Visualising the Mycobacterial Mutasome by Reiche, Michael Anton

“…Using fluorescence microscopy, it was observed that, during prolonged genotoxic stress, single M. smegmatis cells exhibited an elongated cell phenotype and apparent aneuploidy – potentially providing an environment for recombination between differentially mutated chromosomes. …”
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The mycosins, a family of secreted subtilisin-like serine proteases associated with the immunologically-important ESAT-6 gene clusters of Mycobacterium tuberculosis by Gey van Pittius, Nicolaas Claudius

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Development of potential immunodiagnostic & therapeutic techniques using SNAP-fusion proteins as tools for the validation of Triple-negative Breast Cancer by Magugu, Freddy-Junior Siybaulela

“…First functionalities of two scFv SNAP fusion proteins and one VHH SNAP fusion protein previously not having been described are provided through binding analyses on receptor positive tumour cell lines. …”
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Synthesis and biological evaluation of salicylaldimine complexes based on an alkylated PTA scaffold by Cassells, Irwin

“…All of the metal complexes were evaluated against the MCF7 breast cancer cell line. The ruthenium and iridium salicylaldimine complexes showed comparable or greater cytotoxicity than cisplatin at 20 µM against the MCF7 cancer cells, as well as greater cytotoxicity than their rhodium counterparts. …”
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Development of a fluorescent quantum dot-mycolic acid probe for use in Mycobacterium tuberculosis antibody detection

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The regulation of the T-box transcription factor TBX3 in Luminal A breast cancer by Ncube, Stephanie Maria

“…This study shows that inhibiting the AKT pathway in MCF-7 and T47D breast cancer cells using a commercially available AKT inhibitor as well as a dominant negative AKT results in a decrease in TBX3 protein levels. …”
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Development of copper peptide complexes as anti-Inflammatory drugs by Hammouda, Ahmed N H

“…The structures of the complex species were investigated using ultraviolet-visible (Uv-Vis), nuclear magnetic resonance (NMR), electrospray ionisation mass spectrometry (ESI-MS) spectroscopy as well as molecular mechanics (MM) calculations. The visible spectra obtained for the different species in solution were typical of Cu(II) and Ni(II) complexes. 1H NMR identified the active binding sites to be the imidazole nitrogen, the amide nitrogen and the terminal amino group. …”
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Characterizing the role of p21-Activated Kinase 3 (PAK3) in AP-1-induced transformation by Holderness-Parker, Nina Alison Victoria

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Identification of South African fungi with high protein secreting capabilities

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Stimulation of angiogenesis through growth factor delivery from synthetic heparinised hydrogels by Chokoza, Cindy

“…In this study, enzymatically degradable heparinised polyethylene glycol (PEG-Hep) hydrogels were synthesized and characterised for the binding and controlled release of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), as well as their bioactivity and angiogenic potential in vivo. …”
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Genetic manipulation of unique transcription factors in Plasmodium falciparum

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Identification of novel ligands of WDR47, using yeast two-hybrid analysis by McGillewie, L.

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Bioactivity of marine organism-derived natural products

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Interaction of nonstructural protein NS3 of African horsesickness virus with viral and cellular proteins

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The crystal structure of an aliphatic amidase from Geobacillus pallidus RAPc8 by Kimani, Serah

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Amphotericin B as a mycolic acid specific targeting agent in tuberculosis

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PVP bioconjugates of membrane disruptive peptides by Jokonya, Simbarashe

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Investigation of Neurexin 2 as a candidate for Parkinson's Disease by Cuttler, Katelyn

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Identification of the genes encoding enzymes involved in the synthesis of the biopolymer paramylon from Euglena gracilis by Mackay, Stephen

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Evaluation of the bioactivity and stability of gold nanoparticles conjugated with Os-C(W5) against Candida albicans biofilms

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