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Nanostructured scaffold for neural tissue regeneration
Neural regeneration treatment after spinal cord injury (SCI) is still unsatisfactory despite the advances made in the field. One of the main challenges in neural tissue engineering is the axonal growth and directionality. Cell and molecular therapies can enhance the axonal attachment and growth. How...
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2018
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| _version_ | 1867613410301050880 |
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| access_status_str | Open Access |
| author | Abbas, Walaa |
| author_browse | Abbas, Walaa |
| author_facet | Abbas, Walaa |
| author_sort | Abbas, Walaa |
| collection | Thesis |
| dc_rights_str_mv | The author retains all rights with regard to copyright. The author certifies that written permission from the owner(s) of third-party copyrighted matter included in the thesis, dissertation, paper, or record of study has been obtained. The author further certifies that IRB approval has been obtained for this thesis, or that IRB approval is not necessary for this thesis. Insofar as this thesis, dissertation, paper, or record of study is an educational record as defined in the Family Educational Rights and Privacy Act (FERPA) (20 USC 1232g), the author has granted consent to disclosure of it to anyone who requests a copy. |
| description | Neural regeneration treatment after spinal cord injury (SCI) is still unsatisfactory despite the advances made in the field. One of the main challenges in neural tissue engineering is the axonal growth and directionality. Cell and molecular therapies can enhance the axonal attachment and growth. However, axons may be unsuccessful to maintain their native organization and may grow in a disorganized fashion. Nanofiber scaffolds represent a potential solution for the problem of nerve regeneration and axon extension, as they can mimic the neural tissue extra cellular matrix (ECM) and combine the advantages of the combinatorial therapy for nerve injury in SCI cases. In this work, we aimed to fabricate a nanostructured scaffold that can be used as a physical support for maintaining axonal growth and regeneration in the lesion site and provide the suitable environment for axonal extension to reconnect with their target neurons and restore their functional recovery. Characterization techniques such as Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), and Fourier transform infrared spectroscopy (FTIR) were done and the material was optimized to mimic the properties of the natural environment of the neural tissue in terms of biological and architectural properties. The results revealed that the material does mimic the properties of the neural tissues and can be considered a regenerative treatment for SCI. |
| format | Thesis |
| id | oai:fount.aucegypt.edu:etds-1466 |
| institution | American University in Cairo (Egypt) |
| last_indexed | 2026-06-10T12:35:42.290Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from AUC Knowledge Fountain — bepress |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
| publisher | AUC Knowledge Fountain |
| publisherStr | AUC Knowledge Fountain |
| record_format | dspace |
| source_str | AUC Knowledge Fountain — bepress |
| spelling | oai:fount.aucegypt.edu:etds-1466 Nanostructured scaffold for neural tissue regeneration Abbas, Walaa Neural regeneration treatment after spinal cord injury (SCI) is still unsatisfactory despite the advances made in the field. One of the main challenges in neural tissue engineering is the axonal growth and directionality. Cell and molecular therapies can enhance the axonal attachment and growth. However, axons may be unsuccessful to maintain their native organization and may grow in a disorganized fashion. Nanofiber scaffolds represent a potential solution for the problem of nerve regeneration and axon extension, as they can mimic the neural tissue extra cellular matrix (ECM) and combine the advantages of the combinatorial therapy for nerve injury in SCI cases. In this work, we aimed to fabricate a nanostructured scaffold that can be used as a physical support for maintaining axonal growth and regeneration in the lesion site and provide the suitable environment for axonal extension to reconnect with their target neurons and restore their functional recovery. Characterization techniques such as Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), and Fourier transform infrared spectroscopy (FTIR) were done and the material was optimized to mimic the properties of the natural environment of the neural tissue in terms of biological and architectural properties. The results revealed that the material does mimic the properties of the neural tissues and can be considered a regenerative treatment for SCI. 2018-02-01T08:00:00Z thesis text/html https://fount.aucegypt.edu/etds/467 https://fount.aucegypt.edu/context/etds/article/1466/type/native/viewcontent/Walaa_20Abbas_NANO_thesis_2017_Sep.11.pdf_sequence_1 The author retains all rights with regard to copyright. The author certifies that written permission from the owner(s) of third-party copyrighted matter included in the thesis, dissertation, paper, or record of study has been obtained. The author further certifies that IRB approval has been obtained for this thesis, or that IRB approval is not necessary for this thesis. Insofar as this thesis, dissertation, paper, or record of study is an educational record as defined in the Family Educational Rights and Privacy Act (FERPA) (20 USC 1232g), the author has granted consent to disclosure of it to anyone who requests a copy. Theses and Dissertations AUC Knowledge Fountain Neural Scaffolds Polymers NA NA |
| spellingShingle | Neural Scaffolds Polymers NA NA Abbas, Walaa Nanostructured scaffold for neural tissue regeneration |
| title | Nanostructured scaffold for neural tissue regeneration |
| title_full | Nanostructured scaffold for neural tissue regeneration |
| title_fullStr | Nanostructured scaffold for neural tissue regeneration |
| title_full_unstemmed | Nanostructured scaffold for neural tissue regeneration |
| title_short | Nanostructured scaffold for neural tissue regeneration |
| title_sort | nanostructured scaffold for neural tissue regeneration |
| topic | Neural Scaffolds Polymers NA NA |
| url | https://fount.aucegypt.edu/etds/467 https://fount.aucegypt.edu/context/etds/article/1466/type/native/viewcontent/Walaa_20Abbas_NANO_thesis_2017_Sep.11.pdf_sequence_1 |
| work_keys_str_mv | AT abbaswalaa nanostructuredscaffoldforneuraltissueregeneration |