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DIAGNOSIS AND TREATMENT OF ÀMÓDI IN IFÁ DIVINATION AMONG THE YORUBA OF SOUTH WESTERN NIGERIA
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Page will reload when a filter is selected or excluded.- Brucellosis 4 results 4
- Glimepiride 4 results 4
- Haematology 4 results 4
- Interaction 4 results 4
- Metformin 4 results 4
- Mice 4 results 4
- Nigeria 4 results 4
- Oxidative stress 4 results 4
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- Toxicity 4 results 4
- Blood Glucose 3 results 3
- Carica Papaya Extract 3 results 3
- Chloramphenicol 3 results 3
- Inflammation 3 results 3
- Purpose: To investigate the interacting effects of co-administration of Carica papaya leaf extract on the hypoglycemic activity of metformin and glimepiride in an animal model. Method: Experimental factorial design was used to evaluate the individual and interaction influence of three variables ie nature (N), dose administered (C) and duration of administration (D), in a 23(=8) employed at two levels - ‘’high’’ and ‘‘low’’ - on blood glucose of diabetic rats on administration of ethanolic leaf extract of Carica papaya and two hypoglycemic agents, metformin and glimepiride. Unpaired t-test was used to test for significant difference due to administration of the combination Results: Extract of Carica papaya at 5.0 mg/kg produced significant blood glucose reduction with no significant reduction at the higher dose of 10 mg/kg (p>0.05). Changing nature from “low” (Carica papaya extract) to “high” (glimepiride or metformin) did not significantly change hypoglycemic activity. Generally, the ranking of the interacting effects was ND>CD>>NC for glimepiride/extract, and CD>ND>NC for metformin/extract. Administration of higher dose of the extract led to significant (p<0.01) increase in onset of activity of glimepiride. The onset of activity of metformin was not affected, but a significant lowering (p<0.05) of blood glucose was observed at 24 hr with all combinations of extract and metformin. Conclusion: Leaf extract of Carica papaya significantly delays the onset of hypoglycaemic activity of glimepiride, and increases the hypoglycaemic effect of metformin with the variablesinteracting differently for each drug-extract combinations. 3 results 3
- Reproductive dysfunction 3 results 3
- Africa 2 results 2
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- Cattle 2 results 2
- Chlorpyrifos 2 results 2
- Escherichia coli 2 results 2
- Funisciurus anerythrus 2 results 2
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