Full Text Available
Access Full Text at Repository
Search Results - population variability analysis
- Go to Previous Page
- Showing 721 - 724 results of 724
-
Unlocking the potential of the emerging smallholder farming sector in South African agriculture : an agent-based approach by Zantsi, Siphe
Published 2021Get full text
ThesisFull Text AvailableAccess Full Text at Repository -
Pollinator-mediated floral diversication of annual dimorphotheca daisies in the Cape Floristic Region by Engelen, Arjan
Published 2025Get full text
ThesisFull Text AvailableAccess Full Text at Repository -
The relevance of the Greater Cederberg Biodiversity Corridor (GCBC) for reptile conservation by Meyer, Anita
Published 2012Get full text
ThesisFull Text AvailableAccess Full Text at Repository
Search Tools:
Refine Results
Page will reload when a filter is selected or excluded.- Nigeria 7 results 7
- Polymorphism 4 results 4
- Hypertension 3 results 3
- Allele and genotype 2 results 2
- Asejire Lake 2 results 2
- Efiks and Ibibios 2 results 2
- Genetic distance 2 results 2
- Genetic variation 2 results 2
- Hypertension is a public health challenge due to its high prevalence, and is a major risk factor for cardiovascular diseases. Hypertension is a complex disease resulting from an interaction of genes and environmental factors. Inconsistent association between polymorphisms of the renin angiotensin aldosterone, the atrial natriuretic peptide systems and hypertension has been reported among various ethnic groups, but not for the Efiks and Ibibios in south-south Nigeria. This study was designed to determine the frequency of gene polymorphisms of these two systems and their association with hypertension in Calabar and Uyo, Nigeria. A population-based case control design was used. A total of 1224 participants, 612 each of patients and controls were randomly recruited from hypertension clinics and the general population. Genotyping of the M235T allele of the angiotensinogen, Insertion/Deletion allele (I/D) of the angiotensinogen converting enzyme, A1166C allele of the angiotensin II type I receptor and C664G allele of the atrial natriuretic peptide genes to identify variants was performed using polymerase chain reaction and restriction enzyme digestion. The Hardy-Weinberg equation was used to calculate the allele and genotype frequencies. Plasma angiotensinogen levels were measured by Enzyme Linked Immunosorbent Assay. Hypertensinogenic factors such as age, familial history, physical exercise and drinking were assessed using questionnaires. Descriptive statistics, chi-square, multiple regression analysis and odds ratio were used to analyze the data. The frequency of the genotypes M235M, M235T, T235T of the M235T allele for the Efiks were 0.4, 7.7, 92 % in patients and 0, 6, 94 % in controls; for the Ibibios were 0.5, 1.2, 87 % in patients and 0, 7, 93 % in controls. The I/D genotypes II, ID, DD frequencies for the Efiks were 11, 44, 46 % in patients and 16, 45, 39 % in controls; for the Ibibios were 11, 40, 49 % in patients and 13, 49, 38 % in controls. The frequency of the A1166C carriers was 1 % while 99 % of the study population had the wild type A1166A genotype for the A1166C allele. Only the CC genotype was observed for the C664G allele. These frequencies did not conform to the Hardy-Weinberg assumptions. There were no significant differences between the genotype frequencies of patients and controls. Plasma angiotensinogen values were significantly higher in the patients with M235T allele than in the controls. Age was a positive predictor for systolic blood pressure (SBP, r = 0.60) in patients and diastolic blood pressure (DBP, r = 0.56) in controls. Other hypertensinogenic variables were not predictors for SBP and DBP in the population (p < 0.05). The Insertion/Deletion allele was a risk factor for hypertension, (O.R = 1.15). A high frequency was observed for the M235T allele and the Insertion/Deletion allele, which was associated with an increased risk for hypertension. The lack of association between the alleles of the M235T, A1166C and the C664G and hypertension suggests that other loci or environmental factors are involved in the disease outcome. 2 results 2
- Population structure 2 results 2
- Undergraduates 2 results 2
