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Addressing challenges in the treatment of tuberculosis and tuberculosis meningitis: a pharmacometric approach
Published 2025“…Linezolid CSF penetration increased with higher CSF total protein levels, peaking at 37%. Neither the duration of rifampicin co treatment nor the dose level (standard 10 mg/kg vs high 35 mg/kg) was found to affect xi linezolid pharmacokinetics. …”
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Virtual-reality blast scene modelling and reconstruction
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Computational QSAR & Molecular Docking of Anti- inflammatory Asthma Drugs Against Human Serum Albumin: A Computational Approach Towards Drug Design & Drug Discovery
Published 2023“…This work aims at the development of novel anti-inflammatory asthma drugs where the quantum chemical descriptors of eleven anti-inflammatory asthma drugs including Ambroxol, Amoxicillin, Budesonide, Fluticasone, Formoterol, Glycopyrrolate, Guaifenesin, Montelukast, Salbutamol, Silymarin, and Theophylline, were computed using B3LYP/6-311G++(d,p) level of theory implementing the geometry optimization. …”
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An FPGA implementation of an investigative many-core processor, Fynbos : in support of a Fortran autoparallelising software pipeline
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Agent-based model of the market penetration of a new product
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An efficient three-dimensional database driven approach for multi scale homogenization
Published 2020“…Capable of capturing the microscopic effects at the macro level, the FE2 method assigns a representative volume element (RVE) of the materials microstructure at points across the macroscopic sample. …”
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A search for tWZ production in the trilepton channel using Run 2 data from the ATLAS experiment
Published 2022“…An event selection scheme was developed using simulation to broadly suppress background events and to select signal events. …”
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Modelling Term and Inflation Risk Premia in the South African Bond Market
Published 2023“…Dynamics of the level, slope and curvature components of the US yield curves are compared to each other and to the estimated term premia. …”
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Bayesian analysis of historical functional linear models with application to air pollution forecasting
Published 2023“…Our focus is on the application of our method to forecast the level of daily atmospheric pollutants using meteorological information such as hourly records of temperature, humidity and wind speed from data collected by the City of Cape Town, South Africa. …”
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Choosing investment solutions for South African long-term investors with prospect theory-type risk preferences
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Modelling uncertainty of cost and time in infrastructure projects
Published 2020“…The developed hybrid tool models the main structures from the activity level to the entire highway project. Consequently, three identified uncertainties in the construction process of infrastructures, namely variability in the construction process, correlations between the costs, times and cost-time of construction activities and disruptive events, are modelled jointly at the construction activity level. …”
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Vibratory hammer compaction of bitumin stabilized materials
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A novel pseudo-azeotrope mosquito repellent mixture
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A Fixed Switching Frequency technique for finite-set model predictive control of power electronic converters
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Online traffic engineering for MPLS networks
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Managing nutrient flows into the Zandvlei Estuary, Cape Town using Sustainable Drainage Systems (SuDS)
Published 2023“…Of the many pollutants that flow into the estuary, elevated nutrient levels (specifically phosphorus and nitrogen) are a major concern because they can lead to eutrophication and excessive plant growth. …”
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Optimal control of a conventional hydropower system with hydrokinetic/wind powered pumpback operation
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