Isolation and characterization of African marine natural products and repositioning of the natural product antibiotic fusidic acid and privileged benzimidazole scaffold for tubercu... by Dziwornu, Godwin Akpeko

“…The compounds displayed low micromolar to poor in vitro antiproliferative activity towards the human breast (MDA-MB-231) and cervical (HeLa) cancer cell lines with IC50 values in the 8.8 – 133.8 µM range. …”
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Shape Memory Alloy Capsule Micropump for Drug Delivery Applications by Kotb, Youssef Mohamed

“…The system was successfully implemented, tested in vitro, and proven to deliver a model anticancer drug accurately and achieve a cytotoxic effect on breast cancer cells (>71%) with an optimized remotely controlled bolus dosing regimen. …”
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Advancing tuberculosis treatment through pharmacometric modeling of drug exposure and biomarkers by Wijk, Marie Sjölin

“…Optimizing therapy requires more reliable biomarkers and a better understanding of risk factors to enable individualized treatment approaches. In this thesis, I utilized pharmacometric modelling and data from drug-susceptible pulmonary tuberculosis patients as well as in vitro data to characterise the pharmacokinetics (PK) and pharmacodynamics (PD) of first-line anti-tuberculosis drugs and tuberculosis biomarkers. …”
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Design, synthesis and biological evaluation of bioorganometallic metallarectangles by Golding, Taryn

“…Furthermore, the new quinoline-containing compounds were evaluated for their in vitro anticancer activity in MCF-7 and MDA-MB-231 breast cancer cell lines. …”
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The role of the tumour microenvironment components in cancer cell behaviour and drug response by Senthebane, Dimakatso Alice

“…This study investigated the interactions between cancer cells and the stroma within the TME, specifically fibroblasts, mesenchymal stem cells (MSC), cancer stem cells (CSCs) as well as the extracellular matrix (ECM), with the goal to develop an in vitro model that mimics solid tumours in terms of cellular characteristics and drug response. …”
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Design of an impedance guided intra-arterial catheter by Schwartz, Paul

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Mitigation of intrarenal pressure in retrograde intrarenal surgery with a novel isoprenaline eluting guidewire by John, Jeff

“…The porcine model has frequently been utilized by researchers and urological surgeons for medical advancements. …”
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Anthracycline-induced cardiotoxicity : the role of proteolytic pathways by Sishi, Balindiwe J. N. (Balindiwe Jennifer Nonkosazana)

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Comparing biochemical and biophysical methodologies for the characterization of induced cell death

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Development and characterisation of a heparinised fibrin hydrogel as a delivery vehicle for regenerative medicine by Ngcobo, Silindile

“…Both FH and FPH further prolonged and sustained bFGF and VEGF release in-vitro relative to their unheparinised counterparts. …”
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Investigating the production of a particulate plant-produced vaccine candidate against African horse sickness by Luhanga, Gloria

“…In vitro coupling involved carrying out separate infiltrations and purification of pEAQ-STAP205 VLPs and pEAQ-AHSV 5 VP2domSC in plants and thereafter mixing the purified products. …”
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Isolation and characterization of human adipose derived mesenchymal stem cells and production of GFP-labeled primary cells for in vivo tracking following transplantation

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Characterisation of umbilical cord blood derived haematopoietic stem and progenitor cells from HIV exposed infants that are HIV negative at birth

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Manipulation of macrophage phagocytosis - development of an endogenous delivery system by Visser, Johan Georg

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Intra-articular bupivacaine : a literature review including a pilot study investigating the safety of intra-articular bupivacaine to chondrocytes by Van der Merwe, Willem Jacobus

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Proteomic studies on patient responses to chemotherapy, radiotherapy and immunotherapy in cancers by Duarte, Jessica Da Gama

“…In addition, we sought to cross-correlate our protein microarray data from specific cohorts with in vitro T-cell re-stimulation assays for a selected subset of patients. …”
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The effect of exogenous protease on the relative enzyme activity of β-glucosidase in oenological conditions by Swart, Elsa Marita

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Characterization of pigment production by Escherichia Coli containing a cloned Rhodococcus gene by Hart, Stephen Lewis

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The occurrence and wastewater chlorination fate of selected pharmaceuticals in South African surface water

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Toxic mitochondrial effects induced by "red devil" chemotherapy by Opperman, Caleigh Margaret

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