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Stroke Among Young West Africans Evidence From the SIREN (Stroke Investigative Research and Educational Network) Large Multisite Case–Control Study
An article published in Stroke. 2018;49:1116-1122. DOI: 10.1161/STROKEAHA.118.020783
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| Language: | English |
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Stroke
2021
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| _version_ | 1867613133976109056 |
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| access_status_str | Open Access |
| author | Sarfo, Fred Stephen Ovbiagele, Bruce Gebregziabher, Mulugeta Wahab, Kolawole Akinyemi, Rufus Akpalu, Albert...et.al. |
| author_browse | Akinyemi, Rufus Akpalu, Albert...et.al. Gebregziabher, Mulugeta Ovbiagele, Bruce Sarfo, Fred Stephen Wahab, Kolawole |
| author_facet | Sarfo, Fred Stephen Ovbiagele, Bruce Gebregziabher, Mulugeta Wahab, Kolawole Akinyemi, Rufus Akpalu, Albert...et.al. |
| author_sort | Sarfo, Fred Stephen |
| collection | Thesis |
| description | An article published in Stroke. 2018;49:1116-1122. DOI: 10.1161/STROKEAHA.118.020783 |
| format | Article |
| id | oai:ir.knust.edu.gh:123456789/13443 |
| institution | KNUST (Ghana) |
| language | English |
| last_indexed | 2026-06-10T12:31:18.486Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from KNUSTSpace — Kwame Nkrumah University of Science & Technology (Ghana) |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Stroke |
| publisherStr | Stroke |
| record_format | dspace |
| source_str | KNUSTSpace — Kwame Nkrumah University of Science & Technology (Ghana) |
| spelling | oai:ir.knust.edu.gh:123456789/13443 Stroke Among Young West Africans Evidence From the SIREN (Stroke Investigative Research and Educational Network) Large Multisite Case–Control Study Sarfo, Fred Stephen Ovbiagele, Bruce Gebregziabher, Mulugeta Wahab, Kolawole Akinyemi, Rufus Akpalu, Albert...et.al. Diabetes mellitus Prevalence Public health Quality of life Stroke An article published in Stroke. 2018;49:1116-1122. DOI: 10.1161/STROKEAHA.118.020783 Background and Purpose—Stroke in lower and middle-income countries affects a young and productive age group. Data on factors associated with stroke in the young are sorely lacking from lower and middle-income countries. Our objective is to characterize the nature of stroke and its risk factors among young West Africans aged <50 years old. Methods—The SIREN (Stroke Investigative Research and Educational Network) is a multicenter, case–control study involving 15 sites in Nigeria and Ghana. Cases included adults aged ≥18 years with computed tomography/magnetic resonance imaging-confirmed stroke. Controls were age-and gender-matched stroke-free adults recruited from the communities in catchment areas of cases. Comprehensive evaluation for vascular, lifestyle, and psychosocial factors was performed. We used conditional logistic regression to estimate odds ratios and population attributable risks with 95% confidence intervals. Results—Five hundred fifteen (24.3%) out of 2118 cases enrolled were <50 years old. Among subjects <50 years old, hemorrhagic stroke proportion was 270 (52.5%) versus 245 (47.5%) for ischemic strokes. Etiologic subtypes of ischemic strokes included large artery atherosclerosis (40.0%), small vessel disease (28.6%), cardioembolism (11.0%), and undetermined (20.4%). Hypertension (91.7%), structural lesions (3.4%), and others (4.9%) were causally associated with hemorrhagic stroke. Six topmost modifiable factors associated with stroke in descending order of population attributable risk (95% confidence interval) were hypertension: 88.7% (82.5%–94.8%), dyslipidemia: 48.2% (30.6%–65.9%), diabetes mellitus: 22.6% (18.7%–26.5%), low green vegetable consumption: 18.2% (−6.8%–43.2%), stress: 14.5% (4.9%–24.1%), and cardiac disease: 8.4% (5.8%–11.1%). Conclusions—The high and rising burden of stroke among young Africans should be curtailed via aggressive, populationwide vascular risk factor control. KNUST 2021-02-24T10:55:18Z 2023-04-19T02:46:43Z 2021-02-24T10:55:18Z 2023-04-19T02:46:43Z 2018 Article Stroke. 2018;49:1116-1122. DOI: 10.1161/STROKEAHA.118.020783 https://ir.knust.edu.gh/handle/123456789/13443 en application/pdf Stroke |
| spellingShingle | Diabetes mellitus Prevalence Public health Quality of life Stroke Sarfo, Fred Stephen Ovbiagele, Bruce Gebregziabher, Mulugeta Wahab, Kolawole Akinyemi, Rufus Akpalu, Albert...et.al. Stroke Among Young West Africans Evidence From the SIREN (Stroke Investigative Research and Educational Network) Large Multisite Case–Control Study |
| title | Stroke Among Young West Africans Evidence From the SIREN (Stroke Investigative Research and Educational Network) Large Multisite Case–Control Study |
| title_full | Stroke Among Young West Africans Evidence From the SIREN (Stroke Investigative Research and Educational Network) Large Multisite Case–Control Study |
| title_fullStr | Stroke Among Young West Africans Evidence From the SIREN (Stroke Investigative Research and Educational Network) Large Multisite Case–Control Study |
| title_full_unstemmed | Stroke Among Young West Africans Evidence From the SIREN (Stroke Investigative Research and Educational Network) Large Multisite Case–Control Study |
| title_short | Stroke Among Young West Africans Evidence From the SIREN (Stroke Investigative Research and Educational Network) Large Multisite Case–Control Study |
| title_sort | stroke among young west africans evidence from the siren stroke investigative research and educational network large multisite case control study |
| topic | Diabetes mellitus Prevalence Public health Quality of life Stroke |
| url | https://ir.knust.edu.gh/handle/123456789/13443 |
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