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The role of steroidogenic factor-1 (SF-1) in gonadotropin-releasing hormone (GnRH) receptor gene regulation
Published 2018“…DNasel footprinting reveals that the major DNA-binding activity in αT3-1 cells on the GnRHR promoter occurs at the SF-1-like site. The SF-1-like sequence specificity of the interaction is demonstrated by gel redardation and DNasel footprinting assays using specific and mutated oligonucleotides as competitors. …”
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In vitro modelling of cellular haemozoin and inhibition by β-haematin inhibitors and their derivatives
Published 2021“…Further investigations into the exchangeable haem amounts as a function of intracellular test compound amounts at the IC50 values of these β-haematin inhibitors highlighted that there was an apparent 1:1 relationship with the amount of intracellular exchangeable haem, indicative of complex formation. …”
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Artificial neural networks and the cross-section of equity returns: identifying nonlinear opportunities on the Johannesburg Stock Exchange
Published 2026“…The optimal neural network architecture is explored, considering varying model depths and node counts. The activation function, training algorithm, learning rate, number of epochs, batch size, and loss function are kept constant across architectures. …”
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Investigating the effects of enhanced catecholamine stimulation in stem cell-derived cardiomyocytes
Published 2026“…A model of sympathetic overdrive was induced by treating the EBs with a synthetic catecholamine, isoprenaline (10μM isoprenaline for 72 hours) as was determined by the results of a preliminary dose-response test. The EB growth patterns were monitored using light microscopy and the images were analysed with ImageJ software. …”
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Cystic fibrosis in South Africa: spectrum of disease, diagnosis, and determinants of outcome
Published 2024“…Implications and novelty of this research are that existing reference ranges for this test may not be applicable in children, and confirmation that the β-adrenergic sweat test is a viable alternative for measuring CFTR function. …”
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Essays on political economy using dynamic general equilibrium models
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Autism Spectrum Disorder and Mitochondrial Dysfunction: The Role of Mitochondrial Dynamics
Published 2023“…Significance for all experiments was determined using unpaired t-tests, one-way ANOVA and correlation analysis (p< 0.05). …”
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Die invloed van versteurde inlaatvloeipatrone op aksiaalwaaiers
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Translation and adaptation of the multilingual assessment instrument for narratives into isiZulu
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Exploring a complex adaptive systems approach to the study of urban change
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The impact of ai-driven hyper-personalisation within loyalty programs in South Africa
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ASTM assessment of a novel shoulder prosthetic design: measurement of glenoid edge motion in three degrees of freedom
Published 2025“…The block's motion is converted to complex glenoid edge motion using a MATLAB algorithm based on the system geometry. The test rig and edge motion measurement system were functionally validated in preliminary tests. …”
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Hydrodynamic added mass determination and attitude estimation of the Seahog - a remotely-operated underwater vehicle
Published 2020“…Prior to the commencement of this project, the Seahog was in a state where the basic functional units such as the thrusters, cameras, lights and power and communication systems were tested and installed. …”
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The prediction of the emission spectra of flares and solid propellant rockets
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A psychometric assessment of the Temperament and Character Inventory in a South African sample of police recruits
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Improvement of zein dough characteristics using dilute organic acids
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Monetary policy and economic performance - evidence from selected African countries
Published 2016“…Chapter Two tests the completeness of the pass-through of the central bank policy rate to bank lending rates on one hand, and the interest rate pass-through as a function of the level of financial development on the other hand. …”
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