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Bacteriodes fragilis interactions with the collagen type I component of the host extracellular matrix
Includes bibliographical references (p. 116-126).
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Molecular and Cell Biology
2014
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| _version_ | 1867613248262504448 |
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| access_status_str | Open Access |
| author | Galvao, Bruna Patricia Gomes de Vasconcelos |
| author2 | Abratt, Valerie Rose |
| author_browse | Abratt, Valerie Rose Galvao, Bruna Patricia Gomes de Vasconcelos |
| author_facet | Abratt, Valerie Rose Galvao, Bruna Patricia Gomes de Vasconcelos |
| author_sort | Galvao, Bruna Patricia Gomes de Vasconcelos |
| collection | Thesis |
| description | Includes bibliographical references (p. 116-126). |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/10522 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:07.122Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Molecular and Cell Biology |
| publisherStr | Department of Molecular and Cell Biology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/10522 Bacteriodes fragilis interactions with the collagen type I component of the host extracellular matrix Galvao, Bruna Patricia Gomes de Vasconcelos Abratt, Valerie Rose Includes bibliographical references (p. 116-126). Bacteroides fragilis is an opportunistic pathogen which can cause life threatening infections in humans and animals. The increasing incidence of antibiotic resistance by the bacterium has prompted the search for novel therapeutic targets. The idea of antivirulence over antimicrobial drug development is becoming increasingly popular and invites detailed research into the virulence factors of target pathogens. The ability to adhere to, and degrade components of the extracellular matrix, such as collagen, is critical in bacterial colonisation and host cell invasion. The aim of this dissertation was to specifically identify the collagen type I adhesins and proteases in the common research strain, B. fragilis 638R, as well as in 23 clinical isolates from Groote Schuur Hospital (GSH), Cape Town. 2014-12-30T06:42:29Z 2014-12-30T06:42:29Z 2010 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/10522 eng application/pdf Department of Molecular and Cell Biology Faculty of Science University of Cape Town |
| spellingShingle | Galvao, Bruna Patricia Gomes de Vasconcelos Bacteriodes fragilis interactions with the collagen type I component of the host extracellular matrix |
| thesis_degree_str | Doctoral |
| title | Bacteriodes fragilis interactions with the collagen type I component of the host extracellular matrix |
| title_full | Bacteriodes fragilis interactions with the collagen type I component of the host extracellular matrix |
| title_fullStr | Bacteriodes fragilis interactions with the collagen type I component of the host extracellular matrix |
| title_full_unstemmed | Bacteriodes fragilis interactions with the collagen type I component of the host extracellular matrix |
| title_short | Bacteriodes fragilis interactions with the collagen type I component of the host extracellular matrix |
| title_sort | bacteriodes fragilis interactions with the collagen type i component of the host extracellular matrix |
| url | http://hdl.handle.net/11427/10522 |
| work_keys_str_mv | AT galvaobrunapatriciagomesdevasconcelos bacteriodesfragilisinteractionswiththecollagentypeicomponentofthehostextracellularmatrix |