Genetic manipulation of unique transcription factors in Plasmodium falciparum

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Elaboration of 4′-Phosphopantetheine Adenylyltransferase inhibitors and Benzoxaboroles as antimalarial agents by Morake, Mokhitli

“…These three series were all found to have no gametocytocidal activity against the early and late stages of gametocyte development and were noncytotoxic against mammalian CHO and HepG2 cell-lines at the maximum concentration tested (IC50's >50 µM). …”
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An investigation of the potato eIF4E isoforms as targets for non-transgenic CRISPR/Cas9 genome editing for viral resistance by Hurst, Rebecca

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Architecture and assembly of maize streak virus: insights from 3D electron microscopy by Dent,Kyle Clayton

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Characterisation of Kaposi's sarcoma-associated herpesvirus (KSHV)-driven pathology and disease outcome in HIV infected South African patients by Blumenthal, Melissa

“…These engineered cells were assessed for baseline EPHA2 phosphorylation levels and susceptibility to KSHV infection utilising recombinant KSHV in binding, internalisation and infection assays. …”
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Genetic engineering of recombinant anti-mycolic acid antibody fragments for use in tuberculosis diagnostics

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Novel recombinant anti-mycolic acid immunoglobulin tools for improved understanding and management of tuberculosis

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Investigation of Neurexin 2 as a candidate for Parkinson's Disease by Cuttler, Katelyn

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The influence of sutherlandia frutescens on adrenal steroid hormones and downstream receptor interactions by Sergeant, Catherine Anne

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Male genital tract versus blood HIV-1 compartmentalization and selection: the first step of the transmission bottleneck? by Kariuki, Samuel Mundia

“…The change in envelope conformation over movement from blood into the genital tract presumably affected the maraviroc binding site and not PSC_RANTES. All the clones from blood and semen for the three most viral compartmentalized donors were resistant to CXCR4 inhibitor suggesting that they were all R5 tropic viruses. …”
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Analysis of genes and enzymes involved in the degradation of cellulose and proteins by Butyrivibrio fibrisolvens H17c by Berger, Eldie

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Towards a rapid immuno-test for tuberculosis: Immunochemical characterisation of a suitable mycolic acid antigen preparation

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Pilot study into the molecular mechanisms of canine distemper virus infection

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Profiling of the secondary metabolites and the characterization two novel antilisterial peptides, xenopep and rhabdin, produced by xenorhabdus khoisanae by Booysen, Elzaan

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Functional role of non-structural protein NS4 in the African horse sickness virus infection cycle

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Investigating progesterone and estrogen receptor crosstalk in breast cancer by Van der Meer, Yolandi

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Potential role of cofactor of BRCA1 in hepatocellular carcinoma pathogenesis by Youssef, Aya Atef

“…The other NELF subunits (A, C/D and E) mRNAs were co-dependently expressed in all the tested cell lines. In the three HCC cell lines (HepG2, SNU-449 and SNU-387), c-Fos was expressed in its active phosphorylated form in contrast to c-Jun which was not detected in its active form. …”
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Characterization of normal adipose tissue and pansteatitic tissue in the nile crocodile (crocodylus niloticus) : possible mechanism(s) of pathogenesis and pathophysiology

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Some characteristics of the uterine progestorone receptor and the effects of norethindrone on conception in the rock hyrax (Procavia capensis)

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An Investigation of the SHIV reservoirs in the lymphoid organs of HIV-vaccinated rhesus monkeys after SHIV challenge by Benn, Kealan Timothy

“…RNA viral loads were low for all animals with the median of the averages of the viral load for PBMCs being 3.82 copies/107 cells and a range of < 1 copies/107 cells to 61.15 copies/107 cells. …”
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