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Organ damage in sickle cell disease study (ORDISS): protocol for a longitudinal cohort study based in Ghana
This article is published by BJM Open and is also available at http://bmjopen.bmj.com/
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| Format: | Article |
| Language: | English |
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BJM Open
2023
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| _version_ | 1867613134961770496 |
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| access_status_str | Open Access |
| author | Anie A Kofi Paintsil Vivian Ansong Daniel Owusu-Dabo Ellis Osei-Akoto Alex Ohene-Frempong Kwaku....et al |
| author_browse | Anie A Kofi Ansong Daniel Ohene-Frempong Kwaku....et al Osei-Akoto Alex Owusu-Dabo Ellis Paintsil Vivian |
| author_facet | Anie A Kofi Paintsil Vivian Ansong Daniel Owusu-Dabo Ellis Osei-Akoto Alex Ohene-Frempong Kwaku....et al |
| author_sort | Anie A Kofi |
| collection | Thesis |
| description | This article is published by BJM Open and is also available at http://bmjopen.bmj.com/ |
| format | Article |
| id | oai:ir.knust.edu.gh:123456789/14630 |
| institution | KNUST (Ghana) |
| language | English |
| last_indexed | 2026-06-10T12:31:19.760Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from KNUSTSpace — Kwame Nkrumah University of Science & Technology (Ghana) |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | BJM Open |
| publisherStr | BJM Open |
| record_format | dspace |
| source_str | KNUSTSpace — Kwame Nkrumah University of Science & Technology (Ghana) |
| spelling | oai:ir.knust.edu.gh:123456789/14630 Organ damage in sickle cell disease study (ORDISS): protocol for a longitudinal cohort study based in Ghana Anie A Kofi Paintsil Vivian Ansong Daniel Owusu-Dabo Ellis Osei-Akoto Alex Ohene-Frempong Kwaku....et al This article is published by BJM Open and is also available at http://bmjopen.bmj.com/ Introduction Sickle cell disease is highly prevalent in Africa with a significant public health burden. Nonetheless, morbidity and mortality in sickle cell disease that result from the progression of organ damage is not well understood. The Organ Damage in Sickle Cell Disease Study (ORDISS) is designed as a longitudinal cohort study to provide critical insight into cellular and molecular pathogenesis of chronic organ damage for the development of future innovative treatment. Methods and analysis ORDISS aims to recruit children aged 0–15 years who attend the Kumasi Centre for Sickle Cell Disease based at the Komfo Anokye Teaching Hospital in Kumasi, Ghana. Consent is obtained to collect blood and urine samples from the children during specified clinic visits and hospitalisations for acute events, to identify candidate and genetic markers of specific organ dysfunction and end-organ damage, over a 3 year period. In addition, data concerning clinical history and complications associated with sickle cell disease are collected. Samples are stored in biorepositories and analysed at the Kumasi Centre for Collaborative Research in Tropical Medicine, Ghana and the Centre for Translational and International Haematology, University of Pittsburgh, USA. Appropriate statistical analyses will be performed on the data acquired. Ethics and dissemination Research ethics approval was obtained at all participating sites. Results of the study will be submitted for publication in peer-reviewed journals, and the key findings presented at national and international conferences. KNUST 2023-12-06T08:59:33Z 2023-12-06T08:59:33Z 2017 Article Anie KA, Paintsil V, Owusu-Dabo E, et al. Organ damage in sickle cell disease study (ORDISS): protocol for a longitudinal cohort study based in Ghana 10.1136/ bmjopen-2017-016727 https://ir.knust.edu.gh/handle/123456789/14630 en application/pdf BJM Open |
| spellingShingle | Anie A Kofi Paintsil Vivian Ansong Daniel Owusu-Dabo Ellis Osei-Akoto Alex Ohene-Frempong Kwaku....et al Organ damage in sickle cell disease study (ORDISS): protocol for a longitudinal cohort study based in Ghana |
| title | Organ damage in sickle cell disease study (ORDISS): protocol for a longitudinal cohort study based in Ghana |
| title_full | Organ damage in sickle cell disease study (ORDISS): protocol for a longitudinal cohort study based in Ghana |
| title_fullStr | Organ damage in sickle cell disease study (ORDISS): protocol for a longitudinal cohort study based in Ghana |
| title_full_unstemmed | Organ damage in sickle cell disease study (ORDISS): protocol for a longitudinal cohort study based in Ghana |
| title_short | Organ damage in sickle cell disease study (ORDISS): protocol for a longitudinal cohort study based in Ghana |
| title_sort | organ damage in sickle cell disease study ordiss protocol for a longitudinal cohort study based in ghana |
| url | https://ir.knust.edu.gh/handle/123456789/14630 |
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