- "An individual's perception of and reactions to fairness in an organisation, is fundamental to human psychological and social interaction. The feeling of justice, be it promotional decision, assignment of tasks, allocation of rewards are germane to the psychological well-being of employees. It is against this background that the research looks into organisational justice and psychological well-being of employeesin the local government service of Osun State, Nigeria. The descriptive research design of the expost facto was used for the research. The population of this study consisted of staff of the Ministry of Local Government and all employees of the thirty Local Government Councils in Osun State. A multi-stage sampling technique was used for the selection of the 317 respondents used for the research. The main instrument used for the study is a questionnaire tagged ""Organisational Justice and Employees' Psychological Wellbeing Questionnaire (OJAEPWQ)"" with four sub-sections namely Distributive Justice Scale (DJS), Procedural Justice Scale (PJS), Interactional Justice Scale (IJS), Psychological Wellbeing Scale (PWS) with reliability coefficient of 0.79, 0.90, 0.86 and 0.87 respectively. Two research questions and three hypotheses were analyzed using multiple regression analysis and Pearson Product Moment Correlation at 0.05 level of significance. Findings showed the joint contribution of the three independent variables to the prediction of the dependent variable is significant (F(3,313)= 181.203). The relative contribution of the three independent variables to the dependent variable, expressed as beta weights are Distributive justice (β = 150, t=3.436, P<.05), Procedural justice (β= .247, t=5.537, P <.05) and Interactional justice (β= .511, t=10.305, P<.05). Furthermore, it was revealed that there was a significant relationship between distributive justice and psychological well-being (r=.583, n=317, P <.05). There was a significant relationship between procedural justice and psychological well-being (r=.643, n=317, P < .05) and that there was a significant relationship between interactional justice and psychological well-being (r = .760, n = 317, P < .05). Based on the above findings it was recommended that managements in organisations should give room for justice in such a way that the psychological well-being of employees in terms of their thoughts, feelings, emotions, understanding, perception and interpersonal relations are protected among others. " 1 results 1
- 'True' random effect 1 results 1
- Access to UBE 1 results 1
- Accessibility of records 1 results 1
- Achievement 1 results 1
- Adults 1 results 1
- Adverse drug reactions (ADRs) 1 results 1
- Agreeableness 1 results 1
- Alberta immigrants, 1 results 1
- Allozyme loci 1 results 1
- Attitude 1 results 1
- Autonomy 1 results 1
- Background Diabetes, particularly type 1 diabetes, at younger ages can be a largely preventable cause of death with the correct health care and services. We aimed to evaluate diabetes mortality and trends at ages younger than 25 years globally using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. Methods We used estimates of GBD 2019 to calculate international diabetes mortality at ages younger than 25 years in 1990 and 2019. Data sources for causes of death were obtained from vital registration systems, verbal autopsies, and other surveillance systems for 1990–2019. We estimated death rates for each location using the GBD Cause of Death Ensemble model. We analysed the association of age-standardised death rates per 100 000 population with the Socio-demographic Index (SDI) and a measure of universal health coverage (UHC) and described the variability within SDI quintiles. We present estimates with their 95% uncertainty intervals. Findings In 2019, 16 300 (95% uncertainty interval 14 200 to 18 900) global deaths due to diabetes (type 1 and 2 combined) occurred in people younger than 25 years and 73·7% (68·3 to 77·4) were classified as due to type 1 diabetes. The age-standardised death rate was 0·50 (0·44 to 0·58) per 100 000 population, and 15 900 (97·5%) of these deaths occurred in low to high-middle SDI countries. The rate was 0·13 (0·12 to 0·14) per 100 000 population in the high SDI quintile, 0·60 (0·51 to 0·70) per 100 000 population in the low-middle SDI quintile, and 0·71 (0·60 to 0·86) per 100 000 population in the low SDI quintile. Within SDI quintiles, we observed large variability in rates across countries, in part explained by the extent of UHC (r²=0·62). From 1990 to 2019, age-standardised death rates decreased globally by 17·0% (–28·4 to –2·9) for all diabetes, and by 21·0% (–33·0 to –5·9) when considering only type 1 diabetes. However, the low SDI quintile had the lowest decline for both all diabetes (–13·6% [–28·4 to 3·4]) and for type 1 diabetes (–13·6% [–29·3 to 8·9]). Interpretation Decreasing diabetes mortality at ages younger than 25 years remains an important challenge, especially in low and low-middle SDI countries. Inadequate diagnosis and treatment of diabetes is likely to be major contributor to these early deaths, highlighting the urgent need to provide better access to insulin and basic diabetes education and care. This mortality metric, derived from readily available and frequently updated GBD data, can help to monitor preventable diabetes-related deaths over time globally, aligned with the UN’s Sustainable Development Targets, and serve as an indicator of the adequacy of basic diabetes care for type 1 and type 2 diabetes across nations. 1 results 1
