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Preformulation solid-state supramolecular beneficiation of selected active pharmaceutical ingredients and a novel drug candidate
Published 2019“…The compounds selected were: Clevudine, an established drug that is currently in use for the treatment of chronic hepatitis B infections, 6-(3- (Methylsulfonyl)phenyl)-3-(4-(methylsulfonyl)phenyl)-imidazo[1,2-b]pyridazine (MMV652103), a novel antimalarial drug candidate that displayed good in vitro potency against multidrug resistant and sensitive plasmodial strains and ()-α-lipoamide, a bioactive antioxidant that is currently in use for the clinical treatment of diabetic neuropathy and has other potential uses e.g. as an antiretroviral agent. The methods utilised in pursuit of novel solid-state forms of the compounds included a combination of crystal engineering and experimental screening for polymorphs, solvates/hydrates, cyclodextrin (CD) inclusion complexes, pharmaceutical salts and co-crystals. …”
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Model based fault detection and isolation approach for actuator and sensor faults in a UAV
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Subsynchronous resonance in series compensated networks with high penetration of renewable energy sources
Published 2022“…The dissertation dissects the SSR problem with emphasis on its management in a modern power system environment receiving rising RES and flexible alternating current transmission systems (FACTS) connections through series compensated lines. The simulations performed in this study utilised the IEEE first benchmark model (FBM) within Digital Simulation and Electrical Network – PowerFactory (DIgSILENT) software. …”
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Exploring consumers’ risk perception in wine retail decision-making : insights for Chenin blanc
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Chaos diagram of harmonically excited vibration absorber control duffing's oscillator
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The economic burden, patients' well-being, and social determinants related to diabetes in South Africa
Published 2025“…Furthermore, analysis utilising cross-sectional data of 539 participants older than 18 years receiving care from rural and urban clinics in the Western Cape, South Africa, revealed that healthcare utilisation was inversely related to diabetes self-care scores, indicating that patients with less frequent healthcare visits tended to have higher self-care scores. …”
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Modelling the behaviour of steel fibre reinforced concrete pavements
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Essential amino acid requirements for growth in woolled sheep
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Orthogonal Frequency Division Multiplexing Modelling
Published 2022“…Using OFDM modulation techniques, a multipath channel was investigated for realistic simulations. In MATLAB, a picture was used as the input signal to identify the OFDM modulation method with the lowest bit error rate (BER). …”
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Mechanisms for effective implementation of South Africa's National Minimum Wage
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Condition Monitoring of VSD-fed Induction Motors
Published 2024“…A similar trend is observed in speed and torque pulsations of the motor under the respective faults. Similarly, the method of diagnostic variables has proven valid for both simulation and experimental results and is able to detect and localise inverter open switch fault for single and double switch fault. …”
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Micro combined heat and power management for a residential system
Published 2016“…A model of a residential μCHP system is formulated upon which these simulated tests are conducted. From these simulations, equations to model the costs of running a fuel-cell based μCHP system are proposed. …”
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Development of an indoor positioning system to create a digital shadow of production plant layouts
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The financial inclusion status of rural households in Eswatini
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