Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
Investigation of the genetic basis of antibiotic resistance in Mycobacterium tuberculosis
The emergence of antibiotic resistant strains of Mycobacterium tuberculosis, coupled with the time it takes to perform phenotypic drug susceptibility testing of this organism, makes the treatment of tuberculosis increasingly difficult. Several genotypic assays for the rapid detection of drug resista...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Division of Medical Microbiology
2014
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867613987958423552 |
|---|---|
| access_status_str | Open Access |
| author | Evans, Joanna |
| author2 | Segal, Heidi |
| author_browse | Evans, Joanna Segal, Heidi |
| author_facet | Segal, Heidi Evans, Joanna |
| author_sort | Evans, Joanna |
| collection | Thesis |
| description | The emergence of antibiotic resistant strains of Mycobacterium tuberculosis, coupled with the time it takes to perform phenotypic drug susceptibility testing of this organism, makes the treatment of tuberculosis increasingly difficult. Several genotypic assays for the rapid detection of drug resistance in M. tuberculosis have been developed, but the sensitivity with which these assays identify resistance differs geographically. Additionally, the identification of phenotypically resistant isolates with no identifiable genotypic marker suggests that other factors, such as differential gene expression, may play a role in the development of drug resistance in M. tuberculosis. This investigation aims to both develop and evaluate rapid genotypic assays for the detection of resistance to both first- and second-line drugs in M. tuberculosis, and to investigate the role of alternative sigma factors in the progression to multidrug resistant M. tuberculosis. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/10434 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:44:53.277Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Division of Medical Microbiology |
| publisherStr | Division of Medical Microbiology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/10434 Investigation of the genetic basis of antibiotic resistance in Mycobacterium tuberculosis Evans, Joanna Segal, Heidi Medical Microbiology The emergence of antibiotic resistant strains of Mycobacterium tuberculosis, coupled with the time it takes to perform phenotypic drug susceptibility testing of this organism, makes the treatment of tuberculosis increasingly difficult. Several genotypic assays for the rapid detection of drug resistance in M. tuberculosis have been developed, but the sensitivity with which these assays identify resistance differs geographically. Additionally, the identification of phenotypically resistant isolates with no identifiable genotypic marker suggests that other factors, such as differential gene expression, may play a role in the development of drug resistance in M. tuberculosis. This investigation aims to both develop and evaluate rapid genotypic assays for the detection of resistance to both first- and second-line drugs in M. tuberculosis, and to investigate the role of alternative sigma factors in the progression to multidrug resistant M. tuberculosis. 2014-12-28T20:05:42Z 2014-12-28T20:05:42Z 2010 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/10434 eng application/pdf Division of Medical Microbiology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medical Microbiology Evans, Joanna Investigation of the genetic basis of antibiotic resistance in Mycobacterium tuberculosis |
| thesis_degree_str | Doctoral |
| title | Investigation of the genetic basis of antibiotic resistance in Mycobacterium tuberculosis |
| title_full | Investigation of the genetic basis of antibiotic resistance in Mycobacterium tuberculosis |
| title_fullStr | Investigation of the genetic basis of antibiotic resistance in Mycobacterium tuberculosis |
| title_full_unstemmed | Investigation of the genetic basis of antibiotic resistance in Mycobacterium tuberculosis |
| title_short | Investigation of the genetic basis of antibiotic resistance in Mycobacterium tuberculosis |
| title_sort | investigation of the genetic basis of antibiotic resistance in mycobacterium tuberculosis |
| topic | Medical Microbiology |
| url | http://hdl.handle.net/11427/10434 |
| work_keys_str_mv | AT evansjoanna investigationofthegeneticbasisofantibioticresistanceinmycobacteriumtuberculosis |