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An investigation into the role of acetylation and ligand-dependent nuclear localisation in glucocorticoid receptor transcriptional regulation
Includes bibliographical references (leaves 134-151).
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Molecular and Cell Biology
2014
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| _version_ | 1867613267185106944 |
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| access_status_str | Open Access |
| author | Hadley, Katie Emma |
| author2 | Hapgood, Janet |
| author_browse | Hadley, Katie Emma Hapgood, Janet |
| author_facet | Hapgood, Janet Hadley, Katie Emma |
| author_sort | Hadley, Katie Emma |
| collection | Thesis |
| description | Includes bibliographical references (leaves 134-151). |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/10607 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:25.185Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Molecular and Cell Biology |
| publisherStr | Department of Molecular and Cell Biology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/10607 An investigation into the role of acetylation and ligand-dependent nuclear localisation in glucocorticoid receptor transcriptional regulation Hadley, Katie Emma Hapgood, Janet Cell Biology Includes bibliographical references (leaves 134-151). The glucocorticoid receptor (GR) is a ligand-activated transcription factor which, due to its central role in anti-inflammatory responses, is a target of many therapeutically prescribed drugs. The GR undergoes multiple post-translational modifications, including phosphorylation and acetylation; however the role of GR acetylation in transactivation is unclear. 2014-12-30T19:45:00Z 2014-12-30T19:45:00Z 2010 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/10607 eng application/pdf Department of Molecular and Cell Biology Faculty of Science University of Cape Town |
| spellingShingle | Cell Biology Hadley, Katie Emma An investigation into the role of acetylation and ligand-dependent nuclear localisation in glucocorticoid receptor transcriptional regulation |
| thesis_degree_str | Doctoral |
| title | An investigation into the role of acetylation and ligand-dependent nuclear localisation in glucocorticoid receptor transcriptional regulation |
| title_full | An investigation into the role of acetylation and ligand-dependent nuclear localisation in glucocorticoid receptor transcriptional regulation |
| title_fullStr | An investigation into the role of acetylation and ligand-dependent nuclear localisation in glucocorticoid receptor transcriptional regulation |
| title_full_unstemmed | An investigation into the role of acetylation and ligand-dependent nuclear localisation in glucocorticoid receptor transcriptional regulation |
| title_short | An investigation into the role of acetylation and ligand-dependent nuclear localisation in glucocorticoid receptor transcriptional regulation |
| title_sort | investigation into the role of acetylation and ligand dependent nuclear localisation in glucocorticoid receptor transcriptional regulation |
| topic | Cell Biology |
| url | http://hdl.handle.net/11427/10607 |
| work_keys_str_mv | AT hadleykatieemma aninvestigationintotheroleofacetylationandliganddependentnuclearlocalisationinglucocorticoidreceptortranscriptionalregulation AT hadleykatieemma investigationintotheroleofacetylationandliganddependentnuclearlocalisationinglucocorticoidreceptortranscriptionalregulation |