Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
Mechanistic Studies and Mathematical Models for Mycolactone Toxin and Autoinhibitory WASP: Model Mechanisms for Buruli ulcer Initiation and Spread.
A dissertation submitted to the Department of Mathematics, Kwame Nkrumah University of science and technology in partial fulfillment of the requirement for the degree of Doctor of Philosophy in Applied Mathematics, 2015
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis |
| Language: | English |
| Published: |
2016
|
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867613138498617344 |
|---|---|
| access_status_str | Open Access |
| author | Nyarko, Peter Romeo |
| author_browse | Nyarko, Peter Romeo |
| author_facet | Nyarko, Peter Romeo |
| author_sort | Nyarko, Peter Romeo |
| collection | Thesis |
| description | A dissertation submitted to the Department of Mathematics, Kwame Nkrumah University of science and technology in partial fulfillment of the requirement for the degree of Doctor of Philosophy in Applied Mathematics, 2015 |
| format | Thesis |
| id | oai:ir.knust.edu.gh:123456789/8127 |
| institution | KNUST (Ghana) |
| language | English |
| last_indexed | 2026-06-10T12:31:22.621Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from KNUSTSpace — Kwame Nkrumah University of Science & Technology (Ghana) |
| publishDate | 2016 |
| publishDateRange | 2016 |
| publishDateSort | 2016 |
| record_format | dspace |
| source_str | KNUSTSpace — Kwame Nkrumah University of Science & Technology (Ghana) |
| spelling | oai:ir.knust.edu.gh:123456789/8127 Mechanistic Studies and Mathematical Models for Mycolactone Toxin and Autoinhibitory WASP: Model Mechanisms for Buruli ulcer Initiation and Spread. Nyarko, Peter Romeo A dissertation submitted to the Department of Mathematics, Kwame Nkrumah University of science and technology in partial fulfillment of the requirement for the degree of Doctor of Philosophy in Applied Mathematics, 2015 The Wiskott-Aldrich Syndrome Protein (WASP) has been implicated in many diseases such as Wiskott-Aldrich Syndrome (WAS) and Buruli ulcer. Mycobactrium ulcerans is the main causative organism of Buruli ulcer (BU) disease. The bacteria secretes a polyketide lipid toxin (Mycolactone). The toxin not only di uses through the cell membranes, but also binds, hijacks and disrupts the normal functions of WASP in the cytoplasm leading to over polymerization of actin lament, cytoskeletal rearrangement and eventually cell death through necrosis. In pre-ulcerative BU disease, toxins extend beyond the actual size of the lesion. A mathematical model is developed to describe the binding mechanism of the two conformations of WASP and the complexes formed using the idea of isomerization. The formulation utilizes ligand concentration-dependence (ligand-receptor), equilibrium and conservation principles. By this approach, we are able to determine the fractional response of WASP against change in concentration of its activators; KNUST 2016-02-09T15:40:23Z 2023-04-19T21:11:14Z 2016-02-09T15:40:23Z 2023-04-19T21:11:14Z 2015-11-09 Thesis https://ir.knust.edu.gh/handle/123456789/8127 en application/pdf |
| spellingShingle | Nyarko, Peter Romeo Mechanistic Studies and Mathematical Models for Mycolactone Toxin and Autoinhibitory WASP: Model Mechanisms for Buruli ulcer Initiation and Spread. |
| title | Mechanistic Studies and Mathematical Models for Mycolactone Toxin and Autoinhibitory WASP: Model Mechanisms for Buruli ulcer Initiation and Spread. |
| title_full | Mechanistic Studies and Mathematical Models for Mycolactone Toxin and Autoinhibitory WASP: Model Mechanisms for Buruli ulcer Initiation and Spread. |
| title_fullStr | Mechanistic Studies and Mathematical Models for Mycolactone Toxin and Autoinhibitory WASP: Model Mechanisms for Buruli ulcer Initiation and Spread. |
| title_full_unstemmed | Mechanistic Studies and Mathematical Models for Mycolactone Toxin and Autoinhibitory WASP: Model Mechanisms for Buruli ulcer Initiation and Spread. |
| title_short | Mechanistic Studies and Mathematical Models for Mycolactone Toxin and Autoinhibitory WASP: Model Mechanisms for Buruli ulcer Initiation and Spread. |
| title_sort | mechanistic studies and mathematical models for mycolactone toxin and autoinhibitory wasp model mechanisms for buruli ulcer initiation and spread |
| url | https://ir.knust.edu.gh/handle/123456789/8127 |
| work_keys_str_mv | AT nyarkopeterromeo mechanisticstudiesandmathematicalmodelsformycolactonetoxinandautoinhibitorywaspmodelmechanismsforburuliulcerinitiationandspread |