In vitro study of in silico designed sirtuin 1 and bromodomain 4 inhibitors on human neuroblastoma SH-SY5Y and acute myeloid leukemia U937 cells

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Examining plasminogen activator-inhibitor-1 and C-reactive protein regulation by glucocorticoids and pro-inflammatory cytokines in liver cell lines by Dale, Lieke

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Ironing out haemochromatosis : a study of an Indian family by Hallendorff, Michelle-Angelique

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Analysis of sugar accumulation under cold stress in Physcomitrium patens by Jacobs, Desren Brando

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Dynamic interactions between skeletal muscle and breast cancer cells following chemotherapeutic treatment by Conradie, Daleen

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Peripheral control tools for a run-of-mine ore milling circuit

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Polyketide Synthase III isolated from uncultured deep-sea Proteobacterium from the Red Sea- functional and evolutionary characterization by El Bardisy, Hadeel Mansour

“…Preliminary structural analysis showed well-fitted superimposition with the flowering plant Medicago sativa PKS type III crystal structure and predicted the interaction of the catalytic triad with the most common substrate malonyl-CoA. Further optimization of heterologous expression is required to investigate this isolated PKS type III functional activity. …”
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Voluntarism, values and community : an intersubjective reading of Bas C. van Fraassen's The empirical stance by Braae, Elizabeth

“…Choosing between stances is not a matter of reason or rational compulsion; rather, we choose the stance that best reflects or expresses our values. For Dien Ho and Anja Jauernig, however, this reduces philosophy to a subjective expression of personal preference (subjectivism) and, moreover, reduces philosophical debate to an irresolvable value-based dispute (relativism). …”
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The legitimacy of dismissals for off-duty misconduct in South African labour law

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Molecular characterisation of the gene, LGALS13, and its putative involvement in pre-eclampsia by Postma, Alisa

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Investigating the multifaceted host contribution to COVID-19 disease risk, progression and treatment: an integrative multi-omics network-based approach study by Agamah, Francis Adem

“…The clinical presentation of COVID-19 is very heterogeneous, ranging from mild disease states to severe disease states, associated with varying transcription, protein expression, lipid synthesis, and metabolic profiles. …”
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Comparison of Xpert® Breast cancer STRAT4 assay and immunohistochemistry for the evaluation of breast cancer biomarkers in South African patients by Dube, Welile Vumile

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The relationship between HIF-1α and autophagy activity in the hypoxic environment of breast cancer by Mills, Justin

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Efficacy and mechanism of action of intrahippocampalD-cycloserine in an animal model of Posttraumatic Stress Disorder (PTSD) by Fairbairn, Lorren Rosli

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The relationship between BRAF genetic alterations and the risk of tumour recurrence in Pilocytic Astrocytomas in children diagnosed at Red Cross Children's Hospital over a 33-year... by Viljoen, Nandi

“…This was done by evaluating the expression of BRAF using immunohistochemistry (IHC), fluorescence-in-situ hybridisation (FISH) and polymerase chain reaction (PCR) and comparing it to tumour recurrence. …”
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The relationship between p53 mutations and differential sensitivity to anti-cancer drugs in oesophageal cancer cell lines by Johnson, Melanie

“…In South Africa, cancer of the oesophagus is the leading cause of death in black males and overall the fourth most common cancer. Development of resistance to chemotherapeutic agents hinders the successful treatment of several cancers. …”
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Host somatic variation between women living with HIV with cervical intraepitheial lesions (CIN3) and their HIV negative counterparts by Mabizela, Nosipho

“…These parameters were statistically significant when compared to HIV-positive cohort. Common HPV types identified were HPV 16 (43/88, 49%), 35 (12/88, 14%), and 58 (10/88, 11%). …”
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Effects of prenatal exposure to genistein on learning and memory function in Sprague Dawley rat offspring

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Henri-Pierre Roché : Á la recherche de I' unité perdue

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