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High prevalence of antibiotic resistance in commensal Escherichia coli from healthy human sources in community settings
This article is published by Springer Nature and is also available at https://doi.org/10.1038/s41598-021-82693-4
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| Language: | English |
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Springer Nature
2023
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| _version_ | 1867613134969110528 |
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| access_status_str | Open Access |
| author | Nji Emmanuel Kazibwe Joseph Owusu-Dabo Ellis Hambridge Thomas Joko Alia Carolyn.....et al |
| author2 | 0000-0003-4232-4292 |
| author_browse | 0000-0003-4232-4292 Hambridge Thomas Joko Alia Carolyn.....et al Kazibwe Joseph Nji Emmanuel Owusu-Dabo Ellis |
| author_facet | 0000-0003-4232-4292 Nji Emmanuel Kazibwe Joseph Owusu-Dabo Ellis Hambridge Thomas Joko Alia Carolyn.....et al |
| author_sort | Nji Emmanuel |
| collection | Thesis |
| description | This article is published by Springer Nature and is also available at https://doi.org/10.1038/s41598-021-82693-4 |
| format | Article |
| id | oai:ir.knust.edu.gh:123456789/14832 |
| institution | KNUST (Ghana) |
| language | English |
| last_indexed | 2026-06-10T12:31:19.760Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from KNUSTSpace — Kwame Nkrumah University of Science & Technology (Ghana) |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | Springer Nature |
| publisherStr | Springer Nature |
| record_format | dspace |
| source_str | KNUSTSpace — Kwame Nkrumah University of Science & Technology (Ghana) |
| spelling | oai:ir.knust.edu.gh:123456789/14832 High prevalence of antibiotic resistance in commensal Escherichia coli from healthy human sources in community settings Nji Emmanuel Kazibwe Joseph Owusu-Dabo Ellis Hambridge Thomas Joko Alia Carolyn.....et al 0000-0003-4232-4292 This article is published by Springer Nature and is also available at https://doi.org/10.1038/s41598-021-82693-4 Antibiotic resistance is a global health crisis that requires urgent action to stop its spread. To counteract the spread of antibiotic resistance, we must improve our understanding of the origin and spread of resistant bacteria in both community and healthcare settings. Unfortunately, little attention is being given to contain the spread of antibiotic resistance in community settings (i.e., locations outside of a hospital inpatient, acute care setting, or a hospital clinic setting), despite some studies have consistently reported a high prevalence of antibiotic resistance in the community settings. This study aimed to investigate the prevalence of antibiotic resistance in commensal Escherichia coli isolates from healthy humans in community settings in LMICs. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we synthesized studies conducted from 1989 to May 2020. A total of 9363 articles were obtained from the search and prevalence data were extracted from 33 articles and pooled together. This gave a pooled prevalence of antibiotic resistance (top ten antibiotics commonly prescribed in LMICs) in commensal E. coli isolates from human sources in community settings in LMICs of: ampicillin (72% of 13,531 isolates, 95% CI: 65–79), cefotaxime (27% of 6700 isolates, 95% CI: 12–44), chloramphenicol (45% of 7012 isolates, 95% CI: 35–53), ciprofloxacin (17% of 10,618 isolates, 95% CI: 11–25), co-trimoxazole (63% of 10,561 isolates, 95% CI: 52–73), nalidixic acid (30% of 9819 isolates, 95% CI: 21–40), oxytetracycline (78% of 1451 isolates, 95% CI: 65–88), streptomycin (58% of 3831 isolates, 95% CI: 44–72), tetracycline (67% of 11,847 isolates, 95% CI: 59–74), and trimethoprim (67% of 3265 isolates, 95% CI: 59–75). Here, we provided an appraisal of the evidence of the high prevalence of antibiotic resistance by commensal E. coli in community settings in LMICs. Our findings will have important ramifications for public health policy design to contain the spread of antibiotic resistance in community settings. Indeed, commensal E. coli is the main reservoir for spreading antibiotic resistance to other pathogenic enteric bacteria via mobile genetic elements. KNUST 2023-12-13T14:44:50Z 2023-12-13T14:44:50Z 2021 Article Krumkamp, R., Struck, N.S., Lorenz, E. et al. Classification of invasive bloodstream infections and Plasmodium falciparum malaria using autoantibodies as biomarkers. Sci Rep 10, 21168 (2020). https://doi.org/10.1038/s41598-020-78155-y 10.1038/s41598-021-82693-4 https://ir.knust.edu.gh/handle/123456789/14832 en application/pdf Springer Nature |
| spellingShingle | Nji Emmanuel Kazibwe Joseph Owusu-Dabo Ellis Hambridge Thomas Joko Alia Carolyn.....et al High prevalence of antibiotic resistance in commensal Escherichia coli from healthy human sources in community settings |
| title | High prevalence of antibiotic resistance in commensal Escherichia coli from healthy human sources in community settings |
| title_full | High prevalence of antibiotic resistance in commensal Escherichia coli from healthy human sources in community settings |
| title_fullStr | High prevalence of antibiotic resistance in commensal Escherichia coli from healthy human sources in community settings |
| title_full_unstemmed | High prevalence of antibiotic resistance in commensal Escherichia coli from healthy human sources in community settings |
| title_short | High prevalence of antibiotic resistance in commensal Escherichia coli from healthy human sources in community settings |
| title_sort | high prevalence of antibiotic resistance in commensal escherichia coli from healthy human sources in community settings |
| url | https://ir.knust.edu.gh/handle/123456789/14832 |
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