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Intermittent explosive disorder subtypes in the general population: association with comorbidity, impairment and suicidality
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A statistical approach to estimate wind speed distribution in ibadan, nigeria
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Post-traumatic stress disorder among recently diagnosed patients with HIV/AIDS in South Africa
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HEALTH RELATED QUALITY OF LIFE OF STUDENTS WITH PHYSICAL AND SENSORY IMPAIRMENTS IN SPECIAL AND INTEGRATED SCHOOLS IN IBADAN.
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Association between depression and hypertension in the Ibadan Study of Ageing. African
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COVID-19 in Nigeria: Is the pharmaceutical sector spared?
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Page will reload when a filter is selected or excluded.- Depression 2 results 2
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- "Background—Chronic pain is quite common in the elderly and is often associated with co morbid depression, limitation of functioning and reduced quality of life. The aim of this study was to ascertain whether there is a differential risk of depression among persons with pain in different anatomical sites and to determine which pain conditions are independent risk factors for depression. Methods—Data is from the Ibadan Study of Ageing (ISA), a community based longitudinal survey of persons aged 65 years and older from eight contiguous Yoruba Speaking states in Nigeria (n = 2152). Data was collected in face-to-face interviews; depression was assessed using the World Mental Health initiative version of the Composite International Diagnostic Interview (CIDI) while chronic pain was assessed by self-report (response rate = 74%). Results—Estimates of persistent pain (lasting more than 6 months), in different anatomical sites range from 1.3% to 12.8%, with the commonest being joint pains (12.8%), neck or back (spinal) pain (7.6%) and chest pain (3.0%). Significantly more pain conditions were reported by females and by respondents who were aged over 80 years. The risk for depression was higher in respondents with spinal, joint and chest pain. However, only chest pain was independently associated with depression after adjustments were made for pains at other sites and for functional disability. Conclusion—Our data suggests that, among elderly persons, there is a differential association of depression with chronic pain that is related to the anatomical site of the pain." 1 results 1
- "This study examines how federal restructuring and decentralisation can be tailored towards the creation of an enabling environment for business in Nigeria. It does this by making a comparative assessment of the business environment in Nigetia; exploring the character of federalism and decentralisation programmes in Nigeria. It also examines the implications of these for governance and the business environment in Nigeria while suggesting decentralisation reforms required to enhance government efficiency and effectiveness as well as improving the business environment. The study noted that decentralization programmes in Nigeria began from the colonial era but have largely taken the form of spatial deconcentration. As a result, they have had the effect of increasing central control and reducing opportunities for citizen participation, and stultified creativity. The restraint in devolving power is attributable to the effort at regime sustenance in the face of limited state legitimacy, the problem of fragile national unity and the prevalence of military dictatorship with its centralizing tendencies. Territorial fragmentation and internal boundary adjustments have resulted in a proliferation of states and local governments; but such levels of government have been without local power that can attract and stimulate participation. Spatial deconcentration has resulted in a bloated states sector, with minimal private sector development, and a suppression of innovative and entrepreneurial energy. Dependence of sub-national units on oil revenue from the centre has been one of the major reasons fur the failure to diversify the economic base of the country. The competition that had characterised inter-state relations under the three and four-region Systems in which derivation was a significant factor of horizontal revenue sharing gave way to political struggles for federation funds. Thus, local spending became completely separated from local resources in the name of even development across the country. The centralisation of resources control and the adoption of a general revenue allocation formula provided no incentive for competitiveness among the various sub-national governments. Decentralisation reforms have become imperative but need to be done democratically. There should be wide spread consultation and negotiation to reach consensus on an