- Background. Small, uncontrolled studies of dialysis dependent chronic kidney disease (CKD) patients have demonstrated abnormalities of cardiovascular autonomic control and vascular compliance, which may contribute to adverse cardiovascular morbidity in this population. However, there is little information utilizing newer, noninvasive techniques in predialysis patients with increasing degrees of uremia. Methods. One hundred and five nondialysis CKD patients with a median GFR of 23 mL/min/1.73m2 (range: 6 to 102) at baseline were studied. Cardiac baroreceptor sensitivity (BRS) was recorded by time- and frequency-domain techniques, and its relationship with increasing degrees of uremia studied. During a mean follow-up period of 42 months (range: 3 to 70), primary (death, dialysis, transplantation) and secondary (fatal and nonfatal cardiovascular events) outcome measures were recorded. The importance of cardiac BRS in comparison to other important renal and cardiovascular prognostic variables in predicting outcome was assessed. Results. Median cardiac BRS by time domain analysis at baseline was 8.85 msec/mm Hg (interquartile range: 6.85), and impaired cardiac BRS was related to reduced GFR, increasing age, and hypertension on quantile regression analysis. ‘Impaired’ cardiac BRS was associated with a trend toward increased likelihood of both primary and secondary outcomes, and may act as a surrogate measure of other cardiovascular risk factors, including age, hyperlipidemia, hypertension, previous cardiovascular disease, and doubling of creatinine. Conclusion. Nondialysis-dependent CKD patients have impaired cardiac BRS, and this was related to decreasing GFR. There was a trend toward poorer prognosis in patients with impaired cardiac BRS that requires further study. Cardiac BRS may provide a simple, bedside, noninvasive assessment of overall cardiovascular risk in this population. 1 results 1
- Background: A major characteristic of all developing countries is rapid population growth which is due to high fertility, birth rates and poor utilization of contraceptive methods. This study therefore assessed the predictors of contraceptive implants utilization among women of reproductive age in Ondo State, Nigeria. Methods: A descriptive cross-sectional study design was used and a total of 230 women were selected by multi-stage sampling technique. Questionnaire administration was interviewer-based majority of the women could not read. Data analysis was con- ducted using SPSS version 23. Research questions and hypotheses were answered and tested with descriptive statistics (frequency, percentages), chi-square test of significance and binary logistic regression. Levels of significance was set at p ≤ 0.05. Results: The prevalence of contraceptive utilization (any method) and contraceptive implant utilization were 92.2% and 31.1% respectively. Variables such as education (72= 6.91, p = 0.03) and lack of counseling from providers (72 5.05, p = 0.03) were significantly associated with the utilization of contraceptive implant. These two variables were also the predictors of contraceptive implant utilization. Women with secondary and tertiary education have higher odds of utilizing contraceptive implants (OR = 1.21, 95% CI = 1.01-7.82, p = 0.04) and (OR = 2.53, 95% CI = 1.49-11.47, p = 0.03) compared to women who had primary or no education while those who claimed to be adequately counseled by providers are about two times more likely to use contraceptive implants (OR = 2.33, 95% CI = 1.08-5.51) Conclusion: This study showed the important role of education and health workers in providing information about contraceptive implants. Therefore, health workers' knowledge of family planning counseling and services should be constantly upgraded so as to improve their roles in educating, mobilizing, counseling the women regarding contraceptive implant insertion. 1 results 1
