Investigating the immune modulatory properties of kisspeptin: implications for pregnancy by Botha, Stefan Marc

“…To test this hypothesis, we used a previously established in vitro peripheral blood mononuclear cell (PBMC) Mycobacterium tuberculosis (Mtb) infection assay model as well as a newly established in vitro infection model using lipopolysaccharide (LPS)-stimulated whole blood. Protein expression analysis of selected pro- and anti-inflammatory cytokines was performed on PBMC infected with Mtb and on whole blood cells stimulated with LPS in the absence and presence of kisspeptin-10 for different times. …”
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Modelling the early development of cartilage and bone in Mseleni Joint Disease using induced pluripotent stem cells by Mkatazo, Thulisa

“…Changes in the morphology, growth characteristics and expression of relevant CD markers were determined. The mesenchymal phenotype was confirmed by the positive qRT-PCR expression of CD73, 105 and 90. …”
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Effect of an obesogenic diet on the epigenetic profile of livers from Wistar rats and treatment with an aspalathin-rich rooibos extract by Abrahams, Yoonus

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Development and characterisation of recombinant LSDV-vectored dual vaccines against bovine leukaemia virus and lumpy skin disease virus by Suzuki, Akiko

“…Furthermore, BLV Env and Gag protein expression were confirmed by immunofluorescent staining and Western blotting, respectively. …”
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High-content and super-resolution microscopy reveals the dynamic nuclear architecture and mobile epigenetic marks in Plasmodium falciparum

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Investigating the functionality of candidate susceptibility genes in ophthalmoplegic myasthenia gravis using patient-derived material by Moyakhe, Lihle Bayavuya

“…There was no difference in TGFB1 expression levels between OP- MG and control ocular fibroblasts under basal conditions or following treatment with MG sera (p>0.3). …”
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Characterization of signalling cross-talk between the EP2 and FP receptors in endometrial epithelial cells by Abera, Aron Berhanie

“…The EP3 receptor has a protective role in tumor development suggesting the role for down-regulation of the receptor in uterine fibroids pathology. In addition, the expression of COX enzymes, prostaglandin receptors and prostaglandin-mediated genes were assessed in endometrium samples from women with and without uterine fibroids in different stages of the menstrual cycle. …”
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Investigating the effect of Staphylococcus epidermidis on the growth dynamics of Staphylococcus aureus in atopic dermatitis by Moonsamy, Rasalika Tamika

“…The majority (70%) of established biofilms were composed of a proteinaceous matrix. Expression of esp was detected in 63% of S. epidermidis isolates. …”
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Co-operative governance in the national and provincial departments of education in South Africa

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Investigating the role of inflammation, progestins and steroid receptors in breast cancer by Eksteen, Anishka

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In vitro validation of chemo-transcriptomic fingerprints for the classification of the mode of action of antimalarial drugs

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Characterizing various aspects of the male genital tract barrier function and immunity by Rametse, Cosnet

“…This PhD thesis examines barrier function, the density of HIV target cells and various expressed epithelial barrier proteins and genes in different anatomical sites of the intact penis before VMMC and in foreskin tissue after surgical removal. …”
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Elucidation of Diuraphis noxia biotype-specific responses in Triticum aestivum (98M370 Dn7+)

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Efficacy and mechanistic study of a carbohydrate derived fulvic acid with anti-inflammatory properties

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Urban Soundscape: Music centre in Langa by Mahlangu, Nkosinathi Ernest

“…This dissertation is borne out of an interest I have in music as an expression of culture and being, its influence on social spaces and its effectiveness as a tool that transcends across cultures. …”
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Investigation of neuron T cell interaction in central nervous system tuberculosis by Choshi, Phuti Sophia

“…In co-cultures, neurons induced expression of Tbet, RorγT and Gata3 T cell transcription factors through direct contact with T cells. …”
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Sound emanating from the Self : an investigation of the role sound and music in the healing of disturbed Self states by Anderson, Helen Elizabeth

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Novel hypothalamic G protein-coupled receptors involved in the control of reproduction

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Improvement of the Capripoxvirus, lumpy skin disease virus for use as a vaccine vector by Munyanduki, Henry Munyaradzi

“…Transcriptome analysis of messenger RNA from spleens of mice infected with nLSDV or Herbivac for 24hrs was carried out to determine the effect of Herbivac or nLSDV infection on host gene expression. Compared to the PBS control, nLSDV and Herbivac induced the differential expression of 98 genes in common, largely related to response to viral infection. nLSDV differed in the unique expression of 6 genes and Herbivac differed in the unique expression of 36 genes, including granzyme A and Poly (ADP-ribose) polymerase (Parp 9). …”
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