Expression optimization of a human papillomavirus type 16 therapeutic vaccine candidate in Nicotiana benthamiana leaves by Do Rosario Yanez, Romana de Jesus

“…This was done by expressing LALF-E7 using different expression vectors, testing different subcellular localizations, and testing the effect of gene silencing suppressors. …”
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Die identifikasie en gebruike van polimorfiese mikrosatellietvolgordes in genetiese kartering [Microfiche] by Groenewald, I. M

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Controls of hydrothermal fluid flow and gold mineralization in the Twin Hills deposit and adjoining areas, Central Zone, Damara Belt by Shilunga, Josia Tulongeni

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Circadian rhythms as novel chemotherapeutic strategies for breast cancer by Mitchell, Megan Irvette

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Antimalarial benzimidazoles and related structures incorporating an intramolecular hydrogen bonding motif: medicinal chemistry and mechanistic studies by Attram, Henrietta Dede

“…While this suggests that the nucleus may not be a site of action for antiplasmodium activity, incorrect localization due to the NBD tag cannot be excluded. Based on the results from the live-cell imaging where both fluorescent probes accumulated in acidic organelles like the digestive vacuole and the neutral lipid bodies that have been implicated in hemozoin formation, it was hypothesized that the parent compounds 1.3 and 3.14 could be inhibiting the formation of hemozoin. …”
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Developing pet infection imaging agent for visualizing bacterial peptidoglycan assembly

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Evaluation of optical techniques applied to online turbomachinery blade vibration measurements

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Differences in callosal and subcortical volumes and associated neurobehavioural deficits in children with prenatal alcohol exposure by Biffen, Stevie Crystal

“…Certain high-risk communities in the Western Cape Province of South Africa where heavy maternal prenatal alcohol consumption is perpetuated by historical and societal challenges, have some of the highest prevalence rates of fetal alcohol syndrome (FAS) in the world. …”
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The response of the central auditory nervous system to sound in normal hearing adults with and without HIV/AIDS : an fMRI study

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Nonlinear singular spectrum analysis and its application in multivariate statistical process monitoring by Krishnannair, Syamala

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The role of glycogen synthase kinase-3 (GSK-3) protein in the development of myocardial hypertrophy in a rat model of diet induced obesity and insulin resistance by Lubelwana Hafver, Tandekile

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Investigations of the role of myomegalin in the phosphorylation of cardiac myosin binding protein C by Uys, Gerrida Mathilda

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Long QT syndrome : the identification and verification of putative KCNE2-interacting proteins by Neethling, Annika

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Retrospective review: diagnostic performance of PI-RADS V2.1 4 and 5 lesions in predicting clinically significant prostate cancer at Groote Schuur Hospital, South Africa by Wegner, Brett

“…Groote Schuur Hospital (GSH) radiology division has been reporting prostate mpMRI according to the updated PI-RADS v2.1 since its introduction in 2019, however no studies have been performed to assess the reliability of PI-RADS v2.1 at GSH for detecting clinically significant prostate cancer. …”
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Magma accumulation and segregation during regional-scale folding : the Holland’s dome granite injection complex, Damara belt, Namibia. by Kruger, Tolene Mia

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Optimization of production methods for gallium-68 PET radiopharmaceuticals in a hospital radiopharmacy by Le Roux, Johannes Stephanus

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The molecular epidemiology of mycobacterium tuberculosis : role in understanding disease dynamics in high prevalence settings in Southern Africa region by Chihota, Violet

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Mechanism of Action Studies of Phenotypic Whole-cell Active Antimalarial Leads Through Target Identification by Korkor, Constance

“…Over the past century, potent antimalarial drugs with different mechanisms of action have been successfully developed and used to treat malaria. …”
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Elucidating the Smurf1- and other E3 ligase-mediated ubiquitination of mycobacterial proteins by De Buys, Keren

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Ligand-receptor interactions of Gonadotropin-releasing hormone antagonists by Assefa, Daniel

“…In Summary, molecular determinants of the binding of peptide and non-peptide antagonists to the GnRH receptor have been investigated in the present thesis. The major findings are: (1) The identification of a peptide GnRH antagonist with differential affinity between human and sheep GnRH receptors, which could be used in future studies to map its binding site. (2) The identification of a set of residues which contribute to the differential affinity of the non-peptide GnRH antagonist FE 101177 towards sheep and human receptors. (3) The synthesis and chracterization of PAnt-1, a novel photoreactive peptide GnRH antagonist with high affinity and cross/inking efficiency (4) The localization of the attachment site of PAnt-1 to a 7-residue segment of the Nterrninal domain of the receptor, with Cys14 the putative cross/inking site.…”
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