Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
Novel acyclic nucleotide phosphonates against RNA viruses
Includes bibliographical references.
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Chemistry
2014
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867613205457534976 |
|---|---|
| access_status_str | Open Access |
| author | Bowden, Gregory David |
| author2 | Hunter, Roger |
| author_browse | Bowden, Gregory David Hunter, Roger |
| author_facet | Hunter, Roger Bowden, Gregory David |
| author_sort | Bowden, Gregory David |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/10258 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:26.116Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/10258 Novel acyclic nucleotide phosphonates against RNA viruses Bowden, Gregory David Hunter, Roger Chemistry Includes bibliographical references. Acyclic nucleotide phosphonates (ANPs) have been used for years as successful anti-viral agents against diseases such as HIV/AIDS and hepatitis while the drug ribavirin is one of the only drugs available for the treatment of RNA-viral infections which mainly affect the developing world. The large and unmet need for anti-RNA viral treatments has prompted this study into the design and synthesis of a range of ANPs, which includes a series of ribavirin-based ANP derivatives. The series of compounds was synthesised from a diisopropyl protected phosphonomethoxyethyl (PME) synthon and included an arylethynyltriazole derivative which was produced via a Sonogashira palladium catalysed cross-coupling reaction. A selection of these compounds was then deprotected to their corresponding phosphonic acids via a bromotrimethylsilane mediated phosphonate ester hydrolysis. In one example, a bis(pivaloyloxymethyl) prodrug variant was produced in order to probe a general synthesis for prodrug protected ANP derivatives. All new compounds were characterised by NMR, IR, and Mass spectroscopic techniques. 2014-12-27T14:16:33Z 2014-12-27T14:16:33Z 2012 Master Thesis Masters MSc http://hdl.handle.net/11427/10258 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Chemistry Bowden, Gregory David Novel acyclic nucleotide phosphonates against RNA viruses |
| thesis_degree_str | Master's |
| title | Novel acyclic nucleotide phosphonates against RNA viruses |
| title_full | Novel acyclic nucleotide phosphonates against RNA viruses |
| title_fullStr | Novel acyclic nucleotide phosphonates against RNA viruses |
| title_full_unstemmed | Novel acyclic nucleotide phosphonates against RNA viruses |
| title_short | Novel acyclic nucleotide phosphonates against RNA viruses |
| title_sort | novel acyclic nucleotide phosphonates against rna viruses |
| topic | Chemistry |
| url | http://hdl.handle.net/11427/10258 |
| work_keys_str_mv | AT bowdengregorydavid novelacyclicnucleotidephosphonatesagainstrnaviruses |