ideological base for the envisaged decentralization programme. There should also be very clear institutional arrangement for managing the process, realistic and clear-cut distribution of powers and functions among the various governments based on the principle of subsidiarity with clearly spelt out institutions of horizontal and vertical accountability. The programme should be informed by a more practicalconcern about economic competitiveness, such that the country will be restructured into competing governmental units, providing room for public/private partnership in productive activities at the lower levels, such that would enable the exploration and development of economic potentials of the various states. The current general revenue sharing formula should be reconsidered with a view to promoting competition hand in hand with the drive for equity and accountability. Caution should be taken during the process to avoid fanning the embers of centrifugal forces. Nigeria should borrow ideas from successful decentralisation efforts in other lands. " 1 results 1
- 21st Century Library 1 results 1
- Academic Libraries 1 results 1
- Actor-merchants 1 results 1
- Adolescents 1 results 1
- Africa 1 results 1
- Agricultural Transformation (AT) requires a new and different approach to policy making and implementation. It entails search by government for greater integration and co-ordination, looks for an approach that is characterized by greater partnership between federal, state and local government, economic entities, private industry and other community groups. The process involves diversification in the sector to meet changing domestic and trade demands. This study was mainly contents review of relevant literature and use of situation analysis. We examined agricultural policies changes in Nigeria and draw some lessons from successful agriculturally transformed countries. The results show that, bypassing small farmers during the process of AT is capable of marginalizing a large group of the rural population and cause social tensions. AT requires a comprehensive long term strategy that needs to be supported by long term commitment from the government and international development partners. The various steps Nigeria had taken in its AT process are necessary but not sufficient conditions for a successful transformation. Successful AT must be broad-based with efficient infrastructural investments in roads network, irrigation, consistent energy supply, high-speed and affordable communications, clear and consistent long-term policies, good working relationship among ministries and governmental bodies, effective rule of law, and good adaptation and mitigation measures consistent with sustainable development. 1 results 1
- Aims. Intermittent explosive disorder (IED) is characterised by impulsive anger attacks that vary greatly across individuals in severity and consequence. Understanding IED subtypes has been limited by lack of large, general population datasets including assessment of IED. Using the 17-country World Mental Health surveys dataset, this study examined whether behavioural subtypes of IED are associated with differing patterns of comorbidity, suicidality and functional impairment. Methods. IED was assessed using the Composite International Diagnostic Interview in the World Mental Health surveys (n = 45 266). Five behavioural subtypes were created based on type of anger attack. Logistic regression assessed association of these subtypes with lifetime comorbidity, lifetime suicidality and 12-month functional impairment. Results. The lifetime prevalence of IED in all countries was 0.8% (S.E.: 0.0). The two subtypes involving anger attacks that harmed people (‘hurt people only’ and ‘destroy property and hurt people’), collectively comprising 73% of those with IED, were characterised by high rates of externalising comorbid disorders. The remaining three subtypes involving anger attacks that destroyed property only, destroyed property and threatened people, and threatened people only, were characterized by higher rates of internalising than externalising comorbid disorders. Suicidal behaviour did not vary across the five behavioural subtypes but was higher among those with (v. those without) comorbid disorders, and among those who perpetrated more violent assaults. Conclusions. The most common IED behavioural subtypes in these general population samples are associated with high rates of externalising disorders. This contrasts with the findings from clinical studies of IED, which observe a preponderance of internalising disorder comorbidity. This disparity in findings across population and clinical studies, together with the marked heterogeneity that characterizes the diagnostic entity of IED, suggests that it is a disorder that requires much greater research. 1 results 1
- Airport safety 1 results 1
