1.4 ± 0.1, 1.5, and 1.3 ± 0.1 min respectively. All the hydrogels were biocompatible, with viability percentages not less than 70% after three days of 3D culture for all three cell lines evaluated, namely human umbilical vein endothelial cells (HUVECs), human dermal fibroblasts and adipose tissue-derived stem cells (ADSCs) as indicated by live/dead assays. …”
Get full text

The role of the chicken gonadotropin-releasing hormone receptor C-terminal tail in expression and coupling by Lopes, John

“…The loss of gonadotropin-releasing hormone binding by the cS320STOP-truncated mutant suggests that this receptor is possibly not expressed on the cell membrane, which might be due to improper receptor folding by cS320STOP. …”
Get full text

In vivo and in vitro regulation of plasminogen activator inhibitor type-1 by Keeton, Mark R

“…The human leukaemic cell line, K562 can be induced to differentiate along the megakaryoblastic pathway by the addition of phorbol myristate acetate and, during this process, the cells switch from producing a mixture of active tissue plasminogen activator (t-PA) and urokinase (u-PA) to producing active u-PA alone. …”
Get full text

Gold compounds with anti-HIV and immunomodulatory activity

Get full text
Get full text

Insulin, added to nuclei, stimulates transcription of specific genes by Stickells, Brenda Jane

Get full text

Transmembrane glycoprotein gp41 of the Human Immunodeficiency Virus Type I : gene synthesis, recombinant expression and immunological characterization

Get full text
Get full text

Development of real-time reverse transcription polymerase chain reaction assays to quantify insulin-like growth factor-1 receptor and insulin receptor expression in equine tissue

Get full text
Get full text

Investigating the effects of RBBP6 gene expression on telomerase activity in cervical cancer

Get full text

Generation and characterization of HIV-1 subtype C candidate vaccines that will induce high titre antibody responses to HIV-1 envelope glycoprotein by van Diepen, Michiel Theodoor

“…Nonetheless, AlhydroGel was selected as the best protein adjuvant for all further rabbit immunogenicity studies. Furthermore, in all subsequent experiments, soluble trimeric Env was used as a protein vaccine. …”
Get full text

A novel application of affinity biosensor technology to detect antibodies to mycolic acid in tuberculosis patients

Get full text
Get full text

The impact of neutralizing antibody and ADCC responses on HIV-1 envelope evolution in early infection by Mielke, Dieter

“…In addition, a nonlinear relationship was found between ADCC activity and strength of mAb binding to the infected cell surface (rs = -0.5309, p=0.0001). …”
Get full text