Development of recombinant immunotoxins targeting overexpressed cell surface biomarkers trophoblast cell-surface antigen 2 and mesothelin for cervical cancer treatment by Masuku, Sizalobuhle

“…Medical Biotechnology & Immunotherapy Research Unit Institute for Infectious Disease & Molecular Medicine South African Research Chair in Cancer Biotechnology ETA represents the wild type (wt) of Pseudomonas exotoxin A, a highly cytotoxic protein toxin produced by a bacterium that inhibits protein synthesis in host cells leading to cell death. dETA version of ETA being the modified form of the toxin generated using a supercomputing-based molecular dynamics simulation model to identify point mutations that minimize the risk of an immune response in patients while maintaining the cytotoxic activity of the wild type (wt) ETA. …”
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UF membranes operated on paper machine wastewater : fouling tendencies and characterisation by Domingo, Garth Selby

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Programmed cell death-ligand 1 (PD-L1) expression in HIV-associated diffuse large B-cell lymphoma – role and regulation by Latib, Zahra

“…Diffuse Large B cell Lymphoma (DLBCL) is an aggressive disease that displays striking heterogeneity at both the molecular and clinical levels; and as a result, up to 40% of patients relapse or are refractory to standard first-line therapy. …”
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The mechanism of resistance to Xanthomonas vasicola pv musacearum explored in Musa balbisiana

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Mechanisms and measurements of sialidase in pneumonia by Coetzee, Carla

“…Two in-silico methods were used to verify the experimental results: molecular modelling and molecular docking. Molecular modelling was used to calculate the free energy of the reaction between NanA and MUANA and to compare to the free energy obtained by the experimental data. …”
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Metallophiles as sources of antimycobacterial agents by Nyambo, Kudakwashe

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Catalytic oxidation of lignin model compounds by Maggott, Emile Darron

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Analytical approaches for haloacetic acid disinfection byproducts in treated water

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Machine learning and network-based approaches unveil key aspects of gene regulation that drive Plasmodium falciparum pathogenesis

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Quinoline-triazole half-sandwich iridium(III) complexes: Synthesis, antiplasmodial activity and preliminary transfer hydrogenation studies by Melis, Diana

“…Single crystal X-ray diffraction confirmed the proposed molecular structure and a pseudo-tetrahedral geometry around the metal centre for the cyclometallated and monodentate, quinoline nitrogen-coordinated complexes. …”
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Mapping and restructuring of an Ae. kotschyi derived translocation segment in common wheat by Heyns, I. C.

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The development and characterisation of grapevine virus-based expression vectors by Du Preez, Jacques

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Strategic pre-clinical development of Riminophenazines as resistance circumventing anticancer agents

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Exploring the antimicrobial and antifouling properties of secondary metabolites produced by serratia marcescens by Clements, Tanya Lee

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The impact of B-cell activation on the T-cell immune response to Mycobacterium tuberculosis by Van Rensburg, Ilana Claudia

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Ferrocene sulfonyl derivatives as antimycobacterials by McMaster, Erin Cullen

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Bioactive compounds inspired by nature : synthesis, stability & delivery by Van der Westhuyzen, Alet E.

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Theology in the flesh : exploring the corporeal turn from a southern African perspective

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Characterisation of citrus tristeza virus-induced stem pitting in citrus by Aldrich, Dirk Jacobus

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Oxygen transfer in hydrocarbon-aqueous dispersions and its applicability to alkane-based bioprocesses by Correia, Leslie Daniel Camara

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