- Airports require complete safety initiatives with a maximum of 20 minutes response time to distress situation. They are therefore regulated by International Civil Aviation Organisation (ICAO) standards. However, in Nigeria, airport safety and distress response have been of great concern due to inadequate infrastructure. This study, therefore, examined safety facilities and response capability to distress situations in Nigeria international airports. The effects of haphazard spatial developments within the airports and their environments were also examined. The available infrastructure for safety and distress response initiatives were considered using ICAO check-list to determine their adequacy. Four international airports namely: Murtala Muhammed (Lagos), Aminu Kano (Kano), Nnamdi Azikwe (Abuja), and Port Harcourt were purposively selected. Three questionnaires were administered to 618 airport operators, 369 users and 462 neighbours in soliciting information on various aspects of safety and distress response initiatives including terminal buildings, navigational aids, runways and fire-fighting equipment and adequacy of staff training for operating Safety Management Systems (SMS) effectively. This was complemented with Key Informant Interview (KII) with 12 technical staff from 5 airport operators. Satellite imagery data were used to acquire spatial information on the airports. Descriptive statistics were used to analyse data on adequacy of safety facilities, staff training and distress responsiveness. Pearson correlation was used to determine the relationship between safety infrastructure and airport age. Analysis of Variance was used to determine variations in airport operators‘ safety awareness as recommended by ICAO. The KII data were content analysed, while raster model was used to determine the landuse pattern. Analysis were done at p<0.05. Functionality of safety facilities fell short of ICAO standards in all the airports by 30%, 25%, 20% and 10% in Lagos, Kano, Port-Harcourt and Abuja respectively. A positive relationship existed between airport age and obsolescence of safety infrastructure (r=0.12). Lagos airport had the most obsolete safety facilities. KII also revealed breakdown of infrastructure in the airports. There were significant variations in safety awareness among airport operators (F=11.95). Safety awareness was highest among the staff of Federal Airports Authority of Nigeria (34.9%) and lowest among airport handling agents (12.2%). Ninety-one percent of airport operators sampled indicated distress response as being poor. Response time varied from 30 minutes in Abuja to 54 minutes in Lagos. Sixty percent of the users considered airport service quality as very low. Forty-six percent of airport operators indicated that they had no training since employed. Spatial analysis of the airports and their environment showed that Lagos and Kano airports suffered safety threats from poor waste management and chaotic traffic patterns. Safety and distress response capacity was relatively low in all the international airports investigated. There is an urgent need for the airports to be managed in line with international standards. Staff training should also be prioritised and spatial developments around airport s need to be controlled. Keywords: Airport safety, Distress response, Spatial development, Civil aviation standards, Nigerian international airports. Word Count: 463 1 results 1
- Anambra state 1 results 1
- Area Coordinates 1 results 1
- Background: A number of empirical relationships have been proposed to describe the compaction of pharmaceutical materials, among them are the Heckel, Kawakita and Gurnham equations. Objective: To characterize the compressibility of fonio, sweet potato and corn starches and their paracetamol formulations using the Gurnham and Kawakita equations, and to determine the complementarity of these equations. Materials and Methods: Starches were extracted from fonio (Digitaria exilis) grains and sweet potato (Ipomea batatas) tubers and modified by acid hydrolysis for 96 h. Paracetamol formulations containing 2.5–10.0 %w/w starch binders were prepared by wet granulation. Packing and compaction properties of native and modified starches and their formulations were determined using tapping procedures. The data obtained was analyzed using the Gurnham and Kawakita equations. Results: The ranking for Gurnham compressibility, c, for the starches was sweet potatocornfonio, which was inversely related to the ranking for Kawakita maximum volume reduction, a and angle of internal flow, θ. There was no clear-cut pattern in the Gurnham compressibility of paracetamol formulation probably due to its multicomponent nature. There was correlation between c, a and θ for all the starches with the modified starches exhibiting higher compressibility than native starches. There appeared to be no correlation between c and Kawakita compressibility index, b. Conclusion: The Gurnham equation appeared useful in characterising compressibility in single component systems and could be used along with Kawakita functions, to gain a better understanding of the deformation of powdered materials under pressure. 1 results 1
