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Investigating Tau Pathology in the Retina and Anterior Segment Structures of the Eye in a 3-Nitropropionic Acid–Induced Tauopathy Mouse Model
Published 2026“…Comprehensive neurobehavioral assessments evaluated anxiety-like behaviors (open field test, light-dark transition box), cognitive function (novel object recognition test), and depression-like phenotypes (forced swim test). …”
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The use of stochastic collocation for sampling from expensive distributions with applications in finance
Published 2016“…The points at which the interpolating polynomial is constructed to exactly match the true quantile-to-quantile transformation function are known as collocation points. Any number of realisations from the expensive distribution may be read off using the interpolating polynomial, leading to a significant reduction in computation time when compared to methods like the inverse transform method. …”
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Advanced analytics for process analysis of turbine plant and components
Published 2021“…The artificial neural network was of a multi-layer perceptron (MLP) type, using the rectified linear unit (ReLU) activation function, mean squared error (MSE) loss function and adaptive moments (Adam) optimiser. …”
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Novel insights into pollen movement and floral evolution revealed by quantum dots
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The role of steroidogenic factor-1 (SF-1) in gonadotropin-releasing hormone (GnRH) receptor gene regulation
Published 2018“…DNasel footprinting reveals that the major DNA-binding activity in αT3-1 cells on the GnRHR promoter occurs at the SF-1-like site. The SF-1-like sequence specificity of the interaction is demonstrated by gel redardation and DNasel footprinting assays using specific and mutated oligonucleotides as competitors. …”
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Investigating the effects of enhanced catecholamine stimulation in stem cell-derived cardiomyocytes
Published 2026“…As the atrial and ventricular pumping efficiency declines, this sympatho-overexcitation induces a compensatory stress response known as cardiac remodelling which adjusts the structure and function of mainly the myocardium to restore cardiac output. …”
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Artificial neural networks and the cross-section of equity returns: identifying nonlinear opportunities on the Johannesburg Stock Exchange
Published 2026“…The optimal neural network architecture is explored, considering varying model depths and node counts. The activation function, training algorithm, learning rate, number of epochs, batch size, and loss function are kept constant across architectures. …”
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In vitro modelling of cellular haemozoin and inhibition by β-haematin inhibitors and their derivatives
Published 2021“…Further investigations into the exchangeable haem amounts as a function of intracellular test compound amounts at the IC50 values of these β-haematin inhibitors highlighted that there was an apparent 1:1 relationship with the amount of intracellular exchangeable haem, indicative of complex formation. …”
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Essays on political economy using dynamic general equilibrium models
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Prevalence of Hepatitis B in HIV infected persons: choice of antiretroviral therapy regimen and implications for screening
Published 2015“…The relationship between Hepatitis B carriage and liver function was also determined in co-infected persons as measured by liver function tests. …”
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Cystic fibrosis in South Africa: spectrum of disease, diagnosis, and determinants of outcome
Published 2024“…Implications and novelty of this research are that existing reference ranges for this test may not be applicable in children, and confirmation that the β-adrenergic sweat test is a viable alternative for measuring CFTR function. …”
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Exploring a complex adaptive systems approach to the study of urban change
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Classical, quantum and numerical aspects of modified theories of gravity
Published 2024“…We then examine the quantumgravitational entanglement of two test masses that undergo a spatial splitting that is orthogonal to their separation. …”
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The impact of ai-driven hyper-personalisation within loyalty programs in South Africa
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Constitutive modelling of the skin accounting for chronological ageing
Published 2017“…A more complex loading condition is applied through bulge tests where a pressure is applied to an in vitro skin specimen. …”
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Assigning symmetry terms to molecular orbitals in asymmetric Fischer carbenes using FALDI in a theoretical study
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The effect of drought and rising temperatures on total factor productivity in pasture-based dairy farming in the Eastern Cape
Published 2022“…The translog functional form was chosen over Cobb Douglas based on another generalised likelihood ratio test. …”
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On the numerical solution of Fisher's and FitzHugh-Nagumo equations using some nite di erence methods
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