- Background: Documentation of adverse drug reactions (ADRs) is critical to a safe health delivery system. The aim of our study was to explore the prevalence of self-reported sulphonamide hypersensitivity reactions in a community based sample of the general population in Ibadan, Nigeria. We also examined sociodemographic factors associated with ADRs in the sample. Patients and Methods: The study was cross-sectional in design with study sites in urban, semiurban, and rural settlement areas. Pretested questionnaires were administered on a one-on-one basis by trained interviewers. Frequency tables and percentages were computed for various levels of the variables. Chi-square test was used to assess the relationship between sulphonamide hypersensitivity and variables such as sociodemographic characteristics of respondents, respondents' knowledge of drugs, as well as drug sources. Variables found to be significantly associated with sulphonamide hypersensitivity were further investigated using multiple logistic regressions analysis Results: Out of the 1062 respondents, 15.5% reported hypersensitivity to sulphonamides with skin reactions being the most prevalent. The proportion reporting ADRs was significantly higher among respondents with tertiary education (23.1%) than any other level of education (P = 0.008). In addition, individuals who were very knowledgeable about drug use (odds ratio[OR]: 2.07; 95% confidence interval [CI]: 1.15–3.73) and persons who got drugs from hospitals (OR: 2.00; 95% CI: 1.10–3.65) were more likely to report ADRs than those who were ignorant about drugs and those who purchased drugs from open markets, respectively. Conclusion: Prevalence of sulphonamide hypersensitivity is high among respondents, and ADRs is likely to be reported by people who are knowledgeable about drug use. 1 results 1
- Background: The burden of under-5 deaths is disproportionately high among poor households relative to economically viable ones in developing countries. Despite this, the factors driving this inequality has not been well explored. This study decomposed the contributions of the factors associated with wealth inequalities in under-5 deaths in low and middle-income countries (LMICs). Methods: We analysed data of 856,987 children from 66,495 neighbourhoods across 59 LMICs spanning recent Demographic and Health Surveys (2010-2018). Under-5 mortality was described as deaths among live births within 0 to 59 months of birth and it was treated as a dichotomous variable (dead or alive). The prevalence of under-five deaths was stratified using household wealth status. A Fairlie decomposition analysis was utilized to investigate the relative contribution of the factors associated with household wealth inequality in under-5 deaths at p<0.05. The WHO health equity assessment toolkit Plus was used to assess the diferences (D) ratios (R), population attributable risk (PAR), and population attributable fraction (PAF) in household wealth inequalities across the countries. Results: The proportion of children from poor households was 45%. The prevalence of under-5 deaths in all samples was 51 per 1000 children, with 60 per 1000 and 44 per 1000 among children from poor and non-poor households (p<0.001). The prevalence of under-5 deaths was higher among children from poor households than those from non-poor households in all countries except in Ethiopia, Tanzania, Zambia, Lesotho, Gambia and Sierra Leone, and in the Maldives. Thirty-four of the 59 countries showed significantly higher under-5 deaths in poor households than in non-poor households (pro-non-poor inequality) and no significant pro-poor inequality. Rural-urban contexts, maternal education, neighborhood socioeconomic status, sex of the child, toilet kinds, birth weight and preceding birth intervals, and sources of drinking water are the most significant drivers of pro-poor inequities in under-5 deaths in these countries. Conclusions: Individual-level and neighbourhood-level factors were associated with a high prevalence of under-5 deaths among poor households in LMICs. Interventions in countries should focus on reducing the gap between the poor and the rich as well as improve the education and livelihood of disadvantaged people. 1 results 1
- Bayesian analysis. 1 results 1
- Bird morphology 1 results 1
- see all…
- UCTD — University of Cape Town Open Access Repository 245 results 245
- SUNScholar — Stellenbosch University Repository 233 results 233
- UPSpace — University of Pretoria Institutional Repository 172 results 172
- AUC Knowledge Fountain — bepress 9 results 9
- KNUSTSpace — Kwame Nkrumah University of Science & Technology (Ghana) 9 results 9