Full Text Available
Access Repository
Search Results - findings agent
- Go to Previous Page
- Showing 41 - 41 results of 41
-
STUDIES ON THE ASCARIS-BACTERIA RELATIONSHIP IN MAN AND PIGLETS
Published 1983-11Call Number: Loading…
Located: Loading…Thesis Loading…
Search Tools:
Refine Results
Page will reload when a filter is selected or excluded.- Aflatoxin B1 5 results 5
- Chromolena odorata 5 results 5
- Gut 5 results 5
- Inflammation 5 results 5
- Liver 5 results 5
- Melatonin 5 results 5
- Aflatoxins are known to produce chronic carcinogenic, mutagenic, and teratogenic effects, as well as acute inflammatory effects, especially in the gastrointestinal tract. The potentials of the flavonoid-rich extract from Chromolena odorata (FCO) and melatonin (a standard anti-oxidant and anti-inflammatory agent) against aflatoxin B1 (AFB1)-induced alterations in pro-inflammatory cytokine levels and morphology of liver and small intestines were evaluated in this study. We utilized Wistar albino rats (200–230 g) randomly divided into five groups made up of group A, control rats; group B, rats given AFB1 (2.5 mg/kg, intraperitone al) twice on days 5 and 7; rats in groups C, D, and E were treated with melatonin (10 mg/kg, intraperitoneal) or oral doses of FCO1 (50 mg/kg) and FCO2 (100 mg/kg) for 7 days, respectively, along with AFB1 injection on days 5 and 7. Serum levels of interleukin 1 beta (IL-1β) and tumor necrosis factor alpha (TNF-α) were determined using commercial ELISA kits and histopathological evaluation of the liver, duodenum, and ileum were also carried out. We observed significant elevation (p < 0.05) in serum IL-1β correlating with hemorrhages and leucocytic and lymphocytic infiltration in the liver and intestines as evidences of an acute inflammatory response to AFB1 administration. All treatments yielded significant reduction (p < 0.05) in IL-1β levels, although TNF-α levels were not significantly altered in all rats that received AFB1, irrespective of the treatments. Melatonin and FCO2 produced considerable protection of hepatic tissues, although melatonin was not quite effective in protecting the intestinal lesions. Our findings suggest a modulation of cytokine expression that may, in part, be responsible for the abilities of C. odorata or melatonin in amelioration of hepatic and intestinal lesions associated with aflatoxin B1 injury. 4 results 4
- Absence of acquisition of vocational skills on the part of the youths has been considered the bane of the economy of many African societies, particularly Nigeria. The National Directorate of Employment (NDE) schemes were the intervention strategies introduced by the government in its frantic effort to find a lasting solution to youth unemployment. In the light of the above, the study looked at the NDE schemes as a source of provider of employment through youth empowerment schemes in Oyo State, Nigeria. The descriptive research design of the expost-facto type was adopted for the study. The population for the study comprised all the youths who have benefited from the vocational skill acquisition and small scale enterprise schemes of the NDE in Oyo State, Nigeria. Random sampling technique was used to select 450 youths who benefited from the vocational skill acquisition scheme and the small scale enterprise schemes of the NDE. The instrument used was a questionnaire tagged "Skill Acquisition and Youth Empowerment Questionnaire" (SAYEQ) with four sub-sections. Two hypotheses were tested at 0.05 level of significance and the finding showed that there is significant impact of NDE vocational skill acquisition training scheme on youth empowerment (F(l.398) = 46. 769; P,<.05); there is significant impact of NDE small scale enterprises scheme on youth empowerment (F(l.398) = 99.284; P, <.05). It is recommended that industrial social worker should sensitise the government as to how best they can use these programmes (VSS and SSE) as agents of change in the life, socialisation and economic empowerment of youths within their communities and the nation at large. 3 results 3
- Nigeria 3 results 3
- Apprenticeship 2 results 2
- Citizenship transformation 2 results 2
- Economy 2 results 2
- Engineering & Technology 2 results 2
- Labour 2 results 2
- National directorate of employment 2 results 2
- Pedagogical tool 2 results 2
- Positive change 2 results 2
- Productivity 2 results 2
- Social Studies 2 results 2
- Social Studies is a subject designed for knowledge, skills and values acquisition to transform citizens to become agents of change in their immediate and global environment. This study investigated teachers’ perception of Social Studies as a pedagogical tool for Citizenship transformation and positive change in new Nigeria. It was guided by three hypotheses. Descriptive survey design was adopted for the study. The population consisted of 166 Social Studies teachers from 47 public secondary schools in Ogbomoso. A total of 118 Social Studies teachers was sampled using purposive sampling technique. Teachers’ Perception of Social Studies Curriculum Questionnaire (TPSSCQ) with reliability coefficient of 0.98 was used for data collection. Percentage and Independent t- test was used to analyze the data at 0.05 level of significance. Findings from the study revealed that Social Studies curriculum content is a pedagogical tool suitable for citizenship transformation and positive change in new Nigeria. Based on these findings it was recommended that, Social Studies teachers in secondary schools should be sensitized on how to transform citizens through Social Studies contents to become agents of positive change in Nigeria. 2 results 2
- antioxidant 2 results 2
- cyclophosphamide 2 results 2
- gallic acid 2 results 2
- neurotoxicity 2 results 2
- oxidative stress 2 results 2
