Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
REST/NRSF is a master negative transcriptional factor for neurogenic program by maintaining stem cell quiescence in adult hippocampal neurogenesis
Adult neurogenesis occurs in two distinct regions inside the brain, the subventricular zone (SVZ) in the lateral ventricle and the subgranular zone (SGZ) of the dentate gyrus in hippocampus. Neural stem cells (NSCs) are controlled by several intrinsic and extrinsic factors that regulate their prolif...
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis |
| Published: |
AUC Knowledge Fountain
2011
|
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867613416445706240 |
|---|---|
| access_status_str | Open Access |
| author | Abdelhamid, Mostafa Nashaat Ahmed |
| author_browse | Abdelhamid, Mostafa Nashaat Ahmed |
| author_facet | Abdelhamid, Mostafa Nashaat Ahmed |
| author_sort | Abdelhamid, Mostafa Nashaat Ahmed |
| collection | Thesis |
| dc_rights_str_mv | The author retains all rights with regard to copyright. The author certifies that written permission from the owner(s) of third-party copyrighted matter included in the thesis, dissertation, paper, or record of study has been obtained. The author further certifies that IRB approval has been obtained for this thesis, or that IRB approval is not necessary for this thesis. Insofar as this thesis, dissertation, paper, or record of study is an educational record as defined in the Family Educational Rights and Privacy Act (FERPA) (20 USC 1232g), the author has granted consent to disclosure of it to anyone who requests a copy. |
| description | Adult neurogenesis occurs in two distinct regions inside the brain, the subventricular zone (SVZ) in the lateral ventricle and the subgranular zone (SGZ) of the dentate gyrus in hippocampus. Neural stem cells (NSCs) are controlled by several intrinsic and extrinsic factors that regulate their proliferation, survival and differentiation in the adult hippocampus. REST/NRSF is considered a master transcription factor that regulates hundreds of neuronal genes essential for neuronal fate decision. In this study, we address the role of REST/NRSF (RE1 silencing transcription factor/Neuro-restrictive silencer factor) in regulating adult neurogenesis in hippocampus.REST/NRSF has biphasic expression in neural stem cells and mature neurons. It serves as a critical controller of neural stem cell fate transition and neuronal differentiation.REST/NRSF maintains neural stem cell quiescence preventing its precocious differentiation into neurons. This study shows that deregulation of REST/NRSF function, conditional deletion in REST/NRSF allele, in vivo leads to a transient increase in adult hippocampal neurogenesis and NSCs exit quiescence. Consequently, this reflects a decrease in newborn neurons due to stem cell pool exhaustion. Our work asserts on the critical role of REST/NRSF as a negative master regulator for adult neurogenesis. The results offer a new horizon for the role of NRSF in regenerative medicine and development of new treatment strategies for cancer research. |
| format | Thesis |
| id | oai:fount.aucegypt.edu:etds-2191 |
| institution | American University in Cairo (Egypt) |
| last_indexed | 2026-06-10T12:35:47.730Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from AUC Knowledge Fountain — bepress |
| publishDate | 2011 |
| publishDateRange | 2011 |
| publishDateSort | 2011 |
| publisher | AUC Knowledge Fountain |
| publisherStr | AUC Knowledge Fountain |
| record_format | dspace |
| source_str | AUC Knowledge Fountain — bepress |
| spelling | oai:fount.aucegypt.edu:etds-2191 REST/NRSF is a master negative transcriptional factor for neurogenic program by maintaining stem cell quiescence in adult hippocampal neurogenesis Abdelhamid, Mostafa Nashaat Ahmed Adult neurogenesis occurs in two distinct regions inside the brain, the subventricular zone (SVZ) in the lateral ventricle and the subgranular zone (SGZ) of the dentate gyrus in hippocampus. Neural stem cells (NSCs) are controlled by several intrinsic and extrinsic factors that regulate their proliferation, survival and differentiation in the adult hippocampus. REST/NRSF is considered a master transcription factor that regulates hundreds of neuronal genes essential for neuronal fate decision. In this study, we address the role of REST/NRSF (RE1 silencing transcription factor/Neuro-restrictive silencer factor) in regulating adult neurogenesis in hippocampus.REST/NRSF has biphasic expression in neural stem cells and mature neurons. It serves as a critical controller of neural stem cell fate transition and neuronal differentiation.REST/NRSF maintains neural stem cell quiescence preventing its precocious differentiation into neurons. This study shows that deregulation of REST/NRSF function, conditional deletion in REST/NRSF allele, in vivo leads to a transient increase in adult hippocampal neurogenesis and NSCs exit quiescence. Consequently, this reflects a decrease in newborn neurons due to stem cell pool exhaustion. Our work asserts on the critical role of REST/NRSF as a negative master regulator for adult neurogenesis. The results offer a new horizon for the role of NRSF in regenerative medicine and development of new treatment strategies for cancer research. 2011-02-01T08:00:00Z thesis application/pdf https://fount.aucegypt.edu/etds/1192 https://fount.aucegypt.edu/context/etds/article/2191/viewcontent/2010biotmostafaabdelhamid.pdf The author retains all rights with regard to copyright. The author certifies that written permission from the owner(s) of third-party copyrighted matter included in the thesis, dissertation, paper, or record of study has been obtained. The author further certifies that IRB approval has been obtained for this thesis, or that IRB approval is not necessary for this thesis. Insofar as this thesis, dissertation, paper, or record of study is an educational record as defined in the Family Educational Rights and Privacy Act (FERPA) (20 USC 1232g), the author has granted consent to disclosure of it to anyone who requests a copy. Theses and Dissertations AUC Knowledge Fountain |
| spellingShingle | Abdelhamid, Mostafa Nashaat Ahmed REST/NRSF is a master negative transcriptional factor for neurogenic program by maintaining stem cell quiescence in adult hippocampal neurogenesis |
| title | REST/NRSF is a master negative transcriptional factor for neurogenic program by maintaining stem cell quiescence in adult hippocampal neurogenesis |
| title_full | REST/NRSF is a master negative transcriptional factor for neurogenic program by maintaining stem cell quiescence in adult hippocampal neurogenesis |
| title_fullStr | REST/NRSF is a master negative transcriptional factor for neurogenic program by maintaining stem cell quiescence in adult hippocampal neurogenesis |
| title_full_unstemmed | REST/NRSF is a master negative transcriptional factor for neurogenic program by maintaining stem cell quiescence in adult hippocampal neurogenesis |
| title_short | REST/NRSF is a master negative transcriptional factor for neurogenic program by maintaining stem cell quiescence in adult hippocampal neurogenesis |
| title_sort | rest nrsf is a master negative transcriptional factor for neurogenic program by maintaining stem cell quiescence in adult hippocampal neurogenesis |
| url | https://fount.aucegypt.edu/etds/1192 https://fount.aucegypt.edu/context/etds/article/2191/viewcontent/2010biotmostafaabdelhamid.pdf |
| work_keys_str_mv | AT abdelhamidmostafanashaatahmed restnrsfisamasternegativetranscriptionalfactorforneurogenicprogrambymaintainingstemcellquiescenceinadulthippocampalneurogenesis |