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A Preliminary Investigation of Neuroantibody Levels, Prevalence, and Environmental Factors in Patients with Neurological Dysfunction
Nervous system damage comprises a large proportion of diseases worldwide. It is also the most difficult to diagnose. Biomarkers for nervous system damage are needed in order to diagnose these diseases early enough to allow for intervention. In this study, we recruited patients from two Egyptian hosp...
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AUC Knowledge Fountain
2022
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| _version_ | 1867613420103139328 |
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| access_status_str | Open Access |
| author | Azar, Jihan |
| author_browse | Azar, Jihan |
| author_facet | Azar, Jihan |
| author_sort | Azar, Jihan |
| collection | Thesis |
| description | Nervous system damage comprises a large proportion of diseases worldwide. It is also the most difficult to diagnose. Biomarkers for nervous system damage are needed in order to diagnose these diseases early enough to allow for intervention. In this study, we recruited patients from two Egyptian hospitals with MCI, ET and NMS and health references. Serum autoantibody levels against neural proteins and heavy metals were analyzed and compared. Immunoglobulin G (IgG) antibodies against neurofilament H (NFH), Glial Fibrillary Acidic Protein (GFAP), Myelin Basic Protein (MBP) and alpha synuclein (a-SYN) and Immunoglobulin M (IgM) antibody against neurofilament light (NFL) were among the most significant promising biomarkers of nervous system damage. Among the heavy metals, Zn and Pb were the most significant showing an association with neurotoxicity and had a positive correlation with the aforementioned autoantibodies. To conclude, this is a case-control study of 94 patients to determine general biomarkers of nervous system damage. This study gives us a new insight about the pathogenesis of these diseases and provides a starting point for more research in this area of biomarkers research in neurodegenerative diseases. |
| format | Thesis |
| id | oai:fount.aucegypt.edu:etds-2717 |
| institution | American University in Cairo (Egypt) |
| last_indexed | 2026-06-10T12:35:51.500Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from AUC Knowledge Fountain — bepress |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | AUC Knowledge Fountain |
| publisherStr | AUC Knowledge Fountain |
| record_format | dspace |
| source_str | AUC Knowledge Fountain — bepress |
| spelling | oai:fount.aucegypt.edu:etds-2717 A Preliminary Investigation of Neuroantibody Levels, Prevalence, and Environmental Factors in Patients with Neurological Dysfunction Azar, Jihan Nervous system damage comprises a large proportion of diseases worldwide. It is also the most difficult to diagnose. Biomarkers for nervous system damage are needed in order to diagnose these diseases early enough to allow for intervention. In this study, we recruited patients from two Egyptian hospitals with MCI, ET and NMS and health references. Serum autoantibody levels against neural proteins and heavy metals were analyzed and compared. Immunoglobulin G (IgG) antibodies against neurofilament H (NFH), Glial Fibrillary Acidic Protein (GFAP), Myelin Basic Protein (MBP) and alpha synuclein (a-SYN) and Immunoglobulin M (IgM) antibody against neurofilament light (NFL) were among the most significant promising biomarkers of nervous system damage. Among the heavy metals, Zn and Pb were the most significant showing an association with neurotoxicity and had a positive correlation with the aforementioned autoantibodies. To conclude, this is a case-control study of 94 patients to determine general biomarkers of nervous system damage. This study gives us a new insight about the pathogenesis of these diseases and provides a starting point for more research in this area of biomarkers research in neurodegenerative diseases. 2022-05-12T07:00:00Z thesis application/pdf https://fount.aucegypt.edu/etds/1686 https://fount.aucegypt.edu/context/etds/article/2717/viewcontent/auto_convert.pdf Theses and Dissertations AUC Knowledge Fountain Biomarkers; NFH; Neuroantibodies; NFL; NFM; GFAP; MBP; a-SYN; Diagnosis; Nervous System; Vascular Dementia; Essential Tremor; Neuroleptic Malignant Syndrome; Heavy Metals. Nervous System Diseases Neurosciences |
| spellingShingle | Biomarkers; NFH; Neuroantibodies; NFL; NFM; GFAP; MBP; a-SYN; Diagnosis; Nervous System; Vascular Dementia; Essential Tremor; Neuroleptic Malignant Syndrome; Heavy Metals. Nervous System Diseases Neurosciences Azar, Jihan A Preliminary Investigation of Neuroantibody Levels, Prevalence, and Environmental Factors in Patients with Neurological Dysfunction |
| title | A Preliminary Investigation of Neuroantibody Levels, Prevalence, and Environmental Factors in Patients with Neurological Dysfunction |
| title_full | A Preliminary Investigation of Neuroantibody Levels, Prevalence, and Environmental Factors in Patients with Neurological Dysfunction |
| title_fullStr | A Preliminary Investigation of Neuroantibody Levels, Prevalence, and Environmental Factors in Patients with Neurological Dysfunction |
| title_full_unstemmed | A Preliminary Investigation of Neuroantibody Levels, Prevalence, and Environmental Factors in Patients with Neurological Dysfunction |
| title_short | A Preliminary Investigation of Neuroantibody Levels, Prevalence, and Environmental Factors in Patients with Neurological Dysfunction |
| title_sort | preliminary investigation of neuroantibody levels prevalence and environmental factors in patients with neurological dysfunction |
| topic | Biomarkers; NFH; Neuroantibodies; NFL; NFM; GFAP; MBP; a-SYN; Diagnosis; Nervous System; Vascular Dementia; Essential Tremor; Neuroleptic Malignant Syndrome; Heavy Metals. Nervous System Diseases Neurosciences |
| url | https://fount.aucegypt.edu/etds/1686 https://fount.aucegypt.edu/context/etds/article/2717/viewcontent/auto_convert.pdf |
| work_keys_str_mv | AT azarjihan apreliminaryinvestigationofneuroantibodylevelsprevalenceandenvironmentalfactorsinpatientswithneurologicaldysfunction AT azarjihan preliminaryinvestigationofneuroantibodylevelsprevalenceandenvironmentalfactorsinpatientswithneurologicaldysfunction |