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Association of genetic variants with prostate cancer in Africa: a concise review
This article is published by Springer Open and is always available at https://doi.org/10.1186/s43042-021-00157-w
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Springer Open
2024
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| _version_ | 1867613138386419712 |
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| access_status_str | Open Access |
| author | Acheampong, Emmanuel Asamoah Adu, Evans Obirikorang, Christian Amoah, George Afriyie, Osei Owusu Yorke, Joseph Odame Anto, Enoch Adu Gyamfi, Michael |
| author2 | 0000-0002-5229-0340 |
| author_browse | 0000-0002-5229-0340 Acheampong, Emmanuel Adu Gyamfi, Michael Afriyie, Osei Owusu Amoah, George Asamoah Adu, Evans Obirikorang, Christian Odame Anto, Enoch Yorke, Joseph |
| author_facet | 0000-0002-5229-0340 Acheampong, Emmanuel Asamoah Adu, Evans Obirikorang, Christian Amoah, George Afriyie, Osei Owusu Yorke, Joseph Odame Anto, Enoch Adu Gyamfi, Michael |
| author_sort | Acheampong, Emmanuel |
| collection | Thesis |
| description | This article is published by Springer Open and is always available at https://doi.org/10.1186/s43042-021-00157-w |
| format | Article |
| id | oai:ir.knust.edu.gh:123456789/15742 |
| institution | KNUST (Ghana) |
| language | English |
| last_indexed | 2026-06-10T12:31:22.621Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from KNUSTSpace — Kwame Nkrumah University of Science & Technology (Ghana) |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | Springer Open |
| publisherStr | Springer Open |
| record_format | dspace |
| source_str | KNUSTSpace — Kwame Nkrumah University of Science & Technology (Ghana) |
| spelling | oai:ir.knust.edu.gh:123456789/15742 Association of genetic variants with prostate cancer in Africa: a concise review Acheampong, Emmanuel Asamoah Adu, Evans Obirikorang, Christian Amoah, George Afriyie, Osei Owusu Yorke, Joseph Odame Anto, Enoch Adu Gyamfi, Michael 0000-0002-5229-0340 This article is published by Springer Open and is always available at https://doi.org/10.1186/s43042-021-00157-w Background: Prostate cancer (PCa) has one of the highest heritability of all major cancers, where the genetic contribution has been documented, and knowledge about the molecular genetics of the disease is increasing. However, the extent and aspects to which genetic variants explain PCa heritability in Africa are limited. Main body: In this review, we summarize studies that highlight how identified genetic variants explain differences in PCa incidence and presentation across ethnic groups. We also present the knowledge gaps in PCa genetics in Africa and why Africa represents an untapped potential ground for genetic studies on PCa. A significant number of genome-wide association studies, linkage, and fine-mapping analyses have been conducted globally, and that explains 30–33% of PCa heritability. The African ancestry has a significant mention in PCa incidence and presentation. To date, the candidate gene approach has replicated 23 polymorphisms including dinucleotide and trinucleotide repeats in 16 genes. CYP17-rs743572, CYP3A4-rs2740574, CYP3A5-rs776746, CYP3A43-rs501275, and haplotype blocks, containing these variants, are significantly associated with PCa among some population groups but not others. With the few existing studies, the extent of genetic diversity in Africa suggests that genetic associations of PCa to African ancestry go beyond nucleotide sequence polymorphisms, to a level of environmental adaptation, which may interpret genetic risk profiles. Also, the shreds of evidence suggest that evolutionary history contributes to the high rates of PCa relative to African ancestry, and genetic associations do not always replicate across populations. Conclusion: The genetic architecture of PCa in Africa provides important contributions to the global understanding of PCa specifically the African-ancestry hypothesis. There is a need for more prostate cancer consortiums to justify the heritable certainties of PCa among Africans, and emphasis should be placed on the genetic epidemiological model of PCa in Africa. KNUST 2024-05-29T16:34:22Z 2024-05-29T16:34:22Z 2021 Article Egyptian Journal of Medical Human Genetics 10.1186/s43042-021-00157-w https://ir.knust.edu.gh/handle/123456789/15742 en application/pdf Springer Open |
| spellingShingle | Acheampong, Emmanuel Asamoah Adu, Evans Obirikorang, Christian Amoah, George Afriyie, Osei Owusu Yorke, Joseph Odame Anto, Enoch Adu Gyamfi, Michael Association of genetic variants with prostate cancer in Africa: a concise review |
| title | Association of genetic variants with prostate cancer in Africa: a concise review |
| title_full | Association of genetic variants with prostate cancer in Africa: a concise review |
| title_fullStr | Association of genetic variants with prostate cancer in Africa: a concise review |
| title_full_unstemmed | Association of genetic variants with prostate cancer in Africa: a concise review |
| title_short | Association of genetic variants with prostate cancer in Africa: a concise review |
| title_sort | association of genetic variants with prostate cancer in africa a concise review |
| url | https://ir.knust.edu.gh/handle/123456789/15742 |
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