Functional characterisation of gonadotropin-releasing hormone-estrogen conjugates

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Transient biolistic transformation in maize leaves

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HPV pseudovirion production in plants by Kennedy, Paul

“…While this is an effective method of PsV production, mammalian cell culture is expensive and time-consuming. Transient recombinant protein expression in plants offers a rapid and cost-effective alternative to mammalian cell culture. …”
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The role of IL-4Rá in Nippostrongylus brasiliensis-induced chronic lung pathology by Basich, Dinko

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Characterisation of galactinol synthase II (XvGolSII) from the resurrection plant Xerophyta viscosa (Baker) by Neumann, Alexis Joy

“…Subcellular localisation examination, using an XvGolSII-YFP fusion protein, indicated localisation to the cell membrane of onion epidermal cells. Quantitative real time PCR analysis showed XvGolSII to be significantly down-regulated during dehydration stress while mildly up-regulated during the early stages of cold stress, though the latter increase was not significant. …”
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Development of aminoquinoline-benzimidazole hybrids and their organometallic complexes as antimicrobial agents against Plasmodium falciparum and Mycobacterium tuberculosis by Baartzes, Nadia

“…In addition, reactive oxygen species (ROS) generation by this ferrocenyl hybrid was explored using a DNA-cleavage assay, revealing insignificant ROS-generating ability. …”
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Genetic effects of prolonged UV-B exposure in a Namaqualand daisy - Dimorphotheca sinuata by Mpoloka, Sununguko Wata

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The effect of mycobacterial mycolic acids on the cytokine profile of the immune response in murine tuberculosis

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Spatial and temporal regulation of IL4Rα expression by Smith, Elizabeth M

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Treatment-resistant ophthalmoplegia in Myasthenia gravis: extraocular muscle pathology, the role of TGFβ1 and the derivation of induced pluripotency towards 'disease-in-a-dish' mod... by Rautenbach, Robyn Marié

“…Finally we investigated the feasability of establishing an in vitro disease model for MG or OP-MG by reprogramming dermal fibroblasts into disease phenotype-specific induced pluripotent stem (iPS) cells. We successfully generated and characterised iPS cells for one individual. …”
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Role of African horsesickness virus protein NS3 in cytotoxicity and virus induced cytopathology

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In silico and in vitro inhibition of α- glucosidase and α-amylase by compounds from culinary herbs and spices, for possible treatment of type 2 diabetes

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Industrial yeast strains engineered for controlled flocculation by Govender, Patrick

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In silico identification and in Vitro assessment of a potential anticancer peptide sequence retrieved from the red sea metagenomics library by Imam, Mona Elradi

“…The peptide showed evident, yet variable, dose dependent cytotoxicity in all tested cell lines. Membranolysis and Apoptosis could be concluded as possible mechanisms of action from the results of annexin assay and RT-PCR that showed overexpression of Caspase 3 in peptide treated U2OS cells. …”
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Evaluating the bioactivity and biocompatibility of nylon coated ultra-high molecular weight polyethylene (UHMWPE) by Hassanein, Nancy

“…The assessment of the U2-OS cell viability using MTT assay has suggested that both materials appear to not cause cell cytotoxicity and may be accelerating the cellular proliferation after 72 hours when compared to the control sample. …”
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Evaluating the predictive performance of cytotoxic T lymphocyte epitope prediction tools using Elispot assay data by Meraba, Rebone Leboreng

“…Computational T-cell epitope prediction tools have been previously devised to predict potential human leukocyte antigen (HLA) binding peptides from protein sequences. …”
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Targeted depletion of RibF, a putative bifunctional FAD synthetase/ flavokinase in Mycobacterium smegmatis using CRISPR interference by Raphela, Mabule Lucas

“…CRISPR interference (CRISPRi) technology was used to generate an anhydrotetracycline (ATc)-inducible ribF hypomorph of M. smegmatis, a widely exploited mycobacterial model. …”
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Diel and seasonal dynamics of Anaulus australis at Muizenberg Beach, South Africa by De Vos, Casha

“…At Muizenberg Beach, the diel cycle persisted even when patches were not visible, with cell concentrations peaking in the morning (mean ± SD: 4.64 ± 6.19x104 cells.mL-1 ) and declining by late afternoon, reaching zero cells.mL-1 by 17:00 at some stations. …”
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Biochemical characterization of the thrombin inhibitor of the tick, Ornithodoros savignyi, and investigation into the expression of its recombinant forms

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Multicellular spheroids as a platform for cytotoxicity assessment of nanoparticles

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