- Background: Childhood and adolescent depression is common and often persists into adulthood with negative implications for school performances, peer relationship and behavioural functioning. The Child Depression Inventory (CDI) has been used to assess depression among adolescents in many countries including Nigeria but it is uncertain if the theoretical structure of CDI appropriately fits the experiences of adolescents in Nigeria. This study assessed varying theoretical modelling structure of the CDI in a population of apparently healthy adolescents in Benue state, Nigeria Methods: Data was extracted on CDI scale and demographic information from a total of 1, 963 adolescents (aged 10–19 years), who participated in a state wide study assessing adolescent psychosocial functioning. In addition to descriptive statistics and reliability tests, Exploratory Factor Analysis (EFA) and Confirmatory Factor analysis (CFA) were used to model the underlying factor structure and its adequacy. The suggested new model was compared with existing CDI models as well as the CDI’s original theoretical model. A model is considered better, if it has minimum Root Mean Square Error of Approximation (RMSEA <0.05), Minimum value of Discrepancy (CMNI/DF<3.0) and Alkalike information criteria. All analyses were performed at 95% confidence level , using the version 21 of AMOS and the R software. Results :Participants were 14.7±2.1 years and mostly male (54.3%), from Monogamous homes (67.9%) and lived in urban areas (52.2%). The measure of the overall internal consistency of the 2-factor CDI was α = 0.84. The 2-factor model had the minimum RMSEA (0.044), CMIN/DF (2.87) and least AIC (1037.996) compared to the other five CDI models. Conclusion: The child depression inventory has a 2-factor structure in a non-clinical general population of adolescents in Nigeria. Future use of the CDI in related setting may consider the 2-factor model. 1 results 1
- Background: Pituitary and gonadal dysfunctions resulting from increased adiposity leading to disturbances of sexual and reproductive functions have been reported in males with metabolic syndrome (MS) and type 2 diabetes mellitus (DM2). The aim of this study was to evaluate sexual dysfunction, leptin, and reproductive hormones in Nigerian males with MS and DM2. Methods: Participants were 104 men (34 males with DM2, 17 men with MS and 53 men with normal body mass index (18.5-24.9 Kg/m2) without MS (controls)). The International Diabetes Federation (2005) criteria were used for MS diagnosis. Reproductive history, anthropometry, blood pressure (BP) and 10 ml fasting blood samples were obtained by standard methods. Fasting plasma glucose, total cholesterol, triglycerides and high density lipoprotein cholesterol were determined by enzymatic methods while low density lipoprotein cholesterol was calculated. Leptin, follicle stimulating hormone (FSH), luteinising hormone (LH), prolactin, testosterone and oestrogen were determined by enzyme immunoassay (leptin by Diagnostic Automation, Inc.; others by Immunometrics (UK) Ltd.) while oestrogen-testosterone ratio was calculated. Data analyzed using ANOVA, Chi square and multiple regression were statistically significant at p<0.05. Results: Testosterone was significantly lower in MS than controls while oestradiol and ETR were significantly higher in MS compared with controls and DM2 group (p<0.05). ETR significantly predicted testosterone in all groups (p<0.05). Significantly lower libido was observed in men in MS than controls and DM2 groups (p<0.05). Conclusion: Sexual and reproductive dysfunction may be related to increased conversion of testosterone to oestrogen in increased adipose mass in men with metabolic syndrome and type 2 diabetes mellitus. 1 results 1
- Background: Psychiatric disorders in HIV/AIDS are common, emerging soon after diagnosis or during the subsequent course of illness. However, there are few prospective studies on the rates of psychiatric disorders in HIV/AIDS, particularly in the context of the developing world. Methods: Sixty-five patients with recently diagnosed HIV were interviewed on presentation to a hospital-based HIV clinic and then 6 months later. On both interviews, the patients were assessed using the MINI International Neuropsychiatric Interview, the Carver Brief COPE, and the Sheehan Disability Scale. Exposure to negative life events and risk behaviors was also evaluated. Results: The overall prevalence of psychiatric disorders in the follow-up period remained high (56% of patients had at least one psychiatric disorder at baseline, and 48% of patients had at least one psychiatric disorder at 6 months). Depression and posttraumatic stress disorder (PTSD) were the most prevalent disorders at both baseline (34.9% and 14.8%) and follow-up (26% and 20%), respectively. More than half of all patients with depression at baseline improved (16 of 29; 55.1%). However, there was a new onset of both depression (4 of 49; 8.1%) and PTSD (12 of 17; 70.5%) on follow-up. In