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Cell-Type-Specific Regulon Activity Alterations Across Alzheimer’s Disease, Parkinson’s Disease, and Frontotemporal Dementia

Alzheimer’s disease (AD), Parkinson’s disease (PD), and frontotemporal dementia (FTD) exhibit distinct but partially overlapping molecular features. However, the extent to which cell-type-specific transcription factor (TF)-associated regulatory alterations recur across these disorders remains incomp...

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Main Author: Mohamed, Sherine Khalafalla Saber Ahmed
Format: Thesis
Published: AUC Knowledge Fountain 2026
Subjects:
Single-nucleus RNA sequencing; Comparative single-cell transcriptomics; Gene regulatory networks; Regulon activity; Transcription factors; Cell-type-specific regulation; Neurodegenerative diseases; Alzheimer’s disease; Parkinson’s disease; Frontotemporal dementia
Bioinformatics
Computational Biology
Molecular and Cellular Neuroscience
Nervous System Diseases
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