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Investigating the Association Between Gut Bacteria and Childhood Neuropsychiatric Disorders
Background: The etiology of autism spectrum disorder (ASD) remains unclear. However, it’s believed to be a multifactorial condition. Several studies suggest the involvement of gut and oral microbiome in the predisposition of ASD symptoms. Understanding the pathophysiology could aid in developing bet...
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AUC Knowledge Fountain
2024
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| _version_ | 1867613423008743424 |
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| access_status_str | Open Access |
| author | Abdo, Maha |
| author_browse | Abdo, Maha |
| author_facet | Abdo, Maha |
| author_sort | Abdo, Maha |
| collection | Thesis |
| description | Background: The etiology of autism spectrum disorder (ASD) remains unclear. However, it’s believed to be a multifactorial condition. Several studies suggest the involvement of gut and oral microbiome in the predisposition of ASD symptoms. Understanding the pathophysiology could aid in developing better treatment strategies that improve the quality of life of ASD individuals and their caregivers.
Aim: The current study aims at characterizing the gut and oral microbiome composition of ASD children compared to their healthy siblings and mothers as control groups.
Methods: Stool and saliva samples were collected from fourteen families at Ain Shams University Hospital, Outpatient Clinic. The 16S rRNA V3-V4 hypervariable regions of the bacterial DNA extracted from the samples were sequenced and then analyzed using QIIME2 and R studio.
Results: Several bacterial taxa belonging to phylum Actinobacteriota were differentially abundant in the study groups’ saliva and stool samples. Additionally, a reduction in butyrate-producing bacteria was seen in ASD stool samples.
Conclusion: The current study provides evidence of altered microbiota composition in ASD children. However, future large-scale studies would give a better picture of the observed dysbiosis and possible ways to correct it. |
| format | Thesis |
| id | oai:fount.aucegypt.edu:etds-3228 |
| institution | American University in Cairo (Egypt) |
| last_indexed | 2026-06-10T12:35:54.296Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from AUC Knowledge Fountain — bepress |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | AUC Knowledge Fountain |
| publisherStr | AUC Knowledge Fountain |
| record_format | dspace |
| source_str | AUC Knowledge Fountain — bepress |
| spelling | oai:fount.aucegypt.edu:etds-3228 Investigating the Association Between Gut Bacteria and Childhood Neuropsychiatric Disorders Abdo, Maha Background: The etiology of autism spectrum disorder (ASD) remains unclear. However, it’s believed to be a multifactorial condition. Several studies suggest the involvement of gut and oral microbiome in the predisposition of ASD symptoms. Understanding the pathophysiology could aid in developing better treatment strategies that improve the quality of life of ASD individuals and their caregivers. Aim: The current study aims at characterizing the gut and oral microbiome composition of ASD children compared to their healthy siblings and mothers as control groups. Methods: Stool and saliva samples were collected from fourteen families at Ain Shams University Hospital, Outpatient Clinic. The 16S rRNA V3-V4 hypervariable regions of the bacterial DNA extracted from the samples were sequenced and then analyzed using QIIME2 and R studio. Results: Several bacterial taxa belonging to phylum Actinobacteriota were differentially abundant in the study groups’ saliva and stool samples. Additionally, a reduction in butyrate-producing bacteria was seen in ASD stool samples. Conclusion: The current study provides evidence of altered microbiota composition in ASD children. However, future large-scale studies would give a better picture of the observed dysbiosis and possible ways to correct it. 2024-01-31T08:00:00Z thesis application/pdf https://fount.aucegypt.edu/etds/2189 https://fount.aucegypt.edu/context/etds/article/3228/viewcontent/Maha_El_Saeed_Abdo_Thesis.pdf Theses and Dissertations AUC Knowledge Fountain Autism Spectrum Disorder oral microbiome gut microbiome dysbiosis Development Studies Neurosciences Psychiatric and Mental Health |
| spellingShingle | Autism Spectrum Disorder oral microbiome gut microbiome dysbiosis Development Studies Neurosciences Psychiatric and Mental Health Abdo, Maha Investigating the Association Between Gut Bacteria and Childhood Neuropsychiatric Disorders |
| title | Investigating the Association Between Gut Bacteria and Childhood Neuropsychiatric Disorders |
| title_full | Investigating the Association Between Gut Bacteria and Childhood Neuropsychiatric Disorders |
| title_fullStr | Investigating the Association Between Gut Bacteria and Childhood Neuropsychiatric Disorders |
| title_full_unstemmed | Investigating the Association Between Gut Bacteria and Childhood Neuropsychiatric Disorders |
| title_short | Investigating the Association Between Gut Bacteria and Childhood Neuropsychiatric Disorders |
| title_sort | investigating the association between gut bacteria and childhood neuropsychiatric disorders |
| topic | Autism Spectrum Disorder oral microbiome gut microbiome dysbiosis Development Studies Neurosciences Psychiatric and Mental Health |
| url | https://fount.aucegypt.edu/etds/2189 https://fount.aucegypt.edu/context/etds/article/3228/viewcontent/Maha_El_Saeed_Abdo_Thesis.pdf |
| work_keys_str_mv | AT abdomaha investigatingtheassociationbetweengutbacteriaandchildhoodneuropsychiatricdisorders |