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Human defensins and Th-1 cytokines in hepatitis C viral infection
This is an article published by Dorcas Ohui Owusu et al. Human defensins and Th-1 cytokines in hepatitis C viral infection. Pan African Medical Journal. 2020;37(103). 10.11604/pamj.2020.37.103.25211 Available online at: https://www.panafrican-med-journal.com//content/article/37/103/full
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| Format: | Article |
| Language: | English |
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Pan African Medical Journal
2024
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| _version_ | 1867613135036219392 |
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| access_status_str | Open Access |
| author | Owusu, Dorcas Ohui Owusu, Michael Owusu, Bright Afriyie |
| author2 | 0000-0003-4299-5870 |
| author_browse | 0000-0003-4299-5870 Owusu, Bright Afriyie Owusu, Dorcas Ohui Owusu, Michael |
| author_facet | 0000-0003-4299-5870 Owusu, Dorcas Ohui Owusu, Michael Owusu, Bright Afriyie |
| author_sort | Owusu, Dorcas Ohui |
| collection | Thesis |
| description | This is an article published by Dorcas Ohui Owusu et al. Human defensins and Th-1 cytokines in hepatitis C viral infection. Pan African Medical Journal. 2020;37(103). 10.11604/pamj.2020.37.103.25211
Available online at: https://www.panafrican-med-journal.com//content/article/37/103/full |
| format | Article |
| id | oai:ir.knust.edu.gh:123456789/15524 |
| institution | KNUST (Ghana) |
| language | English |
| last_indexed | 2026-06-10T12:31:19.760Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from KNUSTSpace — Kwame Nkrumah University of Science & Technology (Ghana) |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | Pan African Medical Journal |
| publisherStr | Pan African Medical Journal |
| record_format | dspace |
| source_str | KNUSTSpace — Kwame Nkrumah University of Science & Technology (Ghana) |
| spelling | oai:ir.knust.edu.gh:123456789/15524 Human defensins and Th-1 cytokines in hepatitis C viral infection Owusu, Dorcas Ohui Owusu, Michael Owusu, Bright Afriyie 0000-0003-4299-5870 0000-0001-5066-150X This is an article published by Dorcas Ohui Owusu et al. Human defensins and Th-1 cytokines in hepatitis C viral infection. Pan African Medical Journal. 2020;37(103). 10.11604/pamj.2020.37.103.25211 Available online at: https://www.panafrican-med-journal.com//content/article/37/103/full Introduction: active or chronic exacerbated forms of hepatitis C virus (HCV) infection subsequently progress to liver disease and human defensins has been determined to have some level of anti-viral properties invitro whilst the expression of T helper-1 cytokines is known to promote complete recovery from acute HCV infection. The study sought to determine relationship between these immune responses. Methods: a cross sectional descriptive study design was employed. Hundred and thirty-two individuals were assessed were assessed for to anti-HCV, HCV RNA, serum levels of human alpha defensins 1 (HAD-1) and human beta defensins 1 (HBD-1). T helper 1 cytokines (IL-2, IFN gamma, TNF alpha) secreted in serum were also analyzed using commercial ELISA assay. The study was conducted in Kumasi, Obuasi and Daboya in Ghana. Results: the serum mean concentrations of HAD-1, HBD-1, IL-2, IFN gamma and TNF alpha showed no significant difference in concentrations among participants with chronic, spontaneously recovered or negative to HCV infection (p>0.05). Persons with hepatitis B co-infection were more likely to develop chronic HCV infection (p=0.039). HAD-1 and HBD-1 showed significant positive association with IL-2 (p=0.000) whilst only HAD-1 positively correlated with IL-2 (p<0.000). Conclusion: the immunological markers determined had no association with the status of HCV infection. HAD-1 increased with increasing levels of IL-2. These findings suggest that during HCV infection, inflammatory response through the production of cytokines by IL-2 cells may affect the release of HAD-1 and HBD-1. KNUST 2024-02-21T12:21:45Z 2024-02-21T12:21:45Z 2020 Article Dorcas Ohui Owusu et al. Human defensins and Th-1 cytokines in hepatitis C viral infection. Pan African Medical Journal. 2020;37(103). 10.11604/pamj.2020.37.103.25211 Available online at: https://www.panafrican-med-journal.com//content/article/37/103/full https://www.panafrican-med-journal.com//content/article/37/103/full https://ir.knust.edu.gh/handle/123456789/15524 en application/pdf Pan African Medical Journal |
| spellingShingle | Owusu, Dorcas Ohui Owusu, Michael Owusu, Bright Afriyie Human defensins and Th-1 cytokines in hepatitis C viral infection |
| title | Human defensins and Th-1 cytokines in hepatitis C viral infection |
| title_full | Human defensins and Th-1 cytokines in hepatitis C viral infection |
| title_fullStr | Human defensins and Th-1 cytokines in hepatitis C viral infection |
| title_full_unstemmed | Human defensins and Th-1 cytokines in hepatitis C viral infection |
| title_short | Human defensins and Th-1 cytokines in hepatitis C viral infection |
| title_sort | human defensins and th 1 cytokines in hepatitis c viral infection |
| url | https://www.panafrican-med-journal.com//content/article/37/103/full https://ir.knust.edu.gh/handle/123456789/15524 |
| work_keys_str_mv | AT owusudorcasohui humandefensinsandth1cytokinesinhepatitiscviralinfection AT owusumichael humandefensinsandth1cytokinesinhepatitiscviralinfection AT owusubrightafriyie humandefensinsandth1cytokinesinhepatitiscviralinfection |