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The effect of birth weight and gestational age on BCG-induced immune responses in infants following BCG vaccination
Includes bibliographical references (leaves 102-114).
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Paediatrics and Child Health
2014
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| _version_ | 1867613480056520704 |
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| access_status_str | Open Access |
| author | Dube, Frederick |
| author2 | Hanekom, Willem A |
| author_browse | Dube, Frederick Hanekom, Willem A |
| author_facet | Hanekom, Willem A Dube, Frederick |
| author_sort | Dube, Frederick |
| collection | Thesis |
| description | Includes bibliographical references (leaves 102-114). |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/10377 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:36:48.904Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Paediatrics and Child Health |
| publisherStr | Department of Paediatrics and Child Health |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/10377 The effect of birth weight and gestational age on BCG-induced immune responses in infants following BCG vaccination Dube, Frederick Hanekom, Willem A Medicine Includes bibliographical references (leaves 102-114). Bacillus Calmette?Gu?rin (BCG), the only currently licensed tuberculosis (TB) vaccine, provides variable efficacy. Despite the use of BCG, TB remains a global health problem. BCG is administered at birth; however, more than 15% of infants are born preterm [PT (<37 weeks gestation)], or have low birth weights [LBW (<2,500g)], with >90% of these born in developing countries, where the majority of TB cases are found. It is not known how birth weight at the time of vaccination may affect the BCG-induced immune response and subsequent protection against TB. We hypothesised that BCG-vaccinated PT and LBW infants would have a qualitatively and quantitatevely less optimal immune response, compared to term or normal birth weight (NBW) infants. 2014-12-28T14:55:44Z 2014-12-28T14:55:44Z 2010 Master Thesis Masters MSc http://hdl.handle.net/11427/10377 eng application/pdf Department of Paediatrics and Child Health Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medicine Dube, Frederick The effect of birth weight and gestational age on BCG-induced immune responses in infants following BCG vaccination |
| thesis_degree_str | Master's |
| title | The effect of birth weight and gestational age on BCG-induced immune responses in infants following BCG vaccination |
| title_full | The effect of birth weight and gestational age on BCG-induced immune responses in infants following BCG vaccination |
| title_fullStr | The effect of birth weight and gestational age on BCG-induced immune responses in infants following BCG vaccination |
| title_full_unstemmed | The effect of birth weight and gestational age on BCG-induced immune responses in infants following BCG vaccination |
| title_short | The effect of birth weight and gestational age on BCG-induced immune responses in infants following BCG vaccination |
| title_sort | effect of birth weight and gestational age on bcg induced immune responses in infants following bcg vaccination |
| topic | Medicine |
| url | http://hdl.handle.net/11427/10377 |
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