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Incidence of aminoglycoside-induced hearing loss in HIV positive and HIV negative multidrug-resistant tuberculosis patients
Aims of the study: To document the incidence and severity of aminoglycoside-induced ototoxicity at Brooklyn Chest Hospital; To determine the prevalence of the 6 known aminoglycoside-induced deafness mutations in the MT-RNR1 gene (A1555G, C1494T, T1095C, T1291C, A827G and 961 indel C) in a cohort of...
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| Format: | Thesis |
| Language: | English |
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Division of Otorhinolaryngology
2014
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| _version_ | 1867613164174049281 |
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| access_status_str | Open Access |
| author | Harris, Tashneem |
| author_browse | Harris, Tashneem |
| author_facet | Harris, Tashneem |
| author_sort | Harris, Tashneem |
| collection | Thesis |
| description | Aims of the study: To document the incidence and severity of aminoglycoside-induced ototoxicity at Brooklyn Chest Hospital; To determine the prevalence of the 6 known aminoglycoside-induced deafness mutations in the MT-RNR1 gene (A1555G, C1494T, T1095C, T1291C, A827G and 961 indel C) in a cohort of MDR-TB patients; To determine whether HIV positive MDR-TB patients are more likely to develop aminoglycoside-induced hearing loss than HIV negative MDR-TB patients; To provide clinical guidelines to the medical fraternity on the use of aminoglycoside antibiotics with regard to the side-effect of ototoxicity. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/10587 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:31:47.142Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Division of Otorhinolaryngology |
| publisherStr | Division of Otorhinolaryngology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/10587 Incidence of aminoglycoside-induced hearing loss in HIV positive and HIV negative multidrug-resistant tuberculosis patients Harris, Tashneem Otorhinolaryngology Aims of the study: To document the incidence and severity of aminoglycoside-induced ototoxicity at Brooklyn Chest Hospital; To determine the prevalence of the 6 known aminoglycoside-induced deafness mutations in the MT-RNR1 gene (A1555G, C1494T, T1095C, T1291C, A827G and 961 indel C) in a cohort of MDR-TB patients; To determine whether HIV positive MDR-TB patients are more likely to develop aminoglycoside-induced hearing loss than HIV negative MDR-TB patients; To provide clinical guidelines to the medical fraternity on the use of aminoglycoside antibiotics with regard to the side-effect of ototoxicity. 2014-12-30T19:40:20Z 2014-12-30T19:40:20Z 2011 Master Thesis Masters MMed http://hdl.handle.net/11427/10587 eng application/pdf Division of Otorhinolaryngology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Otorhinolaryngology Harris, Tashneem Incidence of aminoglycoside-induced hearing loss in HIV positive and HIV negative multidrug-resistant tuberculosis patients |
| thesis_degree_str | Master's |
| title | Incidence of aminoglycoside-induced hearing loss in HIV positive and HIV negative multidrug-resistant tuberculosis patients |
| title_full | Incidence of aminoglycoside-induced hearing loss in HIV positive and HIV negative multidrug-resistant tuberculosis patients |
| title_fullStr | Incidence of aminoglycoside-induced hearing loss in HIV positive and HIV negative multidrug-resistant tuberculosis patients |
| title_full_unstemmed | Incidence of aminoglycoside-induced hearing loss in HIV positive and HIV negative multidrug-resistant tuberculosis patients |
| title_short | Incidence of aminoglycoside-induced hearing loss in HIV positive and HIV negative multidrug-resistant tuberculosis patients |
| title_sort | incidence of aminoglycoside induced hearing loss in hiv positive and hiv negative multidrug resistant tuberculosis patients |
| topic | Otorhinolaryngology |
| url | http://hdl.handle.net/11427/10587 |
| work_keys_str_mv | AT harristashneem incidenceofaminoglycosideinducedhearinglossinhivpositiveandhivnegativemultidrugresistanttuberculosispatients |