Elucidation of mechanisms of antibiotic subversion in mycobacteria by Naran, Krupa

“…The DNA damage response: the SOS response was hypothesized to play a role in antibiotic- mediated cellular death, and that disabling the mycobacterial SOS response, by generating non-cleavable LexA mutants (lexA Ind-), could be used as a tool to validate antibiotic-mediated cell death. …”
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High-Throughput Determination of Mycobacterium smegmatis Protein Complex Structures by Kirykowicz, Angela Mary

“…The rise of multiand extensively-drug resistant Mycobacterium tuberculosis (Mtb), the causative agent of TB, has led to further developments in understanding the physiology of Mtb during infection, as well as searching for novel drug targets, in order to combat the disease. Our understanding of cells, both eukaryotic and prokaryotic, has changed substantially in the last 50 years, incorporating the role of stable and transient protein-protein interactions which govern cell function and behaviour. …”
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Towards tandem bio-chemo catalytic systems for the activation of alkanes and subsequent oxidation of alcohols to aldehydes using biofabricated Pd and Au catalysts by Govender, Mivashya

“…E. coli BL21DE3 was previously used as the host cell for the biocatalytic activation of alkanes. …”
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A numerical assessment of architectural parameters for anisotropic behavior in idealised trabecular structures by Moore, Keelan

“…Trabecular bone has a complex, heterogeneous, anisotropic open cell lattice structure with a large variation in mechanical properties across anatomic site, species, sex, age, normal loading direction and disease state. …”
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Platinum group metals catalyzed steam methane reforming via micro-channel reactor by Zhou, Yi

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Modified polyethylene glycol hydrogels for growth factor delivery and controlled tissue invasion by Gustafsson, Carla Astrid

“…Sprouting of endothelial cells from PEG hydrogel embedded spheroids was shown to increase as the PEG-AC concentration increased. …”
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Investigating the role of sestrin 1 and sestrin 2 in preclinical models of tuberculosis disease by Naidoo, Saiyukthi

“…The increased inflammation was associated with enhanced total lung and lymph node cells, immune cell recruitment and lung tissue pathology. …”
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Genetic, antigenic and phenotypic comparison of herpesviruses isolated from domestic and wild felids

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Longitudinal transcriptomic profiling of whole blood during tuberculosis treatment by Odia, Trust Osee

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The bioactivity of Fynbos honey compared with Manuka honey in a salt- and enzyme-based synthetic saliva

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Investigating a potential role for ATM protein kinase in the ER stress response in cardiovascular pathology by Bester, Danelle

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The production and purification of functional steroid hormone receptor ligand binding domains towards the development of a biological endocrine disruptor detection system by Tait, Timo

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Disruption of microorganisms due to agitation in slurries of fine particles by Pearce, Sarah Jane Amanda

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The use of the broad-host-range plasmid, pTF-FC2, in Agrobacterium tumefaciens mediated plant transformation by Dube, Thabani

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Investigating the mechanism of action of hormones used in hormone replacement therapy via estrogen receptor subtypes and the influence of the progesterone receptor by Perkins, Meghan Samantha

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Cross species identification of genetic factors that determine fruit surface characteristics by Lashbrooke, Justin Graham

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Reference intervals for haematology, clinical chemistry and acute phase reactants in free-ranging African elephants (Loxodonta africana)

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Toxic mitochondrial effects induced by "red devil" chemotherapy by Opperman, Caleigh Margaret

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Promoting circular economy and sustainable construction practices : investigating the integration of waste upcycling for a greener future, with a focus on eggshell and eggshell mem...

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Development of a process modelling methodology and condition monitoring platform for air-cooled condensers by Haffejee, Rashid Ahmed

“…A utility-scale 64-cell ACC system based in South Africa was selected for this study. …”
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