Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
Hydroethanolic Extracts of Ficus pumila Linn. Is Protective against Gentamicin-Induced Kidney Damage in Rats
This article is published in Journal of Advances in Medical and Pharmaceutical Sciences and also available at 10.9734/JAMPS/2018/41291
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Journal of Advances in Medical and Pharmaceutical Sciences
2020
|
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867613136604889088 |
|---|---|
| access_status_str | Open Access |
| author | Larbie, Christopher Siaw, Portia A Zon, Solomon Appiah-Kubi, Kwame |
| author_browse | Appiah-Kubi, Kwame Larbie, Christopher Siaw, Portia A Zon, Solomon |
| author_facet | Larbie, Christopher Siaw, Portia A Zon, Solomon Appiah-Kubi, Kwame |
| author_sort | Larbie, Christopher |
| collection | Thesis |
| description | This article is published in Journal of Advances in Medical and Pharmaceutical Sciences and also available at 10.9734/JAMPS/2018/41291 |
| format | Article |
| id | oai:ir.knust.edu.gh:123456789/13114 |
| institution | KNUST (Ghana) |
| language | English |
| last_indexed | 2026-06-10T12:31:21.331Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from KNUSTSpace — Kwame Nkrumah University of Science & Technology (Ghana) |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Journal of Advances in Medical and Pharmaceutical Sciences |
| publisherStr | Journal of Advances in Medical and Pharmaceutical Sciences |
| record_format | dspace |
| source_str | KNUSTSpace — Kwame Nkrumah University of Science & Technology (Ghana) |
| spelling | oai:ir.knust.edu.gh:123456789/13114 Hydroethanolic Extracts of Ficus pumila Linn. Is Protective against Gentamicin-Induced Kidney Damage in Rats Larbie, Christopher Siaw, Portia A Zon, Solomon Appiah-Kubi, Kwame This article is published in Journal of Advances in Medical and Pharmaceutical Sciences and also available at 10.9734/JAMPS/2018/41291 N(3%1(2 Linn. has been reported to be rich in phenols, hepatoprotective and antiproliferative on leukemic cancer cells. The aim of this study was to evaluate the nephroprotective effect of hydroethanolic leaves extracts of N5%1(2 on gentamicin-induced kidney damage in rats. Twentyseven female Wistar albino rats were divided into 9 groups (n=3). Group 1 being normal; group 2 was the gentamicin (GM) induced only (80 mg/kg b/w ip for 5 days); groups 3, 4, & 5 rats were treated with gentamicin (80mg/kg b/w ip for 5 days) and N5%1(2 extract at 100, 250, and 500 mg/kg b/w orally respectively; groups 6, 7 & 8 rats received the extract only (100, 250, and 500 mg/kg b/w orally) respectively and group 9 being gentamicin and silymarin (100 mg/kg b/w orally) for 21 days. Blood samples were taken 24 hrs after the experimented period and biochemical and haematological parameters were analyzed. GM nephrotoxicity was characterized by significantly increased levels of serum creatinine, urea, sodium, potassium and WBC, while reduced RBC, HGB, MCH and MCV levels compared with normal group. Rats treated with gentamicin and the extract showed a significant reduction in the levels of these markers. The results suggest that hydroethanolic extract of N(3%1(2 leaves protect against gentamicin-induced nephrotoxicity in female Wistar albino rats. KNUST 2020-09-28T15:25:03Z 2023-04-19T02:16:44Z 2020-09-28T15:25:03Z 2023-04-19T02:16:44Z 2018-06 Article Journal of Advances in Medical and Pharmaceutical Sciences ,17(2): 1-8 10.9734/JAMPS/2018/41291 https://ir.knust.edu.gh/handle/123456789/13114 en application/pdf Journal of Advances in Medical and Pharmaceutical Sciences |
| spellingShingle | Larbie, Christopher Siaw, Portia A Zon, Solomon Appiah-Kubi, Kwame Hydroethanolic Extracts of Ficus pumila Linn. Is Protective against Gentamicin-Induced Kidney Damage in Rats |
| title | Hydroethanolic Extracts of Ficus pumila Linn. Is Protective against Gentamicin-Induced Kidney Damage in Rats |
| title_full | Hydroethanolic Extracts of Ficus pumila Linn. Is Protective against Gentamicin-Induced Kidney Damage in Rats |
| title_fullStr | Hydroethanolic Extracts of Ficus pumila Linn. Is Protective against Gentamicin-Induced Kidney Damage in Rats |
| title_full_unstemmed | Hydroethanolic Extracts of Ficus pumila Linn. Is Protective against Gentamicin-Induced Kidney Damage in Rats |
| title_short | Hydroethanolic Extracts of Ficus pumila Linn. Is Protective against Gentamicin-Induced Kidney Damage in Rats |
| title_sort | hydroethanolic extracts of ficus pumila linn is protective against gentamicin induced kidney damage in rats |
| url | https://ir.knust.edu.gh/handle/123456789/13114 |
| work_keys_str_mv | AT larbiechristopher hydroethanolicextractsofficuspumilalinnisprotectiveagainstgentamicininducedkidneydamageinrats AT siawportiaa hydroethanolicextractsofficuspumilalinnisprotectiveagainstgentamicininducedkidneydamageinrats AT zonsolomon hydroethanolicextractsofficuspumilalinnisprotectiveagainstgentamicininducedkidneydamageinrats AT appiahkubikwame hydroethanolicextractsofficuspumilalinnisprotectiveagainstgentamicininducedkidneydamageinrats |