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Functional Genome-wide Association Studies (fGWAS) and genomics landscape of signatures of polygenic adaptation in Botswana populations with HIV-1 C infection by Choga, Wonderful Tatenda
Published 2023“…The best-fit prediction for Botswana was PT =0.129 (β=-120.02, standard error=61.14, pvalue=5.0x10-2) and 1.3% of the variance in HIV-1 susceptibility at the population level could be explained by the scores. …”
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Page will reload when a filter is selected or excluded.- " Background: HIV-2 is comparatively less pathogenic with slow progression of infection to clinical disease and consequently there is less of information on the occurrence of HIV-2 associated disease than HIV-1. We hereby describe some laboratory profiles of individuals presenting with HIV-2 and dual HIV-1/2 related AIDS at the University College hospital in Ibadan over a period of seven years. Methodology: Blood samples from patients presenting with the AIDS defining illness at the University College Hospital, Ibadan, Nigeria were tested for antibodies to HIV-1/2 using rapid test devices or ELISA. Initially reactive samples were further tested by immunoblotting for differentiation into HIV-1 or HIV-2 or HIV-1/2 dual infection. Blood samples from individuals with confirmed infections were further analyzed for CD4 cell lymphocyte number, plasma HIV-1 RNA concentration, hematological and blood chemistry parameters. The data analysis was done using descriptive statistics and Levene-S test for equality of variance. Results: Thirty five patients, 18 and 17 with HIV-2 and dual HIV-1/2 infections respectively were identified during the period covered by this study (2005-2012). The median age of the patients was 48 years old (Range: 42 - 70 years old) and mean CD4 cell count of HIV-2 patients at enrollment was 324 (Range: 16 - 696) and 350 (Range 54 - 863) per microlitre of blood for patients with dual HIV-1/2 infection. HIV-1 RNA was not detected in the plasma of the 18 patients with serological HIV-2 infection but 2 (11.8%) of the 17 patients with dual HIV-1/2 serological profile had detectable HIV-1 RNA (1,287,275 copies/ml and 1,816,491 copies/ml). Conclusion: The results emphasize the need to consider HIV-2 infection in the investigation of patients presenting with the AIDS related illness but with negative HIV-1serology. The study also shows the importance of inclusion of multispot HIV-1 and 2 rapid tests for differentiating HIV-1 from HIV-2 infections in regions where both types of HIV circulate or epidemiologically indicated. " 1 results 1
- After the discovery of indiscriminate antibiotic use in ready-for-slaughter cattle in south-western Nigeria, 90 tissue samples from randomly selected slaughtered cattle were evaluated for oxytetracycline and penicillin-G residues using high performance liquid chromatography and the data analysed by one-way Analysis of variance (ANOVA). The findings revealed residues of oxytetracycline (kidney: 9.47 μ/kg ± 3.24 μ/kg; liver: 12.73 μ/kg ± 4.39 μ/kg; muscle: 16.17 μ/kg ± 5.52 μ/kg) and penicillin-G (kidney: 6.27 μ/kg ± 2.46 μ/kg; liver: 8.5 μ/kg ± 2.80 μ/kg; muscle: 11.67 μ/kg ± 2.94 μ/kg) in all tissues screened. Significantly high levels (oxytetracycline: F = 16.77; penicillin-G: F = 29.38) were, however, found in muscles, followed by liver and then kidney – findings confirming recent antibiotic administration to the animals before slaughter. The dietary intakes through the tissues screened were 0.024% (oxytetracycline) and 0.017% (penicillin-G) of the acceptable daily intake (ADI). Although the concentrations in the tissues screened were below the maximum residue limits despite recent administration of these antibiotics before slaughter, the lower concentrations are suggestive of the probable low dosages often administered by those involved in indiscriminate use of antibiotics. This therefore raises serious concerns for the livestock industry as well as human health, given the resultant emergence and spread of resistant strains of bacterial pathogens that could ensue from prolonged use of low dosages of antibiotics. Additionally, the lower concentrations of the daily intakes notwithstanding, the plausible exposure to these antibiotics from other food sources is a cause for concern. Since antimicrobial misuse and its consequent effects are not just a problem limited to Nigeria but also a concern in sub-Saharan Africa, the need for national and international stakeholder intervention is emphasised. 1 results 1
- Ginger rhizomes 1 results 1
- Pre-storage treatment 1 results 1
- Purpose: Ginger rhizomes are highly susceptible to damage during postharvest storage due to soil borne pathogenic disorder. Experiments were conducted to evaluate the effects of prestorage treatments required for sprouting and maintaining the quality of ginger plant in different storage periods at the Teaching and Research Farm, Ladoke Akintola University of Technology, Ogbomoso. Method: The rhizomes were treated with four different pre-storage treatments viz.,control, hydrated lime, - Mancozeb, and 100ml of Trichodermaharzianum solution at different storage periods of one, two and three months. The experiment was arranged in a complete randomized designand laid out in a randomized complete block design with three replicates. Data were collected on percentage sprouting, plant height, number of leaves, leaf area and nutritional quality of ginger rhizomes. Data were subjected to analysis of variance using Statistical Analysis System Software (SAS, 2005). Differences among treatment means were compared using Least Significance Difference (LSD) at 5% probability level. Results: The storage periods significantly (P≤0.05) influenced the percentage sprouting andgrowth parametersof ginger at various sampling period. Highest growth of 9.05cm was recorded from ginger plant stored for three months while the least value of 6.94cm was obtained from rhizomes stored for one month. The pre-storage treatments significantly (P≤0.05) influenced the percentage sprouting, weight loss and growth parameters of ginger at various sampling period. Highest percentage sprouting (94.3%) was recorded from rhizomes treated with 100 ml Trichodermaharzianim solution followed by rhizomes treated with hydrated lime (88.3 %) while lowest percentage sprouting (61.5 %) were recorded from control. Highest percentage weight loss of 46.3% was recorded from control followed by hydrated lime (35.58 %) while the lowest percentage weight loss of 33.93 % was recorded from 100 ml Trichodermaharzianim solution. Conclusions: In conclusion, rhizomes treated with Trichodermaharzianim solution for a period of three months before planting produced better sprouting and enhanced the growth quality of ginger on the field 1 results 1
- Sprouting, nutritional quality 1 results 1
- Storage periods 1 results 1
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