univariate analysis, depression on follow-up was significantly associated with: (a) disability in work/social/family functioning, (b) greater number of negative life events, and (c) a decline in CD4 lymphocyte count. Univariate analysis also revealed that a diagnosis of PTSD on follow-up was significantly associated with (a) a longer duration of infection and (b) baseline disability in work/social/family functioning. However, in multivariate analysis, only disability scores predicted the diagnoses of major depression and PTSD on follow-up assessment. Persistence of risky sexual behaviour was also noted, with a significantly higher number of participants reporting nonuse of condom on follow-up. There appeared to be a shift from maladaptive coping behaviors to more adaptive coping behaviors over the 6-month period. Conclusion: The rate of psychiatric disorders in HIV/AIDS patients was consistent over time. These findings emphasize the importance of regular evaluation for psychiatric disorders in HIV/AIDS patients, not only at the commencement of treatment but also during subsequent follow-up visits. 1 results 1
- Background: Sexual dysfunction is more common among patients with mental disorders compared to the general population. Despite this high occurrence, information regarding sexual dysfunction as well as their correlates in patients receiving care for mental disorders in developing countries is still sparse. Aim: To determine the prevalence and correlates of sexual dysfunction among patients with mental disorders receiving care in a tertiary hospital in Southwest Nigeria. Setting: This study was performed at the psychiatric outpatient clinic at the University College Hospital, Ibadan, Southwest Nigeria. Methods: A cross-sectional study was conducted on a convenience sample of 238 adults aged 18–60 years. Socio-demographic and clinical information was obtained from all recruited patients. Sexual dysfunction was assessed using the International Index of Erectile Function questionnaire for men and the Female Sexual Function Index questionnaire for women. Questionnaires for measuring depression, medication adherence and autonomic medication side effects were also administered. Associations between sexual dysfunction and socio-demographic and clinical factors were explored. Results: The prevalence rates of sexual dysfunction among male and female participants were 84.7% and 95.7%, respectively. In the multivariate analysis, employment status and autonomic side effects of psychotropic medications significantly predicted male sexual dysfunction, while religion and employment status were predictors of female sexual dysfunction. Conclusion: Sexual dysfunction is very common among patients with mental disorders, with higher rates in female participants. There is a need for clinicians to consider routine screening for sexual dysfunction in psychiatric outpatients with a view of providing psychosocial interventions to improve patient’s quality of life. 1 results 1
- Background: The aim of the current study was to explore the changing interrelationships among clinical variables through the stages of schizophrenia in order to assemble a comprehensive and meaningful disease model. Methods: Twenty-nine centers from 25 countries participated and included 2358 patients aged 37.21 11.87 years with schizophrenia. Multiple linear regression analysis and visual inspection of plots were performed. Results: The results suggest that with progression stages, there are changing correlations among Positive and Negative Syndrome Scale factors at each stage and each factor correlates with all the others in that particular stage, in which this factor is dominant. This internal structure further supports the validity of an already proposed four stages model, with positive symptoms dominating the first stage, excitement/hostility the second, depression the third, and neurocognitive decline the last stage. Conclusions: The current study investigated the mental organization and functioning in patients with schizophrenia in relation to different stages of illness progression. It revealed two distinct “cores” of schizophrenia, the “Positive” and the “Negative,” while neurocognitive decline escalates during the later stages. Future research should focus on the therapeutic implications of such a model. Stopping the progress of the illness could demand to stop the succession of stages. This could be achieved not only by both halting the triggering effect of positive and negative symptoms, but also by stopping the sensitization effect on the neural pathways responsible for the development of hostility, excitement, anxiety, and depression as well as the deleterious effect on neural networks responsible for neurocognition. 1 results 1
- COVID-19 1 results 1
- COVID-19 pandemic 1 results 1
- Cardiovascular disease 1 results 1
- Chronic pain 1 results 1
- Civil aviation 1 results 1
- Classical 1 results 1
- Community pharmacy 1 results 1
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