The three-dimensional kinematics and spatiotemporal parameters of gait in 6-10 year old typically developed children in the Cape Metropole A Pilot Study by Smith, Yvonne

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Development of SNAP-tag based fusion proteins as novel auristatin F-containing immunoconjugates and photoimmunotheranostics in the detection and treatment of triple-negative breast... by Mungra, Neelakshi

“…Based on the above premises, this research aims to use SNAP-tag technology as a cutting-edge site-specific conjugation method to: (1) develop a comprehensive antibody platform, consisting of single-chain antibody fragments (scFvs) genetically fused to SNAP-tag, to specifically screen and evaluate their predictive potential for chondroitin sulfate proteoglycan 4 (CSPG4), CD44 and aspartate (aspartyl/asparaginyl) β-hydroxylase (ASPH)-positive TNBC cells, (2) generate functional recombinant ADC formulations as robust delivery systems carrying the antimitotic drug monomethyl auristatin F (MMAF/AURIF), concurrently overcoming production constraints to yield therapeutically viable and homogeneous combination products, and (3) provide a fail-safe system that overcomes the lack of specificity of photodynamic therapy (PDT), by coupling scFv-SNAP-tag to the potent near-infrared (NIR) photosensitizer (PS) IRDye700DX (IR700) and to demonstrate its selective dose-dependent cytotoxic activities in vitro. …”
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The impact of water pollution from formal and informal urban developments along the Plankenbrug River on water quality and health risk / J.M. Barnes. by Barnes, J. M. (Johanna Maria)

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The role of Pharmacogenomics in the Personalization of Parkinson’s Disease Treatment in Egyptian Regions by William, Martina

“…LRRK2 inhibitors could be promising therapeutic options for this population. Our virtual screening findings highlight the potential for repurposing existing compounds and suggest new therapeutic development avenues targeting the G2019S mutation in LRRK2 in Egypt. …”
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Development and analytical validation of a genus-specific Brucella real-time PCR assay targeting the 16S-23S rDNA internal transcribed spacer

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Functional effects of cytochrome P450 variants on drug metabolism and adverse drug reactions: developing and extending high throughput P450 protein technology platforms by Nair, Omesan

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A study of the impact of salinity on growth and development of important tomato and banana cultivars of the Jordan Valley with an assessment of the efficacy of biostimulants as ame... by Abu Zurayk, Iad

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Formative research for the development of an appropriate, acceptable and feasible intervention aimed at reducing type 2 diabetes risk in disadvantaged women after gestational diabe... by Muhwava, Lorrein Shamiso

“…This thesis constitutes the formative research for a complex intervention study aimed at developing and evaluating a novel health system intervention to reduce the subsequent risk of developing type 2 diabetes among women with GDM. …”
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Examining the representation of asexuality in select examples of visual culture

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Maternal mental health : a prospective longitudinal cohort study of the outcome of planned versus unplanned pregnancy in women with major psychiatric disorders in a developing coun... by Du Toit, Elizabeth

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Development of a cost-effective system for ovoviviparous production of Artemia nauplii at low-salinity as live food for the larvae of the African catfish (Clarias gariepinus: Burch... by Bwala, Richard

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The epidemiology of non-traumatic injuries in road cyclists participating in the Cape Town tour

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Repositioning the antitubercular candidate SQ109 as potent antimalarial with polypharmacology

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The identification of ligands of cardiac Connexin 45 (Cx45) and their possible association with the development of the cardiac conduction disorder, Progressive Familial Heart Block... by Nxumalo, Nqobile

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Host genetics and haemoparasite diversity in the common warthog (Phacochoerus africanus) from South Africa

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Optimisation of retention of Mangiferin in Cyclopia Subternata during preparation for drying and storage of green honeybush and development of Nir Spectroscopy Calibration models f... by Maicu, Maria Christina

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Problematic feeding behaviours in infants and the mental health of their caregivers : a descriptive study at two public health care facilities in the Western Cape by Subramoney, Jeannine

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Exploring high school teachers understanding and implementation of the SIAS policy in a mainstream school by Melane, Judith

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Anti-ferroptotic properties of isolates from traditional South African medicinal plants in a 6-hydroxydopamine-induced SH-SY5Y cytotoxicity model

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