- "Hepatitis E virus (HEV) infection is both a major public health concern and emerging global health concern, with a documented incidence of 20 million, 3.4 million clinical cases, 70,000 deaths, and 3,000 stillbirths. The aetiologic agent, HEV is a primarily enterally transmitted hepatotropic virus. Fecal samples were collected from three selected pig farms across Ibadan, South-west Nigeria. Randomly picked samples were pooled per unit pen and fecal suspensions prepared were subjected to HEV Antigen (Ag) enzyme-linked immunosorbent assay. Molecular probing was done by Reverse Transcription and nested polymerase reaction (RT-nPCR) and deep sequencing. Sequencing was done paired-end for 300 cycles using the HiSeq system. Overall farm prevalence of 66.7% (2/3) and prevalence at individual level of 13.2% (9/68) were recorded. All nine samples positive for the ELISA screen were negative when subjected to RT-nPCR assays. Further, on deep sequencing, no HEV genomic fragment was found in the sample using de-novo assembly. Findings suggest possibly inapparent HEV in the pigs studied or a yet to be identified protein with HEV-Ag cross-reactivity ability on ELISA, thus constituting a possible risk of exposure to HEV infection in the population. Consequently, we recommend prompt intervention to unravel the mystery and break the chain of transmission. 1 results 1
- "Using a qualitative method, this paper analyses the institutions in Nigeria’s livestock trade which enable an understanding of the actors and the nature of their interactions in the transportation of cattle from centres of production to the final consumers, using the Bodija cattle market in lbadan as the case study. This paper is viewed within Alonso’s General Theory of Movement, and by extension, Ullman’s bases of spatial interaction. Fixed routes are followed in a north-south direction, with extraneous time consuming and quite often risky overland doverage of the earliest stages o f movement, through railway carriage, though not without hitches. There road transport has dominated the movement of cattle in Nigeria, often by the private sector, not without its attendant problems though. Information was collected from leaders in cattle marketing and transportation, noting especially the ethnicity and gender relations. The data collection involved group interview, direct observations and extraction of relevant information from published sources. The findings show that formal and informal actors are involved in cattle transportation business. The movement of cattle to Akinyele was from the northern states. The choice of the marker by cattle dealers largely depends on prices at various source markets, easy availability of transport, and varieties of cattle species in demand. The availability of mobile phones has facilitated the exchange of information. Transportation is largely arranged through Yan Kwammssion (commissioned agents), and transport costs vary in proportion to the distance travelled." 1 results 1
- 1. Introduction Primary thalamic tumours are rare [1]. They account for 1–1.5% of all brain tumours and approximately a quarter of them occur in children younger than 15 years [2,3]. Bilateral thalamic gliomas (BTGs) are extremely rare sub-types of thalamic tumours, which are known to have a poor outcome regardless of the treatment modality [4]. About 70 cases have been reported so far in the literature [5]. We present the outcome of treatment of BTG in a three-year-old Nigerian child and a brief review of the literature on these uncommon types of central nervous system tumours. 2. Case Presentation A three-year-old right-handed boy presented with headache, abnormal gait, and inability to sit unsupported of one week duration. There was an associated history of drowsiness, excessive sleeping, and multiple episodes of projectile vomiting. Examination revealed a young boy who was fully conscious but drowsy. His pupils were of normal size but reacted sluggishly to light. He had bilateral abducens nerve palsies, bilateral papilloedema, global hypertonia/hyperreflexia, and bilateral extensor plantar responses. He also had truncal ataxia and dysmetria but no sensorimotor deficit. Examination of other systems revealed normal findings. A clinical diagnosis of acute onset raised intracranial pressure from an infratentorial space-occupying lesion was made. Cranial computed tomography scan showed bilateral symmetrical enlarged thalamic nuclei which were hypodense to isodense and non-contrast enhancing (Fig. 1a and b). There was associated obstructive hydrocephalus. Brain magnetic resonance imaging showed bilateral symmetrical non-enhancing masses involving both thalami (with estimated volumes of 40.17 cm³ on the right and 44.84 cm³ on the left). These were hypointense on T1-weighted images and hyperintense on T2-weighted and FLAIR images. There was associated dilatation of the lateral ventricles and effacement of the quadrigeminal/ambient cisterns bilaterally (Fig. 2a–d). A radiological diagnosis of a bilateral thalamic tumour was made. The patient's management was multidisciplinary, involving the neurological surgery, radiology, pathology, paediatric oncology, and radiation oncology teams. A biopsy specimen obtained via an endoscopic transventricular route showed features of a WHO grade II diffuse astrocytoma (Fig. 3a–c). He subsequently received sixteen courses of Vincristine/Carboplatin chemotherapy, which was later changed to Etoposide/Cisplatin on account of clinico-radiological evidence of tumour progression. He had cerebrospinal fluid diversion (via a ventriculoperitoneal shunt) five months after the initial procedure due to worsening hydrocephalus (Fig. 4a–c). The second-line chemotherapeutic agents were discontinued after the third cycle on request by the patient's mother because of their side effects (bone marrow suppression, widespread dermatitis, recurrent chest infection). Radiotherapy was considered unsafe in this patient given his age and the potential for radiation-induced neurocognitive decline (on the advice of the radiation oncology team). Repeat neuroimaging at six months following the initial surgery showed further tumour progression with involvement of the caudate nuclei and brainstem, and extension into the lateral ventricles (Fig. 5a–c). Attempts at switching his chemotherapeutic agents were futile due to non-availability of the drugs. At nine months post tumour biopsy, he had recurrent headache and vomiting, expressive aphasia, worsening gait imbalance, ataxia, paraparesis, bilateral ptosis, upgaze paresis, and choreoform movements. He subsequently defaulted follow-up. 1 results 1
- ACT 1 results 1
- Accidents 1 results 1
- see all…